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Gene: GPD1L |
Gene summary for GPD1L |
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Gene information | Species | Human | Gene symbol | GPD1L | Gene ID | 23171 |
Gene name | glycerol-3-phosphate dehydrogenase 1 like | |
Gene Alias | GPD1-L | |
Cytomap | 3p22.3 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | Q8N335 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23171 | GPD1L | HTA11_347_2000001011 | Human | Colorectum | AD | 1.09e-07 | 4.04e-01 | -0.1954 |
23171 | GPD1L | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.04e-07 | -3.12e-01 | 0.3005 |
23171 | GPD1L | A001-C-207 | Human | Colorectum | FAP | 2.21e-04 | -3.02e-01 | 0.1278 |
23171 | GPD1L | A015-C-203 | Human | Colorectum | FAP | 1.41e-17 | -2.94e-01 | -0.1294 |
23171 | GPD1L | A002-C-201 | Human | Colorectum | FAP | 1.74e-08 | -2.86e-01 | 0.0324 |
23171 | GPD1L | A002-C-203 | Human | Colorectum | FAP | 1.05e-03 | -1.42e-01 | 0.2786 |
23171 | GPD1L | A001-C-119 | Human | Colorectum | FAP | 9.72e-08 | -3.84e-01 | -0.1557 |
23171 | GPD1L | A001-C-108 | Human | Colorectum | FAP | 1.90e-11 | -2.66e-01 | -0.0272 |
23171 | GPD1L | A002-C-205 | Human | Colorectum | FAP | 9.75e-11 | -3.11e-01 | -0.1236 |
23171 | GPD1L | A001-C-104 | Human | Colorectum | FAP | 8.59e-07 | -3.00e-01 | 0.0184 |
23171 | GPD1L | A015-C-005 | Human | Colorectum | FAP | 3.09e-03 | -2.49e-01 | -0.0336 |
23171 | GPD1L | A015-C-006 | Human | Colorectum | FAP | 5.45e-09 | -3.86e-01 | -0.0994 |
23171 | GPD1L | A015-C-106 | Human | Colorectum | FAP | 1.65e-07 | -2.05e-01 | -0.0511 |
23171 | GPD1L | A002-C-114 | Human | Colorectum | FAP | 1.00e-06 | -2.47e-01 | -0.1561 |
23171 | GPD1L | A015-C-104 | Human | Colorectum | FAP | 6.61e-21 | -3.62e-01 | -0.1899 |
23171 | GPD1L | A001-C-014 | Human | Colorectum | FAP | 1.28e-13 | -3.32e-01 | 0.0135 |
23171 | GPD1L | A002-C-016 | Human | Colorectum | FAP | 1.71e-13 | -2.91e-01 | 0.0521 |
23171 | GPD1L | A015-C-002 | Human | Colorectum | FAP | 5.14e-05 | -3.38e-01 | -0.0763 |
23171 | GPD1L | A001-C-203 | Human | Colorectum | FAP | 8.99e-09 | -2.28e-01 | -0.0481 |
23171 | GPD1L | A002-C-116 | Human | Colorectum | FAP | 8.97e-18 | -2.89e-01 | -0.0452 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1901136 | Liver | HCC | carbohydrate derivative catabolic process | 98/7958 | 172/18723 | 8.71e-05 | 7.62e-04 | 98 |
GO:00464342 | Liver | HCC | organophosphate catabolic process | 89/7958 | 155/18723 | 1.24e-04 | 1.03e-03 | 89 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
GO:0052646 | Liver | HCC | alditol phosphate metabolic process | 9/7958 | 11/18723 | 9.51e-03 | 3.60e-02 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPD1L | SNV | Missense_Mutation | novel | c.322N>G | p.Thr108Ala | p.T108A | Q8N335 | protein_coding | tolerated(0.25) | benign(0) | TCGA-A8-A0AB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
GPD1L | insertion | Frame_Shift_Ins | novel | c.331_332insAGGGGGC | p.Val111GlufsTer28 | p.V111Efs*28 | Q8N335 | protein_coding | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GPD1L | insertion | In_Frame_Ins | novel | c.333_334insGTGAGGTGGGAGAGCAACAGAGAGCAA | p.Val111_Pro112insValArgTrpGluSerAsnArgGluGln | p.V111_P112insVRWESNREQ | Q8N335 | protein_coding | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GPD1L | insertion | Nonsense_Mutation | novel | c.323_324insCTTTTGCAGATAAGGCAGT | p.Gly109PhefsTer4 | p.G109Ffs*4 | Q8N335 | protein_coding | TCGA-A8-A0AB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
GPD1L | insertion | Frame_Shift_Ins | novel | c.920_921insTGGAAATGATTGCTTTTGCC | p.Glu307AspfsTer100 | p.E307Dfs*100 | Q8N335 | protein_coding | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
GPD1L | insertion | Frame_Shift_Ins | novel | c.922_923insGATC | p.Val308GlyfsTer48 | p.V308Gfs*48 | Q8N335 | protein_coding | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
GPD1L | insertion | Frame_Shift_Ins | novel | c.268_269insA | p.Leu90HisfsTer16 | p.L90Hfs*16 | Q8N335 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
GPD1L | insertion | Frame_Shift_Ins | novel | c.269_270insGGCCTTAGAAAGGGGCTGCCTGGCAGCAGGGACA | p.Leu91AlafsTer26 | p.L91Afs*26 | Q8N335 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
GPD1L | insertion | In_Frame_Ins | novel | c.915_916insTCAATTTTGCCATCCACTCCCCTGGCCTGG | p.Ser305_Ala306insSerIleLeuProSerThrProLeuAlaTrp | p.S305_A306insSILPSTPLAW | Q8N335 | protein_coding | TCGA-E9-A1R2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR | ||
GPD1L | SNV | Missense_Mutation | novel | c.96G>T | p.Gln32His | p.Q32H | Q8N335 | protein_coding | tolerated(0.24) | benign(0.157) | TCGA-EK-A2RL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | taxol | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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