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Gene: CSNK2B |
Gene summary for CSNK2B |
Gene summary. |
Gene information | Species | Human | Gene symbol | CSNK2B | Gene ID | 1460 |
Gene name | casein kinase 2 beta | |
Gene Alias | CK2B | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | A0A1U9X7J2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1460 | CSNK2B | CA_HPV_1 | Human | Cervix | CC | 2.11e-03 | -1.68e-01 | 0.0264 |
1460 | CSNK2B | N_HPV_2 | Human | Cervix | N_HPV | 7.03e-03 | 1.12e-01 | -0.0131 |
1460 | CSNK2B | CCI_1 | Human | Cervix | CC | 8.24e-06 | -5.08e-01 | 0.528 |
1460 | CSNK2B | CCI_2 | Human | Cervix | CC | 3.20e-05 | -5.08e-01 | 0.5249 |
1460 | CSNK2B | CCI_3 | Human | Cervix | CC | 3.50e-08 | -5.08e-01 | 0.516 |
1460 | CSNK2B | CCII_1 | Human | Cervix | CC | 8.11e-12 | -5.08e-01 | 0.3249 |
1460 | CSNK2B | sample3 | Human | Cervix | CC | 5.58e-07 | 1.96e-01 | 0.1387 |
1460 | CSNK2B | T3 | Human | Cervix | CC | 2.74e-07 | 2.19e-01 | 0.1389 |
1460 | CSNK2B | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.63e-18 | 3.46e-01 | 0.0155 |
1460 | CSNK2B | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.75e-24 | 5.54e-01 | -0.1808 |
1460 | CSNK2B | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.03e-06 | 3.36e-01 | 0.0216 |
1460 | CSNK2B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.05e-20 | 6.33e-01 | -0.0811 |
1460 | CSNK2B | HTA11_78_2000001011 | Human | Colorectum | AD | 3.40e-20 | 4.49e-01 | -0.1088 |
1460 | CSNK2B | HTA11_347_2000001011 | Human | Colorectum | AD | 5.03e-52 | 7.85e-01 | -0.1954 |
1460 | CSNK2B | HTA11_411_2000001011 | Human | Colorectum | SER | 6.42e-18 | 9.53e-01 | -0.2602 |
1460 | CSNK2B | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.75e-12 | 7.74e-01 | -0.2196 |
1460 | CSNK2B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.74e-18 | 5.72e-01 | -0.1207 |
1460 | CSNK2B | HTA11_83_2000001011 | Human | Colorectum | SER | 4.15e-23 | 5.85e-01 | -0.1526 |
1460 | CSNK2B | HTA11_696_2000001011 | Human | Colorectum | AD | 2.49e-45 | 7.53e-01 | -0.1464 |
1460 | CSNK2B | HTA11_866_2000001011 | Human | Colorectum | AD | 9.10e-25 | 4.62e-01 | -0.1001 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00901301 | Colorectum | SER | tissue migration | 82/2897 | 365/18723 | 2.40e-04 | 4.12e-03 | 82 |
GO:00106321 | Colorectum | SER | regulation of epithelial cell migration | 68/2897 | 292/18723 | 2.72e-04 | 4.53e-03 | 68 |
GO:00511011 | Colorectum | SER | regulation of DNA binding | 33/2897 | 118/18723 | 3.70e-04 | 5.71e-03 | 33 |
GO:00974211 | Colorectum | SER | liver regeneration | 14/2897 | 35/18723 | 4.02e-04 | 6.02e-03 | 14 |
GO:00064701 | Colorectum | SER | protein dephosphorylation | 65/2897 | 281/18723 | 4.44e-04 | 6.51e-03 | 65 |
GO:00109211 | Colorectum | SER | regulation of phosphatase activity | 24/2897 | 84/18723 | 1.61e-03 | 1.71e-02 | 24 |
GO:00353031 | Colorectum | SER | regulation of dephosphorylation | 33/2897 | 128/18723 | 1.71e-03 | 1.78e-02 | 33 |
GO:00353041 | Colorectum | SER | regulation of protein dephosphorylation | 25/2897 | 90/18723 | 2.00e-03 | 1.98e-02 | 25 |
GO:00436661 | Colorectum | SER | regulation of phosphoprotein phosphatase activity | 18/2897 | 58/18723 | 2.18e-03 | 2.11e-02 | 18 |
GO:00163111 | Colorectum | SER | dephosphorylation | 86/2897 | 417/18723 | 2.73e-03 | 2.46e-02 | 86 |
GO:00435421 | Colorectum | SER | endothelial cell migration | 61/2897 | 279/18723 | 2.76e-03 | 2.47e-02 | 61 |
