Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/GPSM2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/GPSM2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GPSM2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/GPSM2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/GPSM2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/GPSM2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00328863 | Oral cavity | OSCC | regulation of microtubule-based process | 115/7305 | 240/18723 | 2.95e-03 | 1.28e-02 | 115 |
GO:0072697 | Oral cavity | OSCC | protein localization to cell cortex | 9/7305 | 11/18723 | 4.85e-03 | 1.92e-02 | 9 |
GO:0051294 | Oral cavity | OSCC | establishment of spindle orientation | 22/7305 | 37/18723 | 9.34e-03 | 3.34e-02 | 22 |
GO:00516532 | Oral cavity | OSCC | spindle localization | 31/7305 | 56/18723 | 9.53e-03 | 3.39e-02 | 31 |
GO:0040001 | Oral cavity | OSCC | establishment of mitotic spindle localization | 21/7305 | 35/18723 | 9.58e-03 | 3.40e-02 | 21 |
GO:1903829110 | Oral cavity | LP | positive regulation of cellular protein localization | 127/4623 | 276/18723 | 7.52e-15 | 9.81e-13 | 127 |
GO:199077817 | Oral cavity | LP | protein localization to cell periphery | 133/4623 | 333/18723 | 4.42e-10 | 2.21e-08 | 133 |
GO:005165615 | Oral cavity | LP | establishment of organelle localization | 147/4623 | 390/18723 | 6.01e-09 | 2.46e-07 | 147 |
GO:190285014 | Oral cavity | LP | microtubule cytoskeleton organization involved in mitosis | 63/4623 | 147/18723 | 9.97e-07 | 2.50e-05 | 63 |
GO:190437517 | Oral cavity | LP | regulation of protein localization to cell periphery | 55/4623 | 125/18723 | 1.77e-06 | 4.11e-05 | 55 |
GO:000705213 | Oral cavity | LP | mitotic spindle organization | 53/4623 | 120/18723 | 2.36e-06 | 5.22e-05 | 53 |
GO:006023613 | Oral cavity | LP | regulation of mitotic spindle organization | 21/4623 | 35/18723 | 9.42e-06 | 1.75e-04 | 21 |
GO:000705113 | Oral cavity | LP | spindle organization | 72/4623 | 184/18723 | 9.67e-06 | 1.78e-04 | 72 |
GO:190211513 | Oral cavity | LP | regulation of organelle assembly | 71/4623 | 186/18723 | 2.94e-05 | 4.58e-04 | 71 |
GO:009016913 | Oral cavity | LP | regulation of spindle assembly | 16/4623 | 25/18723 | 3.61e-05 | 5.36e-04 | 16 |
GO:005149519 | Oral cavity | LP | positive regulation of cytoskeleton organization | 82/4623 | 226/18723 | 6.26e-05 | 8.46e-04 | 82 |
GO:009022412 | Oral cavity | LP | regulation of spindle organization | 21/4623 | 39/18723 | 8.80e-05 | 1.11e-03 | 21 |
GO:000716319 | Oral cavity | LP | establishment or maintenance of cell polarity | 79/4623 | 218/18723 | 8.84e-05 | 1.11e-03 | 79 |
GO:005123519 | Oral cavity | LP | maintenance of location | 111/4623 | 327/18723 | 9.62e-05 | 1.20e-03 | 111 |
GO:0051651110 | Oral cavity | LP | maintenance of location in cell | 74/4623 | 214/18723 | 7.18e-04 | 6.41e-03 | 74 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPSM2 | SNV | Missense_Mutation | | c.1114C>G | p.Gln372Glu | p.Q372E | P81274 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GPSM2 | SNV | Missense_Mutation | | c.1463G>C | p.Gly488Ala | p.G488A | P81274 | protein_coding | tolerated(0.14) | benign(0.011) | TCGA-AO-A0J3-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | SD |
GPSM2 | SNV | Missense_Mutation | | c.1629C>A | p.Asn543Lys | p.N543K | P81274 | protein_coding | tolerated(0.49) | benign(0.015) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPSM2 | SNV | Missense_Mutation | rs867670266 | c.815N>T | p.Ala272Val | p.A272V | P81274 | protein_coding | tolerated(0.06) | probably_damaging(0.948) | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPSM2 | SNV | Missense_Mutation | | c.1672N>A | p.Arg558Ser | p.R558S | P81274 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPSM2 | SNV | Missense_Mutation | | c.1258N>A | p.Glu420Lys | p.E420K | P81274 | protein_coding | tolerated(0.1) | benign(0.08) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPSM2 | SNV | Missense_Mutation | | c.970N>A | p.Ala324Thr | p.A324T | P81274 | protein_coding | deleterious(0.02) | benign(0.241) | TCGA-E2-A152-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | PD |
GPSM2 | SNV | Missense_Mutation | | c.1778C>A | p.Ala593Asp | p.A593D | P81274 | protein_coding | deleterious(0.03) | benign(0.078) | TCGA-E2-A15L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
GPSM2 | SNV | Missense_Mutation | novel | c.1525T>C | p.Cys509Arg | p.C509R | P81274 | protein_coding | deleterious(0) | possibly_damaging(0.677) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GPSM2 | SNV | Missense_Mutation | novel | c.1673G>C | p.Arg558Pro | p.R558P | P81274 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |