|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: GMPR |
Gene summary for GMPR |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GMPR | Gene ID | 2766 |
| Gene name | guanosine monophosphate reductase | |
| Gene Alias | GMPR 1 | |
| Cytomap | 6p22.3 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P36959 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2766 | GMPR | HTA11_696_2000001011 | Human | Colorectum | AD | 1.80e-05 | 2.11e-01 | -0.1464 |
| 2766 | GMPR | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.82e-04 | 3.06e-01 | -0.059 |
| 2766 | GMPR | HTA11_866_3004761011 | Human | Colorectum | AD | 8.51e-07 | 3.00e-01 | 0.096 |
| 2766 | GMPR | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.56e-03 | 4.73e-01 | 0.0446 |
| 2766 | GMPR | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.10e-04 | 2.80e-01 | 0.0338 |
| 2766 | GMPR | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.75e-15 | 4.20e-01 | 0.0674 |
| 2766 | GMPR | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.47e-64 | 1.27e+00 | 0.294 |
| 2766 | GMPR | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.53e-06 | 1.20e+00 | 0.3487 |
| 2766 | GMPR | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.87e-06 | 3.72e-01 | 0.281 |
| 2766 | GMPR | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.82e-09 | 3.25e-01 | 0.3859 |
| 2766 | GMPR | CRC-3-11773 | Human | Colorectum | CRC | 1.08e-05 | 3.65e-01 | 0.2564 |
| 2766 | GMPR | P2T-E | Human | Esophagus | ESCC | 5.30e-53 | 1.12e+00 | 0.1177 |
| 2766 | GMPR | P10T-E | Human | Esophagus | ESCC | 2.83e-02 | 2.15e-02 | 0.116 |
| 2766 | GMPR | P16T-E | Human | Esophagus | ESCC | 1.34e-07 | 1.22e-01 | 0.1153 |
| 2766 | GMPR | P24T-E | Human | Esophagus | ESCC | 2.50e-07 | 2.26e-01 | 0.1287 |
| 2766 | GMPR | P26T-E | Human | Esophagus | ESCC | 8.67e-03 | 1.17e-01 | 0.1276 |
| 2766 | GMPR | P27T-E | Human | Esophagus | ESCC | 1.41e-02 | 1.60e-01 | 0.1055 |
| 2766 | GMPR | P31T-E | Human | Esophagus | ESCC | 5.62e-06 | 1.26e-01 | 0.1251 |
| 2766 | GMPR | P37T-E | Human | Esophagus | ESCC | 7.77e-03 | 8.01e-02 | 0.1371 |
| 2766 | GMPR | P40T-E | Human | Esophagus | ESCC | 1.22e-05 | 3.37e-01 | 0.109 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00091125 | Skin | cSCC | nucleobase metabolic process | 16/4864 | 34/18723 | 6.47e-03 | 3.15e-02 | 16 |
| GO:001969327 | Thyroid | PTC | ribose phosphate metabolic process | 176/5968 | 396/18723 | 8.28e-08 | 1.70e-06 | 176 |
| GO:000915028 | Thyroid | PTC | purine ribonucleotide metabolic process | 165/5968 | 368/18723 | 1.03e-07 | 2.05e-06 | 165 |
| GO:007252127 | Thyroid | PTC | purine-containing compound metabolic process | 182/5968 | 416/18723 | 1.92e-07 | 3.51e-06 | 182 |
| GO:000925927 | Thyroid | PTC | ribonucleotide metabolic process | 170/5968 | 385/18723 | 2.32e-07 | 4.08e-06 | 170 |
| GO:000616327 | Thyroid | PTC | purine nucleotide metabolic process | 170/5968 | 396/18723 | 2.02e-06 | 2.75e-05 | 170 |
| GO:000675325 | Thyroid | PTC | nucleoside phosphate metabolic process | 205/5968 | 497/18723 | 5.24e-06 | 6.35e-05 | 205 |
| GO:000911725 | Thyroid | PTC | nucleotide metabolic process | 202/5968 | 489/18723 | 5.46e-06 | 6.60e-05 | 202 |
| GO:000912614 | Thyroid | PTC | purine nucleoside monophosphate metabolic process | 25/5968 | 44/18723 | 5.43e-04 | 3.48e-03 | 25 |
