Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: FSD2

Gene summary for FSD2

Gene summary.

Gene information	Species	Human
	Gene symbol	FSD2
	Gene ID	123722
	Gene name	fibronectin type III and SPRY domain containing 2
	Gene Alias	SPRYD1
	Cytomap	15q25.2
	Gene Type	protein-coding
	GO ID	GO:0005575
	UniProtAcc	A1L4K1

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
123722	FSD2	HCC1	Human	Liver	HCC	6.31e-22	1.60e+00	0.5336
123722	FSD2	HCC2	Human	Liver	HCC	6.04e-30	2.02e+00	0.5341
123722	FSD2	HCC5	Human	Liver	HCC	4.49e-23	1.51e+00	0.4932

Page: 1

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Liver		HCC: Hepatocellular carcinoma
Liver		NAFLD: Non-alcoholic fatty liver disease

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:003166825	Skin	cSCC	cellular response to extracellular stimulus	94/4864	246/18723	1.52e-05	1.87e-04	94
GO:000926722	Skin	cSCC	cellular response to starvation	64/4864	156/18723	2.79e-05	3.12e-04	64
GO:0042594110	Skin	cSCC	response to starvation	77/4864	197/18723	3.52e-05	3.82e-04	77
GO:00065758	Skin	cSCC	cellular modified amino acid metabolic process	73/4864	188/18723	7.11e-05	6.85e-04	73
GO:003166728	Skin	cSCC	response to nutrient levels	160/4864	474/18723	8.44e-05	8.02e-04	160
GO:003166925	Skin	cSCC	cellular response to nutrient levels	80/4864	215/18723	1.76e-04	1.50e-03	80
GO:000155824	Skin	cSCC	regulation of cell growth	140/4864	414/18723	2.07e-04	1.72e-03	140
GO:003030722	Skin	cSCC	positive regulation of cell growth	61/4864	166/18723	1.39e-03	8.78e-03	61
GO:002154311	Skin	cSCC	pallium development	61/4864	169/18723	2.27e-03	1.33e-02	61
GO:00450569	Skin	cSCC	transcytosis	12/4864	21/18723	2.40e-03	1.38e-02	12
GO:001097522	Skin	cSCC	regulation of neuron projection development	141/4864	445/18723	3.72e-03	1.99e-02	141
GO:00066359	Skin	cSCC	fatty acid beta-oxidation	30/4864	74/18723	4.32e-03	2.27e-02	30
GO:004592719	Skin	cSCC	positive regulation of growth	85/4864	259/18723	8.03e-03	3.73e-02	85
GO:0022604112	Thyroid	PTC	regulation of cell morphogenesis	165/5968	309/18723	2.60e-15	1.82e-13	165
GO:0016049112	Thyroid	PTC	cell growth	225/5968	482/18723	4.75e-12	2.07e-10	225
GO:0071496113	Thyroid	PTC	cellular response to external stimulus	158/5968	320/18723	4.12e-11	1.47e-09	158
GO:0031330113	Thyroid	PTC	negative regulation of cellular catabolic process	131/5968	262/18723	6.63e-10	2.03e-08	131
GO:0009895113	Thyroid	PTC	negative regulation of catabolic process	154/5968	320/18723	7.77e-10	2.31e-08	154
GO:0001558111	Thyroid	PTC	regulation of cell growth	188/5968	414/18723	4.13e-09	1.09e-07	188
GO:0031668113	Thyroid	PTC	cellular response to extracellular stimulus	120/5968	246/18723	2.13e-08	4.91e-07	120

Page: 1 2 3 4 5 6 7 8 9

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

FSD2

SNV

Missense_Mutation

rs200109394

c.1411N>T

p.Pro471Ser

p.P471S

A1L4K1

protein_coding

deleterious(0.04)

probably_damaging(1)

TCGA-A7-A26E-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Chemotherapy

cytoxan

FSD2

SNV

Missense_Mutation

c.413N>T

p.Gly138Val

p.G138V

A1L4K1

protein_coding

deleterious(0.04)

benign(0.348)

TCGA-AN-A0AM-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

FSD2

SNV

Missense_Mutation

rs774888742

c.1499N>T

p.Ser500Leu

p.S500L

A1L4K1

protein_coding

deleterious(0)

probably_damaging(0.998)

TCGA-D8-A142-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

cyclophosphamid

FSD2

SNV

Missense_Mutation

c.923C>A

p.Thr308Lys

p.T308K

A1L4K1

protein_coding

deleterious(0.01)

benign(0.435)

TCGA-D8-A1X9-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

adriamycin+cyclophosphamide

FSD2

SNV

Missense_Mutation

rs781225191

c.388G>A

p.Glu130Lys

p.E130K

A1L4K1

protein_coding

tolerated(0.07)

benign(0.096)

TCGA-DS-A0VK-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

carboplatin

FSD2

SNV

Missense_Mutation

novel

c.493N>T

p.Val165Phe

p.V165F

A1L4K1

protein_coding

deleterious(0)

probably_damaging(0.957)

TCGA-DS-A1OC-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

gemcitabine

FSD2

SNV

Missense_Mutation

c.520N>A

p.Glu174Lys

p.E174K

A1L4K1

protein_coding

tolerated(0.07)

possibly_damaging(0.867)

TCGA-JW-A5VL-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

FSD2

SNV

Missense_Mutation

c.1398G>A

p.Met466Ile

p.M466I

A1L4K1

protein_coding

tolerated(0.05)

benign(0.003)

TCGA-LP-A4AV-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

FSD2

SNV

Missense_Mutation

c.88G>A

p.Glu30Lys

p.E30K

A1L4K1

protein_coding

tolerated(0.41)

benign(0.006)

TCGA-VS-A8QC-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

paclitaxel

FSD2

SNV

Missense_Mutation

novel

c.586N>A

p.Glu196Lys

p.E196K

A1L4K1

protein_coding

deleterious(0.04)

benign(0.157)

TCGA-ZJ-AAXU-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

Page: 1 2 3 4 5 6 7 8 9

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1