GO:19016541 | Colorectum | SER | response to ketone | 44/2897 | 194/18723 | 5.01e-03 | 3.88e-02 | 44 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00510982 | Colorectum | MSS | regulation of binding | 113/3467 | 363/18723 | 3.55e-09 | 2.41e-07 | 113 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:00097552 | Colorectum | MSS | hormone-mediated signaling pathway | 63/3467 | 190/18723 | 9.26e-07 | 3.23e-05 | 63 |
GO:00610082 | Colorectum | MSS | hepaticobiliary system development | 51/3467 | 150/18723 | 4.33e-06 | 1.23e-04 | 51 |
GO:00018892 | Colorectum | MSS | liver development | 50/3467 | 147/18723 | 5.28e-06 | 1.44e-04 | 50 |
GO:19016542 | Colorectum | MSS | response to ketone | 58/3467 | 194/18723 | 7.70e-05 | 1.28e-03 | 58 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502018 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0502019 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0502044 | Cervix | N_HPV | Prion disease | 39/349 | 273/8465 | 6.07e-12 | 4.13e-10 | 3.23e-10 | 39 |
hsa0502244 | Cervix | N_HPV | Pathways of neurodegeneration - multiple diseases | 47/349 | 476/8465 | 1.48e-08 | 3.13e-07 | 2.45e-07 | 47 |
hsa0501044 | Cervix | N_HPV | Alzheimer disease | 41/349 | 384/8465 | 1.50e-08 | 3.13e-07 | 2.45e-07 | 41 |
hsa0413724 | Cervix | N_HPV | Mitophagy - animal | 10/349 | 72/8465 | 6.84e-04 | 5.03e-03 | 3.93e-03 | 10 |
hsa0502054 | Cervix | N_HPV | Prion disease | 39/349 | 273/8465 | 6.07e-12 | 4.13e-10 | 3.23e-10 | 39 |
hsa0502254 | Cervix | N_HPV | Pathways of neurodegeneration - multiple diseases | 47/349 | 476/8465 | 1.48e-08 | 3.13e-07 | 2.45e-07 | 47 |
hsa0501054 | Cervix | N_HPV | Alzheimer disease | 41/349 | 384/8465 | 1.50e-08 | 3.13e-07 | 2.45e-07 | 41 |
hsa0413734 | Cervix | N_HPV | Mitophagy - animal | 10/349 | 72/8465 | 6.84e-04 | 5.03e-03 | 3.93e-03 | 10 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05020 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSNK2B | SNV | Missense_Mutation | novel | c.70G>A | p.Glu24Lys | p.E24K | P67870 | protein_coding | deleterious(0.01) | possibly_damaging(0.904) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CSNK2B | SNV | Missense_Mutation | novel | c.283N>A | p.Ala95Thr | p.A95T | P67870 | protein_coding | tolerated(0.18) | benign(0.035) | TCGA-S3-A6ZH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
CSNK2B | SNV | Missense_Mutation | c.608N>T | p.Ala203Val | p.A203V | P67870 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK2B | SNV | Missense_Mutation | c.377N>G | p.Asp126Gly | p.D126G | P67870 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK2B | SNV | Missense_Mutation | c.52N>A | p.Gly18Ser | p.G18S | P67870 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CSNK2B | SNV | Missense_Mutation | novel | c.553N>T | p.Pro185Ser | p.P185S | P67870 | protein_coding | deleterious(0.02) | benign(0.409) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
CSNK2B | SNV | Missense_Mutation | novel | c.638C>T | p.Thr213Met | p.T213M | P67870 | protein_coding | tolerated_low_confidence(0.13) | benign(0.033) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CSNK2B | SNV | Missense_Mutation | novel | c.295G>A | p.Glu99Lys | p.E99K | P67870 | protein_coding | deleterious(0.02) | benign(0.053) | TCGA-AX-A2HH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CSNK2B | SNV | Missense_Mutation | c.253N>A | p.Ala85Thr | p.A85T | P67870 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-D1-A1NY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
CSNK2B | SNV | Missense_Mutation | novel | c.101N>G | p.Phe34Cys | p.F34C | P67870 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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