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Gene: FOXK2 |
Gene summary for FOXK2 |
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Gene information | Species | Human | Gene symbol | FOXK2 | Gene ID | 3607 |
Gene name | forkhead box K2 | |
Gene Alias | ILF | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q01167 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3607 | FOXK2 | CCI_1 | Human | Cervix | CC | 2.74e-07 | 7.44e-01 | 0.528 |
3607 | FOXK2 | CCI_2 | Human | Cervix | CC | 5.96e-14 | 1.13e+00 | 0.5249 |
3607 | FOXK2 | CCI_3 | Human | Cervix | CC | 6.95e-14 | 8.66e-01 | 0.516 |
3607 | FOXK2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.56e-05 | -3.67e-01 | 0.0155 |
3607 | FOXK2 | F007 | Human | Colorectum | FAP | 5.81e-05 | -3.73e-01 | 0.1176 |
3607 | FOXK2 | A002-C-010 | Human | Colorectum | FAP | 4.50e-04 | -2.50e-01 | 0.242 |
3607 | FOXK2 | A001-C-207 | Human | Colorectum | FAP | 1.30e-05 | -3.17e-01 | 0.1278 |
3607 | FOXK2 | A015-C-203 | Human | Colorectum | FAP | 3.64e-30 | -3.89e-01 | -0.1294 |
3607 | FOXK2 | A015-C-204 | Human | Colorectum | FAP | 6.57e-09 | -3.86e-01 | -0.0228 |
3607 | FOXK2 | A014-C-040 | Human | Colorectum | FAP | 3.08e-06 | -5.23e-01 | -0.1184 |
3607 | FOXK2 | A002-C-201 | Human | Colorectum | FAP | 7.00e-18 | -2.77e-01 | 0.0324 |
3607 | FOXK2 | A002-C-203 | Human | Colorectum | FAP | 9.70e-09 | -2.88e-01 | 0.2786 |
3607 | FOXK2 | A001-C-119 | Human | Colorectum | FAP | 1.71e-04 | -2.16e-01 | -0.1557 |
3607 | FOXK2 | A001-C-108 | Human | Colorectum | FAP | 4.56e-18 | -2.23e-01 | -0.0272 |
3607 | FOXK2 | A002-C-205 | Human | Colorectum | FAP | 4.06e-24 | -4.04e-01 | -0.1236 |
3607 | FOXK2 | A001-C-104 | Human | Colorectum | FAP | 2.20e-07 | -1.78e-01 | 0.0184 |
3607 | FOXK2 | A015-C-005 | Human | Colorectum | FAP | 1.94e-06 | -3.05e-01 | -0.0336 |
3607 | FOXK2 | A015-C-006 | Human | Colorectum | FAP | 3.08e-17 | -3.49e-01 | -0.0994 |
3607 | FOXK2 | A015-C-106 | Human | Colorectum | FAP | 2.59e-12 | -2.40e-01 | -0.0511 |
3607 | FOXK2 | A002-C-114 | Human | Colorectum | FAP | 2.67e-20 | -3.59e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00105072 | Colorectum | FAP | negative regulation of autophagy | 24/2622 | 85/18723 | 4.59e-04 | 5.39e-03 | 24 |
GO:0006007 | Colorectum | FAP | glucose catabolic process | 9/2622 | 19/18723 | 4.99e-04 | 5.72e-03 | 9 |
GO:0046365 | Colorectum | FAP | monosaccharide catabolic process | 14/2622 | 40/18723 | 6.94e-04 | 7.50e-03 | 14 |
GO:0010675 | Colorectum | FAP | regulation of cellular carbohydrate metabolic process | 35/2622 | 146/18723 | 8.41e-04 | 8.72e-03 | 35 |
GO:00067351 | Colorectum | FAP | NADH regeneration | 6/2622 | 10/18723 | 9.48e-04 | 9.39e-03 | 6 |
GO:00616211 | Colorectum | FAP | canonical glycolysis | 6/2622 | 10/18723 | 9.48e-04 | 9.39e-03 | 6 |
GO:00617181 | Colorectum | FAP | glucose catabolic process to pyruvate | 6/2622 | 10/18723 | 9.48e-04 | 9.39e-03 | 6 |
GO:00067343 | Colorectum | FAP | NADH metabolic process | 11/2622 | 29/18723 | 1.20e-03 | 1.14e-02 | 11 |
GO:00196741 | Colorectum | FAP | NAD metabolic process | 11/2622 | 30/18723 | 1.66e-03 | 1.46e-02 | 11 |
GO:0061620 | Colorectum | FAP | glycolytic process through glucose-6-phosphate | 6/2622 | 12/18723 | 3.24e-03 | 2.40e-02 | 6 |
