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Gene: GIGYF2 |
Gene summary for GIGYF2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | GIGYF2 | Gene ID | 26058 |
| Gene name | GRB10 interacting GYF protein 2 | |
| Gene Alias | GYF2 | |
| Cytomap | 2q37.1 | |
| Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q6Y7W6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 26058 | GIGYF2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.77e-19 | -6.46e-01 | 0.0155 |
| 26058 | GIGYF2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.47e-06 | -5.41e-01 | -0.1808 |
| 26058 | GIGYF2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.14e-02 | -7.21e-01 | 0.0216 |
| 26058 | GIGYF2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.74e-05 | -5.16e-01 | -0.1207 |
| 26058 | GIGYF2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.40e-03 | -6.63e-01 | -0.2061 |
| 26058 | GIGYF2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.07e-04 | -3.72e-01 | 0.096 |
| 26058 | GIGYF2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.91e-05 | -5.23e-01 | 0.0338 |
| 26058 | GIGYF2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.29e-08 | -4.84e-01 | 0.0588 |
| 26058 | GIGYF2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.87e-09 | -4.47e-01 | 0.294 |
| 26058 | GIGYF2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.64e-09 | -4.26e-01 | 0.3005 |
| 26058 | GIGYF2 | A002-C-010 | Human | Colorectum | FAP | 4.19e-02 | -1.85e-01 | 0.242 |
| 26058 | GIGYF2 | A001-C-207 | Human | Colorectum | FAP | 1.92e-04 | -2.56e-01 | 0.1278 |
| 26058 | GIGYF2 | A015-C-203 | Human | Colorectum | FAP | 1.17e-30 | -4.08e-01 | -0.1294 |
| 26058 | GIGYF2 | A015-C-204 | Human | Colorectum | FAP | 4.42e-06 | -2.54e-01 | -0.0228 |
| 26058 | GIGYF2 | A014-C-040 | Human | Colorectum | FAP | 2.03e-08 | -6.08e-01 | -0.1184 |
| 26058 | GIGYF2 | A002-C-201 | Human | Colorectum | FAP | 2.83e-13 | -2.75e-01 | 0.0324 |
| 26058 | GIGYF2 | A002-C-203 | Human | Colorectum | FAP | 1.10e-04 | -1.81e-01 | 0.2786 |
| 26058 | GIGYF2 | A001-C-119 | Human | Colorectum | FAP | 8.65e-07 | 3.82e-02 | -0.1557 |
| 26058 | GIGYF2 | A001-C-108 | Human | Colorectum | FAP | 1.05e-14 | -1.28e-01 | -0.0272 |
| 26058 | GIGYF2 | A002-C-205 | Human | Colorectum | FAP | 6.31e-25 | -2.57e-01 | -0.1236 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00434885 | Colorectum | CRC | regulation of mRNA stability | 40/2078 | 158/18723 | 3.96e-07 | 3.21e-05 | 40 |
| GO:00434875 | Colorectum | CRC | regulation of RNA stability | 41/2078 | 170/18723 | 1.13e-06 | 6.69e-05 | 41 |
| GO:00610143 | Colorectum | CRC | positive regulation of mRNA catabolic process | 25/2078 | 87/18723 | 5.27e-06 | 2.12e-04 | 25 |
| GO:19033133 | Colorectum | CRC | positive regulation of mRNA metabolic process | 30/2078 | 118/18723 | 9.83e-06 | 3.31e-04 | 30 |
| GO:00064175 | Colorectum | CRC | regulation of translation | 82/2078 | 468/18723 | 1.79e-05 | 5.40e-04 | 82 |
| GO:00346555 | Colorectum | CRC | nucleobase-containing compound catabolic process | 73/2078 | 407/18723 | 2.28e-05 | 6.57e-04 | 73 |
| GO:00611573 | Colorectum | CRC | mRNA destabilization | 23/2078 | 84/18723 | 2.93e-05 | 7.73e-04 | 23 |
| GO:00442705 | Colorectum | CRC | cellular nitrogen compound catabolic process | 78/2078 | 451/18723 | 4.48e-05 | 1.07e-03 | 78 |
