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Gene: FBXO7 |
Gene summary for FBXO7 |
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Gene information | Species | Human | Gene symbol | FBXO7 | Gene ID | 25793 |
Gene name | F-box protein 7 | |
Gene Alias | FBX | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000079 | UniProtAcc | Q9Y3I1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25793 | FBXO7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.59e-05 | 4.91e-01 | -0.0811 |
25793 | FBXO7 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.22e-06 | 3.35e-01 | -0.1954 |
25793 | FBXO7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.43e-08 | 4.83e-01 | -0.059 |
25793 | FBXO7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.08e-03 | 2.33e-01 | 0.0674 |
25793 | FBXO7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.33e-12 | 4.99e-01 | 0.294 |
25793 | FBXO7 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.24e-02 | 8.03e-01 | 0.3487 |
25793 | FBXO7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.95e-11 | 5.32e-01 | 0.3859 |
25793 | FBXO7 | A015-C-203 | Human | Colorectum | FAP | 1.40e-05 | -1.19e-01 | -0.1294 |
25793 | FBXO7 | A001-C-108 | Human | Colorectum | FAP | 2.98e-02 | -1.07e-01 | -0.0272 |
25793 | FBXO7 | A002-C-205 | Human | Colorectum | FAP | 6.28e-03 | -1.40e-01 | -0.1236 |
25793 | FBXO7 | A002-C-114 | Human | Colorectum | FAP | 8.55e-03 | -1.84e-01 | -0.1561 |
25793 | FBXO7 | A015-C-104 | Human | Colorectum | FAP | 2.30e-04 | -8.95e-02 | -0.1899 |
25793 | FBXO7 | A002-C-116 | Human | Colorectum | FAP | 6.96e-05 | -8.61e-02 | -0.0452 |
25793 | FBXO7 | F034 | Human | Colorectum | FAP | 1.35e-02 | -7.51e-02 | -0.0665 |
25793 | FBXO7 | LZE4T | Human | Esophagus | ESCC | 1.29e-18 | 3.11e-01 | 0.0811 |
25793 | FBXO7 | LZE5T | Human | Esophagus | ESCC | 2.51e-05 | 2.05e-01 | 0.0514 |
25793 | FBXO7 | LZE7T | Human | Esophagus | ESCC | 4.73e-10 | 7.54e-01 | 0.0667 |
25793 | FBXO7 | LZE8T | Human | Esophagus | ESCC | 5.66e-12 | 2.17e-01 | 0.067 |
25793 | FBXO7 | LZE22T | Human | Esophagus | ESCC | 3.46e-02 | 3.49e-01 | 0.068 |
25793 | FBXO7 | LZE24T | Human | Esophagus | ESCC | 1.29e-26 | 9.28e-01 | 0.0596 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00726553 | Colorectum | MSI-H | establishment of protein localization to mitochondrion | 21/1319 | 120/18723 | 9.12e-05 | 2.93e-03 | 21 |
GO:00459363 | Colorectum | MSI-H | negative regulation of phosphate metabolic process | 53/1319 | 441/18723 | 9.54e-05 | 3.01e-03 | 53 |
GO:00105633 | Colorectum | MSI-H | negative regulation of phosphorus metabolic process | 53/1319 | 442/18723 | 1.01e-04 | 3.16e-03 | 53 |
GO:19032043 | Colorectum | MSI-H | negative regulation of oxidative stress-induced neuron death | 7/1319 | 19/18723 | 2.01e-04 | 5.31e-03 | 7 |
GO:19032021 | Colorectum | MSI-H | negative regulation of oxidative stress-induced cell death | 12/1319 | 53/18723 | 2.53e-04 | 6.54e-03 | 12 |
GO:19031463 | Colorectum | MSI-H | regulation of autophagy of mitochondrion | 9/1319 | 33/18723 | 3.41e-04 | 8.03e-03 | 9 |
GO:19032033 | Colorectum | MSI-H | regulation of oxidative stress-induced neuron death | 8/1319 | 27/18723 | 3.93e-04 | 8.91e-03 | 8 |