GO:0061615 | Colorectum | FAP | glycolytic process through fructose-6-phosphate | 6/2622 | 13/18723 | 5.32e-03 | 3.49e-02 | 6 |
GO:0010906 | Colorectum | FAP | regulation of glucose metabolic process | 27/2622 | 119/18723 | 6.87e-03 | 4.22e-02 | 27 |
GO:00098955 | Colorectum | CRC | negative regulation of catabolic process | 75/2078 | 320/18723 | 2.02e-10 | 9.31e-08 | 75 |
GO:00313305 | Colorectum | CRC | negative regulation of cellular catabolic process | 61/2078 | 262/18723 | 1.27e-08 | 2.54e-06 | 61 |
GO:00460315 | Colorectum | CRC | ADP metabolic process | 28/2078 | 90/18723 | 2.43e-07 | 2.27e-05 | 28 |
GO:00091505 | Colorectum | CRC | purine ribonucleotide metabolic process | 74/2078 | 368/18723 | 2.58e-07 | 2.38e-05 | 74 |
GO:00061635 | Colorectum | CRC | purine nucleotide metabolic process | 78/2078 | 396/18723 | 2.98e-07 | 2.59e-05 | 78 |
GO:00060965 | Colorectum | CRC | glycolytic process | 26/2078 | 81/18723 | 3.26e-07 | 2.79e-05 | 26 |
GO:00067575 | Colorectum | CRC | ATP generation from ADP | 26/2078 | 82/18723 | 4.27e-07 | 3.37e-05 | 26 |
GO:00091355 | Colorectum | CRC | purine nucleoside diphosphate metabolic process | 30/2078 | 103/18723 | 4.56e-07 | 3.39e-05 | 30 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXK2 | SNV | Missense_Mutation | c.617N>T | p.Ala206Val | p.A206V | Q01167 | protein_coding | tolerated(0.43) | benign(0.021) | TCGA-AR-A24N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FOXK2 | deletion | Frame_Shift_Del | novel | c.1194delG | p.Pro399ArgfsTer38 | p.P399Rfs*38 | Q01167 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FOXK2 | SNV | Missense_Mutation | rs773115793 | c.1321N>T | p.Arg441Trp | p.R441W | Q01167 | protein_coding | tolerated(0.05) | probably_damaging(0.952) | TCGA-JW-A852-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
FOXK2 | SNV | Missense_Mutation | c.1037N>A | p.Ala346Asp | p.A346D | Q01167 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
FOXK2 | SNV | Missense_Mutation | c.940C>T | p.Arg314Cys | p.R314C | Q01167 | protein_coding | deleterious(0.04) | possibly_damaging(0.702) | TCGA-AA-3860-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR | |
FOXK2 | SNV | Missense_Mutation | novel | c.584G>A | p.Ser195Asn | p.S195N | Q01167 | protein_coding | deleterious(0.01) | benign(0.298) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FOXK2 | SNV | Missense_Mutation | c.1091C>T | p.Pro364Leu | p.P364L | Q01167 | protein_coding | tolerated(0.06) | possibly_damaging(0.846) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FOXK2 | SNV | Missense_Mutation | novel | c.1225N>A | p.Ala409Thr | p.A409T | Q01167 | protein_coding | tolerated(0.28) | benign(0.028) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXK2 | SNV | Missense_Mutation | rs766532897 | c.1790N>T | p.Ala597Val | p.A597V | Q01167 | protein_coding | tolerated(1) | benign(0.009) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXK2 | SNV | Missense_Mutation | rs139388643 | c.961C>T | p.Arg321Cys | p.R321C | Q01167 | protein_coding | deleterious(0.04) | possibly_damaging(0.839) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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