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Gene: GAR1 |
Gene summary for GAR1 |
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Gene information | Species | Human | Gene symbol | GAR1 | Gene ID | 54433 |
Gene name | GAR1 ribonucleoprotein | |
Gene Alias | NOLA1 | |
Cytomap | 4q25 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | A0A024RDJ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54433 | GAR1 | LZE4T | Human | Esophagus | ESCC | 1.94e-03 | 1.81e-01 | 0.0811 |
54433 | GAR1 | LZE7T | Human | Esophagus | ESCC | 1.92e-06 | 3.01e-01 | 0.0667 |
54433 | GAR1 | LZE8T | Human | Esophagus | ESCC | 1.25e-03 | 1.04e-02 | 0.067 |
54433 | GAR1 | LZE20T | Human | Esophagus | ESCC | 6.55e-06 | 1.79e-02 | 0.0662 |
54433 | GAR1 | LZE22T | Human | Esophagus | ESCC | 9.02e-04 | 1.99e-01 | 0.068 |
54433 | GAR1 | LZE24T | Human | Esophagus | ESCC | 7.65e-14 | 1.52e-01 | 0.0596 |
54433 | GAR1 | LZE6T | Human | Esophagus | ESCC | 4.40e-03 | 1.50e-01 | 0.0845 |
54433 | GAR1 | P1T-E | Human | Esophagus | ESCC | 1.07e-06 | 1.23e-01 | 0.0875 |
54433 | GAR1 | P2T-E | Human | Esophagus | ESCC | 9.43e-23 | 5.70e-01 | 0.1177 |
54433 | GAR1 | P4T-E | Human | Esophagus | ESCC | 6.10e-21 | 6.17e-01 | 0.1323 |
54433 | GAR1 | P5T-E | Human | Esophagus | ESCC | 1.71e-09 | 1.21e-01 | 0.1327 |
54433 | GAR1 | P8T-E | Human | Esophagus | ESCC | 2.50e-20 | 1.67e-01 | 0.0889 |
54433 | GAR1 | P9T-E | Human | Esophagus | ESCC | 5.87e-12 | 2.40e-01 | 0.1131 |
54433 | GAR1 | P10T-E | Human | Esophagus | ESCC | 1.12e-15 | 2.24e-01 | 0.116 |
54433 | GAR1 | P11T-E | Human | Esophagus | ESCC | 9.37e-09 | 1.45e-01 | 0.1426 |
54433 | GAR1 | P12T-E | Human | Esophagus | ESCC | 2.95e-20 | 3.87e-01 | 0.1122 |
54433 | GAR1 | P15T-E | Human | Esophagus | ESCC | 4.17e-20 | 2.58e-01 | 0.1149 |
54433 | GAR1 | P16T-E | Human | Esophagus | ESCC | 5.86e-21 | 3.05e-01 | 0.1153 |
54433 | GAR1 | P17T-E | Human | Esophagus | ESCC | 4.40e-03 | 3.32e-01 | 0.1278 |
54433 | GAR1 | P19T-E | Human | Esophagus | ESCC | 1.49e-05 | 3.82e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466021 | Thyroid | ATC | ncRNA metabolic process | 240/6293 | 485/18723 | 2.03e-13 | 9.91e-12 | 240 |
GO:000072324 | Thyroid | ATC | telomere maintenance | 76/6293 | 131/18723 | 8.21e-09 | 1.75e-07 | 76 |
GO:000700424 | Thyroid | ATC | telomere maintenance via telomerase | 44/6293 | 69/18723 | 2.84e-07 | 4.29e-06 | 44 |
GO:007189723 | Thyroid | ATC | DNA biosynthetic process | 91/6293 | 180/18723 | 1.84e-06 | 2.24e-05 | 91 |
GO:001083326 | Thyroid | ATC | telomere maintenance via telomere lengthening | 47/6293 | 81/18723 | 5.53e-06 | 5.93e-05 | 47 |
GO:000627823 | Thyroid | ATC | RNA-dependent DNA biosynthetic process | 44/6293 | 75/18723 | 7.37e-06 | 7.56e-05 | 44 |
GO:003220016 | Thyroid | ATC | telomere organization | 76/6293 | 159/18723 | 1.40e-04 | 9.75e-04 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GAR1 | SNV | Missense_Mutation | c.31N>G | p.Phe11Val | p.F11V | Q9NY12 | protein_coding | tolerated_low_confidence(0.27) | benign(0.031) | TCGA-A2-A04U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
GAR1 | SNV | Missense_Mutation | c.268A>G | p.Thr90Ala | p.T90A | Q9NY12 | protein_coding | tolerated(0.56) | benign(0.371) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
GAR1 | insertion | Frame_Shift_Ins | novel | c.628_629insAGGTA | p.Gly210GlufsTer12 | p.G210Efs*12 | Q9NY12 | protein_coding | TCGA-AG-A023-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
GAR1 | SNV | Missense_Mutation | c.395N>G | p.Asn132Ser | p.N132S | Q9NY12 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
GAR1 | SNV | Missense_Mutation | c.392N>G | p.Glu131Gly | p.E131G | Q9NY12 | protein_coding | deleterious(0) | possibly_damaging(0.817) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GAR1 | SNV | Missense_Mutation | novel | c.26N>A | p.Gly9Glu | p.G9E | Q9NY12 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.921) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GAR1 | SNV | Missense_Mutation | novel | c.101N>A | p.Gly34Asp | p.G34D | Q9NY12 | protein_coding | tolerated_low_confidence(0.2) | probably_damaging(0.959) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
GAR1 | SNV | Missense_Mutation | c.249N>G | p.Asp83Glu | p.D83E | Q9NY12 | protein_coding | tolerated(1) | possibly_damaging(0.779) | TCGA-38-4629-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GAR1 | SNV | Missense_Mutation | c.554N>A | p.Arg185Lys | p.R185K | Q9NY12 | protein_coding | tolerated_low_confidence(0.24) | benign(0.237) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
GAR1 | SNV | Missense_Mutation | c.514N>T | p.Gly172Cys | p.G172C | Q9NY12 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.887) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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