GO:00068393 | Colorectum | MSI-H | mitochondrial transport | 33/1319 | 254/18723 | 4.87e-04 | 1.02e-02 | 33 |
GO:00423263 | Colorectum | MSI-H | negative regulation of phosphorylation | 45/1319 | 385/18723 | 5.71e-04 | 1.14e-02 | 45 |
GO:00066263 | Colorectum | MSI-H | protein targeting to mitochondrion | 17/1319 | 100/18723 | 5.84e-04 | 1.16e-02 | 17 |
GO:19035993 | Colorectum | MSI-H | positive regulation of autophagy of mitochondrion | 5/1319 | 12/18723 | 8.97e-04 | 1.58e-02 | 5 |
GO:00364753 | Colorectum | MSI-H | neuron death in response to oxidative stress | 8/1319 | 31/18723 | 1.08e-03 | 1.84e-02 | 8 |
GO:00019333 | Colorectum | MSI-H | negative regulation of protein phosphorylation | 40/1319 | 342/18723 | 1.11e-03 | 1.86e-02 | 40 |
GO:00709973 | Colorectum | MSI-H | neuron death | 41/1319 | 361/18723 | 1.70e-03 | 2.48e-02 | 41 |
GO:19012143 | Colorectum | MSI-H | regulation of neuron death | 37/1319 | 319/18723 | 1.93e-03 | 2.76e-02 | 37 |
GO:19037062 | Colorectum | MSI-H | regulation of hemopoiesis | 41/1319 | 367/18723 | 2.31e-03 | 3.09e-02 | 41 |
GO:00224113 | Colorectum | MSI-H | cellular component disassembly | 47/1319 | 443/18723 | 3.26e-03 | 3.99e-02 | 47 |
GO:00004223 | Colorectum | MSI-H | autophagy of mitochondrion | 13/1319 | 81/18723 | 4.17e-03 | 4.73e-02 | 13 |
GO:00617263 | Colorectum | MSI-H | mitochondrion disassembly | 13/1319 | 81/18723 | 4.17e-03 | 4.73e-02 | 13 |
GO:00098964 | Colorectum | FAP | positive regulation of catabolic process | 126/2622 | 492/18723 | 3.76e-12 | 2.56e-09 | 126 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXO7 | SNV | Missense_Mutation | c.1042N>T | p.Asp348Tyr | p.D348Y | Q9Y3I1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A24T-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
FBXO7 | SNV | Missense_Mutation | novel | c.1171N>C | p.Asp391His | p.D391H | Q9Y3I1 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
FBXO7 | SNV | Missense_Mutation | c.997N>C | p.Val333Leu | p.V333L | Q9Y3I1 | protein_coding | tolerated(0.37) | benign(0.007) | TCGA-D8-A1XR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
FBXO7 | insertion | Frame_Shift_Ins | novel | c.616_617insAAAATTT | p.Leu206GlnfsTer32 | p.L206Qfs*32 | Q9Y3I1 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FBXO7 | SNV | Missense_Mutation | c.823N>C | p.Lys275Gln | p.K275Q | Q9Y3I1 | protein_coding | tolerated(0.12) | possibly_damaging(0.795) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBXO7 | SNV | Missense_Mutation | rs376214763 | c.652G>A | p.Glu218Lys | p.E218K | Q9Y3I1 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO7 | SNV | Missense_Mutation | c.713N>T | p.Tyr238Phe | p.Y238F | Q9Y3I1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FBXO7 | SNV | Missense_Mutation | c.848N>A | p.Ser283Tyr | p.S283Y | Q9Y3I1 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FBXO7 | SNV | Missense_Mutation | rs376455464 | c.521N>T | p.Ser174Leu | p.S174L | Q9Y3I1 | protein_coding | deleterious(0) | benign(0.058) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FBXO7 | SNV | Missense_Mutation | c.1118N>A | p.Arg373Lys | p.R373K | Q9Y3I1 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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