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Gene: DPYSL3 |
Gene summary for DPYSL3 |
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Gene information | Species | Human | Gene symbol | DPYSL3 | Gene ID | 1809 |
Gene name | dihydropyrimidinase like 3 | |
Gene Alias | CRMP-4 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | A0A140VK07 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1809 | DPYSL3 | LZE4T | Human | Esophagus | ESCC | 5.03e-06 | 2.24e-01 | 0.0811 |
1809 | DPYSL3 | LZE7T | Human | Esophagus | ESCC | 1.86e-09 | 8.30e-01 | 0.0667 |
1809 | DPYSL3 | LZE8T | Human | Esophagus | ESCC | 7.46e-10 | 4.58e-01 | 0.067 |
1809 | DPYSL3 | LZE24T | Human | Esophagus | ESCC | 1.26e-04 | 2.01e-01 | 0.0596 |
1809 | DPYSL3 | LZE21T | Human | Esophagus | ESCC | 1.68e-05 | 5.91e-01 | 0.0655 |
1809 | DPYSL3 | P2T-E | Human | Esophagus | ESCC | 1.74e-05 | 2.81e-01 | 0.1177 |
1809 | DPYSL3 | P4T-E | Human | Esophagus | ESCC | 1.16e-15 | 6.17e-01 | 0.1323 |
1809 | DPYSL3 | P5T-E | Human | Esophagus | ESCC | 1.57e-22 | 4.78e-01 | 0.1327 |
1809 | DPYSL3 | P8T-E | Human | Esophagus | ESCC | 5.85e-35 | 6.64e-01 | 0.0889 |
1809 | DPYSL3 | P9T-E | Human | Esophagus | ESCC | 1.01e-33 | 8.43e-01 | 0.1131 |
1809 | DPYSL3 | P10T-E | Human | Esophagus | ESCC | 5.33e-21 | 4.92e-01 | 0.116 |
1809 | DPYSL3 | P11T-E | Human | Esophagus | ESCC | 2.81e-28 | 1.21e+00 | 0.1426 |
1809 | DPYSL3 | P12T-E | Human | Esophagus | ESCC | 1.80e-43 | 1.05e+00 | 0.1122 |
1809 | DPYSL3 | P15T-E | Human | Esophagus | ESCC | 8.89e-34 | 9.03e-01 | 0.1149 |
1809 | DPYSL3 | P16T-E | Human | Esophagus | ESCC | 6.79e-12 | 5.16e-02 | 0.1153 |
1809 | DPYSL3 | P19T-E | Human | Esophagus | ESCC | 1.63e-13 | 1.26e+00 | 0.1662 |
1809 | DPYSL3 | P21T-E | Human | Esophagus | ESCC | 1.58e-35 | 7.25e-01 | 0.1617 |
1809 | DPYSL3 | P22T-E | Human | Esophagus | ESCC | 1.35e-02 | 1.42e-01 | 0.1236 |
1809 | DPYSL3 | P23T-E | Human | Esophagus | ESCC | 2.95e-43 | 1.19e+00 | 0.108 |
1809 | DPYSL3 | P24T-E | Human | Esophagus | ESCC | 1.32e-09 | 4.26e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00468472 | Thyroid | ATC | filopodium assembly | 34/6293 | 62/18723 | 4.66e-04 | 2.74e-03 | 34 |
GO:004001316 | Thyroid | ATC | negative regulation of locomotion | 160/6293 | 391/18723 | 1.36e-03 | 7.07e-03 | 160 |
GO:003033616 | Thyroid | ATC | negative regulation of cell migration | 142/6293 | 344/18723 | 1.64e-03 | 8.22e-03 | 142 |
GO:005127117 | Thyroid | ATC | negative regulation of cellular component movement | 150/6293 | 367/18723 | 1.99e-03 | 9.54e-03 | 150 |
GO:200014617 | Thyroid | ATC | negative regulation of cell motility | 147/6293 | 359/18723 | 2.01e-03 | 9.60e-03 | 147 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPYSL3 | SNV | Missense_Mutation | c.1470N>A | p.Asp490Glu | p.D490E | Q14195 | protein_coding | deleterious(0) | possibly_damaging(0.815) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
DPYSL3 | SNV | Missense_Mutation | rs750296589 | c.545N>A | p.Gly182Glu | p.G182E | Q14195 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DPYSL3 | SNV | Missense_Mutation | c.760N>C | p.Asp254His | p.D254H | Q14195 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-BH-A0B7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
DPYSL3 | SNV | Missense_Mutation | rs754356799 | c.1471N>A | p.Glu491Lys | p.E491K | Q14195 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-BH-A5J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DPYSL3 | SNV | Missense_Mutation | c.1423N>T | p.Arg475Trp | p.R475W | Q14195 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DPYSL3 | SNV | Missense_Mutation | c.1036N>A | p.Glu346Lys | p.E346K | Q14195 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
DPYSL3 | SNV | Missense_Mutation | c.424N>A | p.Asp142Asn | p.D142N | Q14195 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
DPYSL3 | SNV | Missense_Mutation | rs757343684 | c.1570G>A | p.Val524Ile | p.V524I | Q14195 | protein_coding | deleterious(0.04) | benign(0.212) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DPYSL3 | SNV | Missense_Mutation | c.732G>C | p.Lys244Asn | p.K244N | Q14195 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
DPYSL3 | SNV | Missense_Mutation | rs751361322 | c.1900C>T | p.Arg634Trp | p.R634W | Q14195 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1809 | DPYSL3 | NA | METHIMAZOLE | METHIMAZOLE | 11694350 |
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