Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/KCNQ1OT1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/KCNQ1OT1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/KCNQ1OT1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KCNQ1OT1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KCNQ1OT1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/KCNQ1OT1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/KCNQ1OT1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/KCNQ1OT1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KCNQ1OT1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00313318 | Lung | IAC | positive regulation of cellular catabolic process | 98/2061 | 427/18723 | 7.79e-13 | 9.25e-10 | 98 |
GO:00609646 | Lung | IAC | regulation of gene silencing by miRNA | 18/2061 | 49/18723 | 2.10e-06 | 9.45e-05 | 18 |
GO:00601475 | Lung | IAC | regulation of posttranscriptional gene silencing | 18/2061 | 52/18723 | 5.60e-06 | 2.13e-04 | 18 |
GO:00609664 | Lung | IAC | regulation of gene silencing by RNA | 18/2061 | 53/18723 | 7.61e-06 | 2.64e-04 | 18 |
GO:00105864 | Lung | IAC | miRNA metabolic process | 12/2061 | 27/18723 | 1.09e-05 | 3.39e-04 | 12 |
GO:00064017 | Lung | IAC | RNA catabolic process | 54/2061 | 278/18723 | 2.27e-05 | 6.28e-04 | 54 |
GO:00609683 | Lung | IAC | regulation of gene silencing | 22/2061 | 81/18723 | 4.37e-05 | 1.04e-03 | 22 |
GO:00609652 | Lung | IAC | negative regulation of gene silencing by miRNA | 10/2061 | 22/18723 | 4.73e-05 | 1.09e-03 | 10 |
GO:00601492 | Lung | IAC | negative regulation of posttranscriptional gene silencing | 10/2061 | 24/18723 | 1.17e-04 | 2.22e-03 | 10 |
GO:00609672 | Lung | IAC | negative regulation of gene silencing by RNA | 10/2061 | 24/18723 | 1.17e-04 | 2.22e-03 | 10 |
GO:0060969 | Lung | IAC | negative regulation of gene silencing | 10/2061 | 29/18723 | 7.11e-04 | 9.50e-03 | 10 |
GO:00105872 | Lung | IAC | miRNA catabolic process | 6/2061 | 12/18723 | 9.06e-04 | 1.11e-02 | 6 |
GO:00346557 | Lung | IAC | nucleobase-containing compound catabolic process | 63/2061 | 407/18723 | 3.31e-03 | 2.84e-02 | 63 |
GO:20006281 | Lung | IAC | regulation of miRNA metabolic process | 5/2061 | 12/18723 | 6.55e-03 | 4.60e-02 | 5 |
GO:000989613 | Lung | AIS | positive regulation of catabolic process | 103/1849 | 492/18723 | 9.59e-14 | 1.86e-10 | 103 |
GO:003133113 | Lung | AIS | positive regulation of cellular catabolic process | 89/1849 | 427/18723 | 6.12e-12 | 4.46e-09 | 89 |
GO:006096412 | Lung | AIS | regulation of gene silencing by miRNA | 16/1849 | 49/18723 | 1.08e-05 | 4.40e-04 | 16 |
GO:006014712 | Lung | AIS | regulation of posttranscriptional gene silencing | 16/1849 | 52/18723 | 2.51e-05 | 8.13e-04 | 16 |
GO:006096612 | Lung | AIS | regulation of gene silencing by RNA | 16/1849 | 53/18723 | 3.27e-05 | 1.01e-03 | 16 |
GO:006096811 | Lung | AIS | regulation of gene silencing | 19/1849 | 81/18723 | 2.73e-04 | 5.19e-03 | 19 |