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Gene: GOT1 |
Gene summary for GOT1 |
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Gene information | Species | Human | Gene symbol | GOT1 | Gene ID | 2805 |
Gene name | glutamic-oxaloacetic transaminase 1 | |
Gene Alias | AST1 | |
Cytomap | 10q24.2 | |
Gene Type | protein-coding | GO ID | GO:0003254 | UniProtAcc | A0A140VK69 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2805 | GOT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.21e-04 | 3.78e-01 | -0.1954 |
2805 | GOT1 | A002-C-010 | Human | Colorectum | FAP | 2.16e-02 | -1.51e-01 | 0.242 |
2805 | GOT1 | A001-C-207 | Human | Colorectum | FAP | 9.81e-04 | -2.77e-01 | 0.1278 |
2805 | GOT1 | A015-C-203 | Human | Colorectum | FAP | 6.79e-12 | -2.63e-01 | -0.1294 |
2805 | GOT1 | A015-C-204 | Human | Colorectum | FAP | 5.57e-08 | -3.35e-01 | -0.0228 |
2805 | GOT1 | A002-C-201 | Human | Colorectum | FAP | 3.26e-08 | -3.04e-01 | 0.0324 |
2805 | GOT1 | A002-C-203 | Human | Colorectum | FAP | 1.63e-09 | -3.02e-01 | 0.2786 |
2805 | GOT1 | A001-C-119 | Human | Colorectum | FAP | 1.79e-07 | -3.60e-01 | -0.1557 |
2805 | GOT1 | A001-C-108 | Human | Colorectum | FAP | 7.33e-08 | -2.90e-01 | -0.0272 |
2805 | GOT1 | A002-C-205 | Human | Colorectum | FAP | 2.31e-14 | -3.80e-01 | -0.1236 |
2805 | GOT1 | A001-C-104 | Human | Colorectum | FAP | 2.21e-02 | -2.97e-01 | 0.0184 |
2805 | GOT1 | A015-C-005 | Human | Colorectum | FAP | 3.36e-02 | -1.87e-01 | -0.0336 |
2805 | GOT1 | A015-C-006 | Human | Colorectum | FAP | 2.23e-07 | -3.03e-01 | -0.0994 |
2805 | GOT1 | A015-C-106 | Human | Colorectum | FAP | 7.52e-07 | -2.79e-01 | -0.0511 |
2805 | GOT1 | A002-C-114 | Human | Colorectum | FAP | 5.86e-10 | -3.21e-01 | -0.1561 |
2805 | GOT1 | A015-C-104 | Human | Colorectum | FAP | 4.58e-13 | -3.08e-01 | -0.1899 |
2805 | GOT1 | A001-C-014 | Human | Colorectum | FAP | 2.37e-08 | -3.33e-01 | 0.0135 |
2805 | GOT1 | A002-C-016 | Human | Colorectum | FAP | 2.56e-08 | -2.99e-01 | 0.0521 |
2805 | GOT1 | A015-C-002 | Human | Colorectum | FAP | 2.99e-05 | -2.80e-01 | -0.0763 |
2805 | GOT1 | A001-C-203 | Human | Colorectum | FAP | 3.66e-07 | -2.94e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000717810 | Esophagus | ESCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 195/8552 | 355/18723 | 2.58e-04 | 1.58e-03 | 195 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:000961216 | Esophagus | ESCC | response to mechanical stimulus | 124/8552 | 216/18723 | 3.30e-04 | 1.94e-03 | 124 |
GO:19016075 | Esophagus | ESCC | alpha-amino acid biosynthetic process | 45/8552 | 68/18723 | 5.13e-04 | 2.84e-03 | 45 |
GO:00305115 | Esophagus | ESCC | positive regulation of transforming growth factor beta receptor signaling pathway | 24/8552 | 32/18723 | 7.22e-04 | 3.77e-03 | 24 |
GO:19038465 | Esophagus | ESCC | positive regulation of cellular response to transforming growth factor beta stimulus | 24/8552 | 32/18723 | 7.22e-04 | 3.77e-03 | 24 |
GO:00461653 | Esophagus | ESCC | alcohol biosynthetic process | 83/8552 | 140/18723 | 8.04e-04 | 4.16e-03 | 83 |
GO:00090674 | Esophagus | ESCC | aspartate family amino acid biosynthetic process | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:00170156 | Esophagus | ESCC | regulation of transforming growth factor beta receptor signaling pathway | 75/8552 | 128/18723 | 2.19e-03 | 9.71e-03 | 75 |
GO:003196020 | Esophagus | ESCC | response to corticosteroid | 95/8552 | 167/18723 | 2.27e-03 | 9.99e-03 | 95 |
GO:00436485 | Esophagus | ESCC | dicarboxylic acid metabolic process | 58/8552 | 96/18723 | 2.55e-03 | 1.09e-02 | 58 |
GO:005138420 | Esophagus | ESCC | response to glucocorticoid | 85/8552 | 148/18723 | 2.60e-03 | 1.11e-02 | 85 |
GO:00329631 | Esophagus | ESCC | collagen metabolic process | 62/8552 | 104/18723 | 2.90e-03 | 1.22e-02 | 62 |
