Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/HK1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/HK1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/HK1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/HK1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HK1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HK1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/HK1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HK1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HK1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006007 | Colorectum | FAP | glucose catabolic process | 9/2622 | 19/18723 | 4.99e-04 | 5.72e-03 | 9 |
GO:0046365 | Colorectum | FAP | monosaccharide catabolic process | 14/2622 | 40/18723 | 6.94e-04 | 7.50e-03 | 14 |
GO:00067351 | Colorectum | FAP | NADH regeneration | 6/2622 | 10/18723 | 9.48e-04 | 9.39e-03 | 6 |
GO:00616211 | Colorectum | FAP | canonical glycolysis | 6/2622 | 10/18723 | 9.48e-04 | 9.39e-03 | 6 |
GO:00617181 | Colorectum | FAP | glucose catabolic process to pyruvate | 6/2622 | 10/18723 | 9.48e-04 | 9.39e-03 | 6 |
GO:00067343 | Colorectum | FAP | NADH metabolic process | 11/2622 | 29/18723 | 1.20e-03 | 1.14e-02 | 11 |
GO:00196741 | Colorectum | FAP | NAD metabolic process | 11/2622 | 30/18723 | 1.66e-03 | 1.46e-02 | 11 |
GO:00516513 | Colorectum | FAP | maintenance of location in cell | 46/2622 | 214/18723 | 1.76e-03 | 1.53e-02 | 46 |
GO:0061620 | Colorectum | FAP | glycolytic process through glucose-6-phosphate | 6/2622 | 12/18723 | 3.24e-03 | 2.40e-02 | 6 |
GO:0061615 | Colorectum | FAP | glycolytic process through fructose-6-phosphate | 6/2622 | 13/18723 | 5.32e-03 | 3.49e-02 | 6 |
GO:00460315 | Colorectum | CRC | ADP metabolic process | 28/2078 | 90/18723 | 2.43e-07 | 2.27e-05 | 28 |
GO:00091505 | Colorectum | CRC | purine ribonucleotide metabolic process | 74/2078 | 368/18723 | 2.58e-07 | 2.38e-05 | 74 |
GO:00061635 | Colorectum | CRC | purine nucleotide metabolic process | 78/2078 | 396/18723 | 2.98e-07 | 2.59e-05 | 78 |
GO:00060965 | Colorectum | CRC | glycolytic process | 26/2078 | 81/18723 | 3.26e-07 | 2.79e-05 | 26 |
GO:00067575 | Colorectum | CRC | ATP generation from ADP | 26/2078 | 82/18723 | 4.27e-07 | 3.37e-05 | 26 |
GO:00091355 | Colorectum | CRC | purine nucleoside diphosphate metabolic process | 30/2078 | 103/18723 | 4.56e-07 | 3.39e-05 | 30 |
GO:00091795 | Colorectum | CRC | purine ribonucleoside diphosphate metabolic process | 30/2078 | 103/18723 | 4.56e-07 | 3.39e-05 | 30 |
GO:00092594 | Colorectum | CRC | ribonucleotide metabolic process | 75/2078 | 385/18723 | 7.83e-07 | 5.04e-05 | 75 |
GO:00091855 | Colorectum | CRC | ribonucleoside diphosphate metabolic process | 30/2078 | 106/18723 | 8.96e-07 | 5.71e-05 | 30 |
GO:00725215 | Colorectum | CRC | purine-containing compound metabolic process | 79/2078 | 416/18723 | 1.15e-06 | 6.75e-05 | 79 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HK1 | SNV | Missense_Mutation | novel | c.862G>A | p.Gly288Arg | p.G288R | P19367 | protein_coding | tolerated(0.21) | probably_damaging(0.982) | TCGA-A7-A4SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
HK1 | SNV | Missense_Mutation | | c.100C>T | p.Arg34Trp | p.R34W | P19367 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-A7-A6VV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
HK1 | SNV | Missense_Mutation | novel | c.2692N>C | p.Glu898Gln | p.E898Q | P19367 | protein_coding | deleterious(0.01) | probably_damaging(0.958) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
HK1 | deletion | Frame_Shift_Del | novel | c.797delG | p.Gly266GlufsTer9 | p.G266Efs*9 | P19367 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
HK1 | SNV | Missense_Mutation | rs747689299 | c.1414C>T | p.Arg472Trp | p.R472W | P19367 | protein_coding | deleterious(0.01) | probably_damaging(0.945) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HK1 | SNV | Missense_Mutation | rs867948527 | c.2740C>T | p.Arg914Trp | p.R914W | P19367 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HK1 | SNV | Missense_Mutation | novel | c.703G>A | p.Gly235Ser | p.G235S | P19367 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HK1 | SNV | Missense_Mutation | rs146727978 | c.2548N>T | p.Arg850Cys | p.R850C | P19367 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HK1 | SNV | Missense_Mutation | novel | c.1492G>A | p.Glu498Lys | p.E498K | P19367 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HK1 | SNV | Missense_Mutation | novel | c.932G>A | p.Arg311Gln | p.R311Q | P19367 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |