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Gene: CUL5 |
Gene summary for CUL5 |
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Gene information | Species | Human | Gene symbol | CUL5 | Gene ID | 8065 |
Gene name | cullin 5 | |
Gene Alias | CUL-5 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q93034 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8065 | CUL5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.00e-07 | -4.93e-01 | 0.0155 |
8065 | CUL5 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.92e-02 | -3.79e-01 | 0.096 |
8065 | CUL5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.69e-05 | -3.10e-01 | 0.294 |
8065 | CUL5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.16e-05 | -3.48e-01 | 0.3005 |
8065 | CUL5 | A015-C-203 | Human | Colorectum | FAP | 6.83e-22 | -2.87e-01 | -0.1294 |
8065 | CUL5 | A002-C-201 | Human | Colorectum | FAP | 3.97e-09 | -4.00e-01 | 0.0324 |
8065 | CUL5 | A001-C-119 | Human | Colorectum | FAP | 7.23e-03 | -3.48e-01 | -0.1557 |
8065 | CUL5 | A001-C-108 | Human | Colorectum | FAP | 2.34e-14 | -3.14e-01 | -0.0272 |
8065 | CUL5 | A002-C-205 | Human | Colorectum | FAP | 2.82e-12 | -3.85e-01 | -0.1236 |
8065 | CUL5 | A015-C-006 | Human | Colorectum | FAP | 5.78e-10 | -4.90e-01 | -0.0994 |
8065 | CUL5 | A015-C-106 | Human | Colorectum | FAP | 7.01e-09 | -2.29e-01 | -0.0511 |
8065 | CUL5 | A002-C-114 | Human | Colorectum | FAP | 1.01e-08 | -1.99e-01 | -0.1561 |
8065 | CUL5 | A015-C-104 | Human | Colorectum | FAP | 5.64e-23 | -3.68e-01 | -0.1899 |
8065 | CUL5 | A001-C-014 | Human | Colorectum | FAP | 7.81e-10 | -3.07e-01 | 0.0135 |
8065 | CUL5 | A002-C-016 | Human | Colorectum | FAP | 1.67e-16 | -3.67e-01 | 0.0521 |
8065 | CUL5 | A015-C-002 | Human | Colorectum | FAP | 2.60e-07 | -3.96e-01 | -0.0763 |
8065 | CUL5 | A001-C-203 | Human | Colorectum | FAP | 1.61e-07 | -1.96e-01 | -0.0481 |
8065 | CUL5 | A002-C-116 | Human | Colorectum | FAP | 4.51e-23 | -3.90e-01 | -0.0452 |
8065 | CUL5 | A014-C-008 | Human | Colorectum | FAP | 2.27e-07 | -3.77e-01 | -0.191 |
8065 | CUL5 | A018-E-020 | Human | Colorectum | FAP | 3.58e-12 | -4.21e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004477218 | Thyroid | PTC | mitotic cell cycle phase transition | 196/5968 | 424/18723 | 3.17e-10 | 1.02e-08 | 196 |
GO:003812720 | Thyroid | PTC | ERBB signaling pathway | 66/5968 | 121/18723 | 1.97e-07 | 3.54e-06 | 66 |
GO:00000829 | Thyroid | PTC | G1/S transition of mitotic cell cycle | 102/5968 | 214/18723 | 9.48e-07 | 1.43e-05 | 102 |
GO:00448439 | Thyroid | PTC | cell cycle G1/S phase transition | 112/5968 | 241/18723 | 1.37e-06 | 1.96e-05 | 112 |
GO:001049832 | Thyroid | ATC | proteasomal protein catabolic process | 309/6293 | 490/18723 | 1.78e-41 | 1.13e-37 | 309 |
GO:0043161210 | Thyroid | ATC | proteasome-mediated ubiquitin-dependent protein catabolic process | 265/6293 | 412/18723 | 7.09e-38 | 1.49e-34 | 265 |
GO:009719335 | Thyroid | ATC | intrinsic apoptotic signaling pathway | 171/6293 | 288/18723 | 1.86e-19 | 2.67e-17 | 171 |
GO:004477219 | Thyroid | ATC | mitotic cell cycle phase transition | 223/6293 | 424/18723 | 3.46e-16 | 2.88e-14 | 223 |
GO:0038127111 | Thyroid | ATC | ERBB signaling pathway | 71/6293 | 121/18723 | 1.31e-08 | 2.69e-07 | 71 |
GO:004484316 | Thyroid | ATC | cell cycle G1/S phase transition | 119/6293 | 241/18723 | 2.68e-07 | 4.10e-06 | 119 |
GO:000008216 | Thyroid | ATC | G1/S transition of mitotic cell cycle | 107/6293 | 214/18723 | 4.83e-07 | 6.99e-06 | 107 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa041204 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa051704 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa041205 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa051705 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa041206 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa051706 | Colorectum | FAP | Human immunodeficiency virus 1 infection | 51/1404 | 212/8465 | 2.98e-03 | 1.29e-02 | 7.87e-03 | 51 |
hsa041207 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa051707 | Colorectum | FAP | Human immunodeficiency virus 1 infection | 51/1404 | 212/8465 | 2.98e-03 | 1.29e-02 | 7.87e-03 | 51 |
hsa041208 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa041209 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0412010 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412011 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CUL5 | SNV | Missense_Mutation | rs754810606 | c.1091N>A | p.Arg364Gln | p.R364Q | Q93034 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CUL5 | SNV | Missense_Mutation | c.1960G>A | p.Val654Ile | p.V654I | Q93034 | protein_coding | tolerated(0.21) | benign(0.013) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CUL5 | SNV | Missense_Mutation | c.760N>C | p.Glu254Gln | p.E254Q | Q93034 | protein_coding | tolerated(0.39) | benign(0.05) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
CUL5 | SNV | Missense_Mutation | c.2256N>C | p.Met752Ile | p.M752I | Q93034 | protein_coding | tolerated(0.1) | benign(0.098) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
CUL5 | SNV | Missense_Mutation | rs754810606 | c.1091N>A | p.Arg364Gln | p.R364Q | Q93034 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CUL5 | SNV | Missense_Mutation | c.1967C>T | p.Ser656Leu | p.S656L | Q93034 | protein_coding | deleterious(0) | possibly_damaging(0.703) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
CUL5 | SNV | Missense_Mutation | c.1534N>A | p.Glu512Lys | p.E512K | Q93034 | protein_coding | tolerated(0.37) | benign(0.017) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CUL5 | SNV | Missense_Mutation | novel | c.852N>A | p.Met284Ile | p.M284I | Q93034 | protein_coding | deleterious(0.02) | benign(0.041) | TCGA-VS-A9V5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
CUL5 | SNV | Missense_Mutation | c.232G>A | p.Ala78Thr | p.A78T | Q93034 | protein_coding | tolerated(0.47) | benign(0.001) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CUL5 | SNV | Missense_Mutation | c.134N>T | p.Ser45Leu | p.S45L | Q93034 | protein_coding | tolerated(0.63) | benign(0.023) | TCGA-AA-3675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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