GO:19038447 | Esophagus | ESCC | regulation of cellular response to transforming growth factor beta stimulus | 76/8552 | 131/18723 | 2.96e-03 | 1.24e-02 | 76 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:0009743111 | Esophagus | ESCC | response to carbohydrate | 135/8552 | 253/18723 | 8.16e-03 | 2.89e-02 | 135 |
GO:00346372 | Esophagus | ESCC | cellular carbohydrate biosynthetic process | 46/8552 | 78/18723 | 1.24e-02 | 4.13e-02 | 46 |
GO:00463953 | Liver | NAFLD | carboxylic acid catabolic process | 73/1882 | 236/18723 | 4.16e-19 | 1.22e-15 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00330 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
hsa01230 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa003301 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
hsa012301 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa012006 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
hsa003306 | Colorectum | FAP | Arginine and proline metabolism | 16/1404 | 50/8465 | 5.33e-03 | 2.10e-02 | 1.27e-02 | 16 |
hsa012007 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
hsa003307 | Colorectum | FAP | Arginine and proline metabolism | 16/1404 | 50/8465 | 5.33e-03 | 2.10e-02 | 1.27e-02 | 16 |
hsa012008 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa012009 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa0120016 | Esophagus | HGIN | Carbon metabolism | 31/1383 | 115/8465 | 2.51e-03 | 2.10e-02 | 1.67e-02 | 31 |
hsa012306 | Esophagus | HGIN | Biosynthesis of amino acids | 21/1383 | 75/8465 | 7.38e-03 | 4.63e-02 | 3.68e-02 | 21 |
hsa0120017 | Esophagus | HGIN | Carbon metabolism | 31/1383 | 115/8465 | 2.51e-03 | 2.10e-02 | 1.67e-02 | 31 |
hsa0123013 | Esophagus | HGIN | Biosynthesis of amino acids | 21/1383 | 75/8465 | 7.38e-03 | 4.63e-02 | 3.68e-02 | 21 |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0123023 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0120033 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0123033 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GOT1 | SNV | Missense_Mutation | novel | c.955G>A | p.Glu319Lys | p.E319K | P17174 | protein_coding | deleterious(0.01) | benign(0.333) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GOT1 | SNV | Missense_Mutation | novel | c.508G>A | p.Asp170Asn | p.D170N | P17174 | protein_coding | tolerated(0.17) | benign(0.089) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GOT1 | SNV | Missense_Mutation | rs776949680 | c.1002N>A | p.Met334Ile | p.M334I | P17174 | protein_coding | deleterious(0) | possibly_damaging(0.688) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GOT1 | SNV | Missense_Mutation | c.1172N>A | p.Ser391Asn | p.S391N | P17174 | protein_coding | deleterious(0) | benign(0.3) | TCGA-A6-5659-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GOT1 | SNV | Missense_Mutation | c.253N>G | p.Ser85Ala | p.S85A | P17174 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
GOT1 | SNV | Missense_Mutation | c.535N>A | p.Glu179Lys | p.E179K | P17174 | protein_coding | tolerated(0.69) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
GOT1 | SNV | Missense_Mutation | c.687N>A | p.Phe229Leu | p.F229L | P17174 | protein_coding | deleterious(0.03) | benign(0.321) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GOT1 | SNV | Missense_Mutation | rs769200718 | c.914N>A | p.Arg305Gln | p.R305Q | P17174 | protein_coding | deleterious(0.01) | possibly_damaging(0.74) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GOT1 | SNV | Missense_Mutation | novel | c.125N>A | p.Arg42His | p.R42H | P17174 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GOT1 | SNV | Missense_Mutation | rs772704095 | c.688G>A | p.Ala230Thr | p.A230T | P17174 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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