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Gene: HSPB8 |
Gene summary for HSPB8 |
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Gene information | Species | Human | Gene symbol | HSPB8 | Gene ID | 26353 |
Gene name | heat shock protein family B (small) member 8 | |
Gene Alias | CMT2L | |
Cytomap | 12q24.23 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | Q9UJY1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26353 | HSPB8 | AEH-subject1 | Human | Endometrium | AEH | 1.50e-33 | 9.05e-01 | -0.3059 |
26353 | HSPB8 | AEH-subject2 | Human | Endometrium | AEH | 1.06e-07 | 3.57e-01 | -0.2525 |
26353 | HSPB8 | AEH-subject3 | Human | Endometrium | AEH | 1.23e-09 | 4.42e-01 | -0.2576 |
26353 | HSPB8 | AEH-subject4 | Human | Endometrium | AEH | 3.97e-02 | 2.43e-01 | -0.2657 |
26353 | HSPB8 | EEC-subject1 | Human | Endometrium | EEC | 1.19e-09 | 5.13e-01 | -0.2682 |
26353 | HSPB8 | EEC-subject2 | Human | Endometrium | EEC | 1.29e-03 | 2.69e-01 | -0.2607 |
26353 | HSPB8 | EEC-subject5 | Human | Endometrium | EEC | 7.46e-10 | 3.98e-01 | -0.249 |
26353 | HSPB8 | LZE4T | Human | Esophagus | ESCC | 1.11e-04 | -5.46e-01 | 0.0811 |
26353 | HSPB8 | LZE8T | Human | Esophagus | ESCC | 1.19e-02 | -1.71e-01 | 0.067 |
26353 | HSPB8 | P2T-E | Human | Esophagus | ESCC | 1.17e-06 | 5.55e-01 | 0.1177 |
26353 | HSPB8 | P4T-E | Human | Esophagus | ESCC | 1.07e-30 | 1.43e+00 | 0.1323 |
26353 | HSPB8 | P5T-E | Human | Esophagus | ESCC | 2.63e-24 | 1.15e+00 | 0.1327 |
26353 | HSPB8 | P8T-E | Human | Esophagus | ESCC | 1.96e-12 | 6.28e-01 | 0.0889 |
26353 | HSPB8 | P10T-E | Human | Esophagus | ESCC | 2.84e-04 | -4.28e-01 | 0.116 |
26353 | HSPB8 | P11T-E | Human | Esophagus | ESCC | 5.00e-12 | 1.92e+00 | 0.1426 |
26353 | HSPB8 | P12T-E | Human | Esophagus | ESCC | 2.11e-02 | -4.25e-01 | 0.1122 |
26353 | HSPB8 | P16T-E | Human | Esophagus | ESCC | 2.09e-14 | -4.75e-01 | 0.1153 |
26353 | HSPB8 | P19T-E | Human | Esophagus | ESCC | 1.07e-03 | 9.74e-01 | 0.1662 |
26353 | HSPB8 | P21T-E | Human | Esophagus | ESCC | 2.22e-05 | 4.61e-01 | 0.1617 |
26353 | HSPB8 | P22T-E | Human | Esophagus | ESCC | 2.85e-07 | -3.92e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00105089 | Skin | cSCC | positive regulation of autophagy | 45/4864 | 124/18723 | 7.08e-03 | 3.40e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPB8 | SNV | Missense_Mutation | novel | c.330N>C | p.Leu110Phe | p.L110F | Q9UJY1 | protein_coding | deleterious(0.04) | benign(0.376) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
HSPB8 | SNV | Missense_Mutation | rs757293016 | c.250N>A | p.Glu84Lys | p.E84K | Q9UJY1 | protein_coding | tolerated(0.84) | benign(0.017) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HSPB8 | SNV | Missense_Mutation | c.86N>A | p.Arg29His | p.R29H | Q9UJY1 | protein_coding | deleterious(0.04) | possibly_damaging(0.541) | TCGA-AG-3727-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
HSPB8 | SNV | Missense_Mutation | c.374N>T | p.His125Leu | p.H125L | Q9UJY1 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-EI-6513-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
HSPB8 | SNV | Missense_Mutation | c.485N>A | p.Gly162Asp | p.G162D | Q9UJY1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HSPB8 | insertion | Frame_Shift_Ins | rs773017653 | c.259_260insC | p.Pro90ThrfsTer37 | p.P90Tfs*37 | Q9UJY1 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
HSPB8 | insertion | Frame_Shift_Ins | rs773017653 | c.259_260insC | p.Pro90ThrfsTer37 | p.P90Tfs*37 | Q9UJY1 | protein_coding | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HSPB8 | insertion | Frame_Shift_Ins | rs773017653 | c.266dupC | p.Pro90ThrfsTer37 | p.P90Tfs*37 | Q9UJY1 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HSPB8 | SNV | Missense_Mutation | novel | c.452C>T | p.Pro151Leu | p.P151L | Q9UJY1 | protein_coding | tolerated(0.28) | probably_damaging(0.976) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HSPB8 | SNV | Missense_Mutation | c.215G>T | p.Gly72Val | p.G72V | Q9UJY1 | protein_coding | tolerated(0.57) | benign(0) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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