| GO:00467005 | Colorectum | CRC | heterocycle catabolic process | 77/2078 | 445/18723 | 4.92e-05 | 1.14e-03 | 77 |
| GO:00507793 | Colorectum | CRC | RNA destabilization | 23/2078 | 88/18723 | 6.51e-05 | 1.42e-03 | 23 |
| GO:00602495 | Colorectum | CRC | anatomical structure homeostasis | 57/2078 | 314/18723 | 1.24e-04 | 2.41e-03 | 57 |
| GO:00194395 | Colorectum | CRC | aromatic compound catabolic process | 77/2078 | 467/18723 | 2.42e-04 | 4.00e-03 | 77 |
| GO:19013615 | Colorectum | CRC | organic cyclic compound catabolic process | 80/2078 | 495/18723 | 3.52e-04 | 5.34e-03 | 80 |
| GO:00097914 | Colorectum | CRC | post-embryonic development | 20/2078 | 80/18723 | 3.62e-04 | 5.45e-03 | 20 |
| GO:00018945 | Colorectum | CRC | tissue homeostasis | 48/2078 | 268/18723 | 5.56e-04 | 7.70e-03 | 48 |
| GO:00488725 | Colorectum | CRC | homeostasis of number of cells | 48/2078 | 272/18723 | 7.78e-04 | 9.87e-03 | 48 |
| GO:00342492 | Colorectum | CRC | negative regulation of cellular amide metabolic process | 45/2078 | 273/18723 | 4.35e-03 | 3.47e-02 | 45 |
| GO:00171482 | Colorectum | CRC | negative regulation of translation | 41/2078 | 245/18723 | 4.82e-03 | 3.72e-02 | 41 |
| GO:00352642 | Colorectum | CRC | multicellular organism growth | 25/2078 | 132/18723 | 5.21e-03 | 3.97e-02 | 25 |
| GO:0021953 | Colorectum | CRC | central nervous system neuron differentiation | 29/2078 | 162/18723 | 6.36e-03 | 4.62e-02 | 29 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| GIGYF2 | SNV | Missense_Mutation | novel | c.2206N>T | p.Asp736Tyr | p.D736Y | Q6Y7W6 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| GIGYF2 | SNV | Missense_Mutation | c.1021N>A | p.Glu341Lys | p.E341K | Q6Y7W6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
| GIGYF2 | SNV | Missense_Mutation | rs372418931 | c.3059N>T | p.Thr1020Met | p.T1020M | Q6Y7W6 | protein_coding | tolerated(0.46) | benign(0.441) | TCGA-E2-A15C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
| GIGYF2 | insertion | Nonsense_Mutation | novel | c.3493_3494insTCTCCTGGGCTGGAATGTAGCTAGGACT | p.His1165LeufsTer7 | p.H1165Lfs*7 | Q6Y7W6 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
| GIGYF2 | deletion | Frame_Shift_Del | c.734delN | p.Ala245ValfsTer56 | p.A245Vfs*56 | Q6Y7W6 | protein_coding | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| GIGYF2 | SNV | Missense_Mutation | c.3323N>A | p.Gly1108Glu | p.G1108E | Q6Y7W6 | protein_coding | deleterious(0) | benign(0.015) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
| GIGYF2 | SNV | Missense_Mutation | c.712N>A | p.Glu238Lys | p.E238K | Q6Y7W6 | protein_coding | tolerated(0.1) | possibly_damaging(0.776) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
| GIGYF2 | SNV | Missense_Mutation | rs754519471 | c.2402N>A | p.Arg801Gln | p.R801Q | Q6Y7W6 | protein_coding | tolerated(0.26) | benign(0.297) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| GIGYF2 | SNV | Missense_Mutation | novel | c.937N>A | p.Glu313Lys | p.E313K | Q6Y7W6 | protein_coding | deleterious(0.01) | possibly_damaging(0.857) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
| GIGYF2 | SNV | Missense_Mutation | c.2423N>A | p.Arg808Gln | p.R808Q | Q6Y7W6 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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