| GO:000916710 | Thyroid | PTC | purine ribonucleoside monophosphate metabolic process | 23/5968 | 41/18723 | 1.14e-03 | 6.65e-03 | 23 |
| GO:00091236 | Thyroid | PTC | nucleoside monophosphate metabolic process | 35/5968 | 76/18723 | 6.68e-03 | 2.89e-02 | 35 |
| GO:001969328 | Thyroid | ATC | ribose phosphate metabolic process | 184/6293 | 396/18723 | 5.87e-08 | 1.05e-06 | 184 |
| GO:000915029 | Thyroid | ATC | purine ribonucleotide metabolic process | 172/6293 | 368/18723 | 9.58e-08 | 1.64e-06 | 172 |
| GO:000925928 | Thyroid | ATC | ribonucleotide metabolic process | 178/6293 | 385/18723 | 1.47e-07 | 2.39e-06 | 178 |
| GO:007252128 | Thyroid | ATC | purine-containing compound metabolic process | 189/6293 | 416/18723 | 2.83e-07 | 4.29e-06 | 189 |
| GO:0006753111 | Thyroid | ATC | nucleoside phosphate metabolic process | 219/6293 | 497/18723 | 5.92e-07 | 8.29e-06 | 219 |
| GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
| GO:000616328 | Thyroid | ATC | purine nucleotide metabolic process | 177/6293 | 396/18723 | 2.39e-06 | 2.82e-05 | 177 |
| GO:000912615 | Thyroid | ATC | purine nucleoside monophosphate metabolic process | 25/6293 | 44/18723 | 1.30e-03 | 6.82e-03 | 25 |
| GO:000916713 | Thyroid | ATC | purine ribonucleoside monophosphate metabolic process | 23/6293 | 41/18723 | 2.53e-03 | 1.16e-02 | 23 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GMPR | SNV | Missense_Mutation | c.925N>G | p.Leu309Val | p.L309V | P36959 | protein_coding | deleterious(0.05) | possibly_damaging(0.778) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| GMPR | deletion | Frame_Shift_Del | novel | c.262delN | p.Phe88LeufsTer12 | p.F88Lfs*12 | P36959 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| GMPR | SNV | Missense_Mutation | c.896G>C | p.Gly299Ala | p.G299A | P36959 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
| GMPR | SNV | Missense_Mutation | novel | c.80N>C | p.Arg27Pro | p.R27P | P36959 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| GMPR | SNV | Missense_Mutation | c.157N>A | p.Ala53Thr | p.A53T | P36959 | protein_coding | deleterious(0.03) | probably_damaging(0.923) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| GMPR | SNV | Missense_Mutation | rs771113752 | c.1027G>A | p.Val343Met | p.V343M | P36959 | protein_coding | tolerated(0.12) | benign(0.045) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| GMPR | SNV | Missense_Mutation | rs372790288 | c.116N>A | p.Arg39Gln | p.R39Q | P36959 | protein_coding | tolerated(0.08) | benign(0.21) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| GMPR | SNV | Missense_Mutation | rs138267551 | c.110N>T | p.Thr37Met | p.T37M | P36959 | protein_coding | deleterious(0.01) | possibly_damaging(0.673) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
| GMPR | SNV | Missense_Mutation | rs140300479 | c.424N>A | p.Val142Met | p.V142M | P36959 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-F4-6806-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | irinotecan | PD |
| GMPR | SNV | Missense_Mutation | rs768978971 | c.668N>T | p.Thr223Met | p.T223M | P36959 | protein_coding | deleterious(0.01) | possibly_damaging(0.843) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
| Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |