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Gene: FYTTD1 |
Gene summary for FYTTD1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FYTTD1 | Gene ID | 84248 |
| Gene name | forty-two-three domain containing 1 | |
| Gene Alias | UIF | |
| Cytomap | 3q29 | |
| Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | Q96QD9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84248 | FYTTD1 | LZE2T | Human | Esophagus | ESCC | 2.65e-07 | 1.12e+00 | 0.082 |
| 84248 | FYTTD1 | LZE4T | Human | Esophagus | ESCC | 1.45e-33 | 1.15e+00 | 0.0811 |
| 84248 | FYTTD1 | LZE5T | Human | Esophagus | ESCC | 1.97e-02 | 5.20e-01 | 0.0514 |
| 84248 | FYTTD1 | LZE7T | Human | Esophagus | ESCC | 6.89e-10 | 7.83e-01 | 0.0667 |
| 84248 | FYTTD1 | LZE8T | Human | Esophagus | ESCC | 4.56e-08 | 2.54e-01 | 0.067 |
| 84248 | FYTTD1 | LZE20T | Human | Esophagus | ESCC | 2.43e-09 | 2.38e-01 | 0.0662 |
| 84248 | FYTTD1 | LZE22T | Human | Esophagus | ESCC | 6.07e-05 | 3.21e-01 | 0.068 |
| 84248 | FYTTD1 | LZE24T | Human | Esophagus | ESCC | 1.58e-38 | 1.04e+00 | 0.0596 |
| 84248 | FYTTD1 | LZE21T | Human | Esophagus | ESCC | 8.22e-05 | 5.58e-01 | 0.0655 |
| 84248 | FYTTD1 | LZE6T | Human | Esophagus | ESCC | 1.33e-08 | 2.20e-01 | 0.0845 |
| 84248 | FYTTD1 | P1T-E | Human | Esophagus | ESCC | 2.12e-10 | 5.46e-01 | 0.0875 |
| 84248 | FYTTD1 | P2T-E | Human | Esophagus | ESCC | 3.05e-89 | 1.75e+00 | 0.1177 |
| 84248 | FYTTD1 | P4T-E | Human | Esophagus | ESCC | 6.91e-40 | 1.04e+00 | 0.1323 |
| 84248 | FYTTD1 | P5T-E | Human | Esophagus | ESCC | 3.28e-19 | 6.55e-01 | 0.1327 |
| 84248 | FYTTD1 | P8T-E | Human | Esophagus | ESCC | 1.61e-30 | 7.06e-01 | 0.0889 |
| 84248 | FYTTD1 | P9T-E | Human | Esophagus | ESCC | 4.27e-27 | 6.54e-01 | 0.1131 |
| 84248 | FYTTD1 | P10T-E | Human | Esophagus | ESCC | 1.75e-47 | 9.85e-01 | 0.116 |
| 84248 | FYTTD1 | P11T-E | Human | Esophagus | ESCC | 1.18e-22 | 8.90e-01 | 0.1426 |
| 84248 | FYTTD1 | P12T-E | Human | Esophagus | ESCC | 5.73e-23 | 6.72e-01 | 0.1122 |
| 84248 | FYTTD1 | P15T-E | Human | Esophagus | ESCC | 2.11e-45 | 9.23e-01 | 0.1149 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:007142613 | Skin | cSCC | ribonucleoprotein complex export from nucleus | 48/4864 | 76/18723 | 9.76e-12 | 4.97e-10 | 48 |
| GO:000640513 | Skin | cSCC | RNA export from nucleus | 46/4864 | 84/18723 | 1.89e-08 | 5.56e-07 | 46 |
| GO:003150315 | Skin | cSCC | protein-containing complex localization | 95/4864 | 220/18723 | 2.00e-08 | 5.82e-07 | 95 |
| GO:000640612 | Skin | cSCC | mRNA export from nucleus | 34/4864 | 59/18723 | 2.59e-07 | 5.33e-06 | 34 |
| GO:007142712 | Skin | cSCC | mRNA-containing ribonucleoprotein complex export from nucleus | 34/4864 | 59/18723 | 2.59e-07 | 5.33e-06 | 34 |
| GO:0006913112 | Thyroid | PTC | nucleocytoplasmic transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
| GO:0051169112 | Thyroid | PTC | nuclear transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
| GO:0006403112 | Thyroid | PTC | RNA localization | 130/5968 | 201/18723 | 9.23e-22 | 1.94e-19 | 130 |
| GO:0051168112 | Thyroid | PTC | nuclear export | 102/5968 | 154/18723 | 1.78e-18 | 2.01e-16 | 102 |
| GO:0051236110 | Thyroid | PTC | establishment of RNA localization | 100/5968 | 166/18723 | 4.26e-14 | 2.58e-12 | 100 |
| GO:0050657110 | Thyroid | PTC | nucleic acid transport | 98/5968 | 163/18723 | 9.08e-14 | 4.90e-12 | 98 |
| GO:0050658110 | Thyroid | PTC | RNA transport | 98/5968 | 163/18723 | 9.08e-14 | 4.90e-12 | 98 |
| GO:0015931110 | Thyroid | PTC | nucleobase-containing compound transport | 120/5968 | 222/18723 | 5.45e-12 | 2.35e-10 | 120 |
| GO:005102817 | Thyroid | PTC | mRNA transport | 78/5968 | 130/18723 | 3.44e-11 | 1.26e-09 | 78 |
| GO:00711667 | Thyroid | PTC | ribonucleoprotein complex localization | 47/5968 | 77/18723 | 1.28e-07 | 2.48e-06 | 47 |
| GO:00315037 | Thyroid | PTC | protein-containing complex localization | 107/5968 | 220/18723 | 1.47e-07 | 2.82e-06 | 107 |
| GO:00064058 | Thyroid | PTC | RNA export from nucleus | 50/5968 | 84/18723 | 1.59e-07 | 3.03e-06 | 50 |
| GO:00714267 | Thyroid | PTC | ribonucleoprotein complex export from nucleus | 46/5968 | 76/18723 | 2.48e-07 | 4.32e-06 | 46 |
| GO:00064066 | Thyroid | PTC | mRNA export from nucleus | 34/5968 | 59/18723 | 3.88e-05 | 3.57e-04 | 34 |
| GO:00714276 | Thyroid | PTC | mRNA-containing ribonucleoprotein complex export from nucleus | 34/5968 | 59/18723 | 3.88e-05 | 3.57e-04 | 34 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FYTTD1 | SNV | Missense_Mutation | c.125N>A | p.Arg42Gln | p.R42Q | Q96QD9 | protein_coding | deleterious(0.05) | benign(0.207) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| FYTTD1 | SNV | Missense_Mutation | c.218N>A | p.Gly73Glu | p.G73E | Q96QD9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| FYTTD1 | SNV | Missense_Mutation | c.187N>A | p.Ala63Thr | p.A63T | Q96QD9 | protein_coding | tolerated(0.63) | benign(0.007) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FYTTD1 | SNV | Missense_Mutation | rs779562426 | c.746N>A | p.Arg249Gln | p.R249Q | Q96QD9 | protein_coding | tolerated(0.12) | probably_damaging(0.992) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| FYTTD1 | SNV | Missense_Mutation | c.880N>T | p.Arg294Trp | p.R294W | Q96QD9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FYTTD1 | SNV | Missense_Mutation | c.228N>T | p.Gln76His | p.Q76H | Q96QD9 | protein_coding | deleterious(0.01) | possibly_damaging(0.9) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
| FYTTD1 | SNV | Missense_Mutation | novel | c.586N>T | p.Gly196Cys | p.G196C | Q96QD9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| FYTTD1 | SNV | Missense_Mutation | c.125G>A | p.Arg42Gln | p.R42Q | Q96QD9 | protein_coding | deleterious(0.05) | benign(0.207) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
| FYTTD1 | SNV | Missense_Mutation | c.285G>T | p.Lys95Asn | p.K95N | Q96QD9 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
| FYTTD1 | SNV | Missense_Mutation | c.647N>T | p.Arg216Ile | p.R216I | Q96QD9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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