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Gene: GCG |
Gene summary for GCG |
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Gene information | Species | Human | Gene symbol | GCG | Gene ID | 2641 |
Gene name | glucagon | |
Gene Alias | GLP-1 | |
Cytomap | 2q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P01275 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2641 | GCG | HTA11_411_2000001011 | Human | Colorectum | SER | 2.19e-03 | 2.31e+00 | -0.2602 |
2641 | GCG | HTA12-23-1 | Human | Pancreas | PDAC | 3.96e-02 | 6.49e-01 | 0.3405 |
2641 | GCG | HTA12-26-1 | Human | Pancreas | PDAC | 2.68e-10 | 8.19e-01 | 0.3728 |
2641 | GCG | HTA12-29-1 | Human | Pancreas | PDAC | 4.16e-08 | 3.25e-01 | 0.3722 |
2641 | GCG | HTA12-9-1 | Human | Pancreas | PDAC | 2.87e-08 | 7.93e-01 | 0.1532 |
2641 | GCG | 4347-EC | Human | Pancreas | PanIN | 7.60e-37 | 1.19e+00 | 0.0572 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00435887 | Oral cavity | OSCC | skin development | 143/7305 | 263/18723 | 2.77e-07 | 4.27e-06 | 143 |
GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
GO:00302166 | Oral cavity | OSCC | keratinocyte differentiation | 81/7305 | 139/18723 | 3.16e-06 | 3.81e-05 | 81 |
GO:00066432 | Oral cavity | OSCC | membrane lipid metabolic process | 111/7305 | 203/18723 | 4.02e-06 | 4.69e-05 | 111 |
GO:00099139 | Oral cavity | OSCC | epidermal cell differentiation | 109/7305 | 202/18723 | 1.08e-05 | 1.14e-04 | 109 |
GO:00421572 | Oral cavity | OSCC | lipoprotein metabolic process | 77/7305 | 135/18723 | 1.61e-05 | 1.60e-04 | 77 |
GO:00064972 | Oral cavity | OSCC | protein lipidation | 56/7305 | 92/18723 | 1.77e-05 | 1.72e-04 | 56 |
GO:00421582 | Oral cavity | OSCC | lipoprotein biosynthetic process | 57/7305 | 96/18723 | 4.17e-05 | 3.61e-04 | 57 |
GO:00066651 | Oral cavity | OSCC | sphingolipid metabolic process | 84/7305 | 155/18723 | 8.64e-05 | 6.61e-04 | 84 |
GO:00464672 | Oral cavity | OSCC | membrane lipid biosynthetic process | 77/7305 | 142/18723 | 1.63e-04 | 1.13e-03 | 77 |
GO:00440917 | Oral cavity | OSCC | membrane biogenesis | 35/7305 | 55/18723 | 1.88e-04 | 1.27e-03 | 35 |
GO:00192214 | Oral cavity | OSCC | cytokine-mediated signaling pathway | 222/7305 | 472/18723 | 2.02e-04 | 1.35e-03 | 222 |
GO:00717098 | Oral cavity | OSCC | membrane assembly | 32/7305 | 50/18723 | 3.02e-04 | 1.89e-03 | 32 |
GO:005087819 | Oral cavity | OSCC | regulation of body fluid levels | 179/7305 | 379/18723 | 6.19e-04 | 3.50e-03 | 179 |
GO:00066641 | Oral cavity | OSCC | glycolipid metabolic process | 53/7305 | 100/18723 | 3.09e-03 | 1.33e-02 | 53 |
GO:19035091 | Oral cavity | OSCC | liposaccharide metabolic process | 53/7305 | 101/18723 | 4.06e-03 | 1.66e-02 | 53 |
GO:0006672 | Oral cavity | OSCC | ceramide metabolic process | 53/7305 | 102/18723 | 5.28e-03 | 2.06e-02 | 53 |
GO:0030148 | Oral cavity | OSCC | sphingolipid biosynthetic process | 53/7305 | 103/18723 | 6.81e-03 | 2.53e-02 | 53 |
GO:00335614 | Oral cavity | OSCC | regulation of water loss via skin | 17/7305 | 27/18723 | 1.01e-02 | 3.49e-02 | 17 |
GO:001922112 | Oral cavity | EOLP | cytokine-mediated signaling pathway | 94/2218 | 472/18723 | 2.36e-07 | 7.37e-06 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa049223 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GCG | SNV | Missense_Mutation | novel | c.322A>T | p.Ser108Cys | p.S108C | P01275 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
GCG | SNV | Missense_Mutation | c.286N>C | p.Glu96Gln | p.E96Q | P01275 | protein_coding | deleterious(0.02) | possibly_damaging(0.849) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
GCG | SNV | Missense_Mutation | c.187N>C | p.Ser63Arg | p.S63R | P01275 | protein_coding | deleterious(0.01) | possibly_damaging(0.776) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
GCG | SNV | Missense_Mutation | c.79N>A | p.Glu27Lys | p.E27K | P01275 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
GCG | SNV | Missense_Mutation | c.462G>C | p.Glu154Asp | p.E154D | P01275 | protein_coding | tolerated(0.91) | benign(0.039) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
GCG | SNV | Missense_Mutation | c.154C>T | p.Arg52Cys | p.R52C | P01275 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GCG | SNV | Missense_Mutation | rs765979783 | c.167G>A | p.Gly56Asp | p.G56D | P01275 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GCG | SNV | Missense_Mutation | c.14N>G | p.Tyr5Cys | p.Y5C | P01275 | protein_coding | tolerated(0.06) | benign(0.26) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GCG | SNV | Missense_Mutation | c.481N>C | p.Asn161His | p.N161H | P01275 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-G4-6310-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fu | SD | |
GCG | SNV | Missense_Mutation | c.449C>A | p.Ser150Tyr | p.S150Y | P01275 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | PC4 | 12665168 | ||
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | ANTIDEPRESSANT | 10889291 | ||
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | SODIUM BUTYRATE | 3550424 | ||
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | NALTREXONE | NALTREXONE | 9623517 | |
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | MK-8521 | |||
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | PB-1023 | |||
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | PYRAZOLE | PYRAZOLE | 6992153 | |
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | BETHANECHOL CHLORIDE | 449696 | ||
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | MORPHINE | MORPHINE | 6993188 | |
2641 | GCG | DRUGGABLE GENOME, HORMONE ACTIVITY | PD 098059 | 10781369 |
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