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Gene: CSNK1G3 |
Gene summary for CSNK1G3 |
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Gene information | Species | Human | Gene symbol | CSNK1G3 | Gene ID | 1456 |
Gene name | casein kinase 1 gamma 3 | |
Gene Alias | CKI-gamma 3 | |
Cytomap | 5q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9Y6M4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1456 | CSNK1G3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.66e-19 | -6.35e-01 | 0.0155 |
1456 | CSNK1G3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.45e-04 | -4.77e-01 | -0.1808 |
1456 | CSNK1G3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.04e-02 | -6.76e-01 | 0.0216 |
1456 | CSNK1G3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.95e-03 | -4.24e-01 | -0.0811 |
1456 | CSNK1G3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.59e-06 | -5.86e-01 | -0.1207 |
1456 | CSNK1G3 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.01e-11 | -4.27e-01 | -0.1464 |
1456 | CSNK1G3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.79e-09 | -4.06e-01 | -0.1001 |
1456 | CSNK1G3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.93e-13 | -5.93e-01 | -0.059 |
1456 | CSNK1G3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.92e-02 | -6.76e-01 | -0.1462 |
1456 | CSNK1G3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.34e-11 | -5.49e-01 | 0.096 |
1456 | CSNK1G3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.46e-04 | -6.71e-01 | 0.0528 |
1456 | CSNK1G3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.31e-05 | -5.22e-01 | 0.0338 |
1456 | CSNK1G3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.09e-16 | -5.30e-01 | 0.0674 |
1456 | CSNK1G3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.84e-03 | -5.13e-01 | 0.0588 |
1456 | CSNK1G3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.02e-13 | -3.95e-01 | 0.294 |
1456 | CSNK1G3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.81e-09 | -4.38e-01 | 0.3859 |
1456 | CSNK1G3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.79e-23 | -5.73e-01 | 0.3005 |
1456 | CSNK1G3 | A002-C-010 | Human | Colorectum | FAP | 4.96e-02 | -1.80e-01 | 0.242 |
1456 | CSNK1G3 | A001-C-207 | Human | Colorectum | FAP | 2.01e-02 | -2.11e-01 | 0.1278 |
1456 | CSNK1G3 | A015-C-203 | Human | Colorectum | FAP | 1.78e-34 | -5.25e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003017724 | Skin | cSCC | positive regulation of Wnt signaling pathway | 55/4864 | 140/18723 | 3.72e-04 | 2.92e-03 | 55 |
GO:006007024 | Skin | cSCC | canonical Wnt signaling pathway | 104/4864 | 303/18723 | 7.13e-04 | 5.03e-03 | 104 |
GO:006082824 | Skin | cSCC | regulation of canonical Wnt signaling pathway | 87/4864 | 253/18723 | 1.74e-03 | 1.06e-02 | 87 |
GO:001820923 | Skin | cSCC | peptidyl-serine modification | 108/4864 | 338/18723 | 7.73e-03 | 3.60e-02 | 108 |
GO:0016055110 | Thyroid | PTC | Wnt signaling pathway | 217/5968 | 444/18723 | 3.71e-14 | 2.30e-12 | 217 |
GO:0198738110 | Thyroid | PTC | cell-cell signaling by wnt | 217/5968 | 446/18723 | 6.68e-14 | 3.73e-12 | 217 |
GO:0030111110 | Thyroid | PTC | regulation of Wnt signaling pathway | 163/5968 | 328/18723 | 1.05e-11 | 4.29e-10 | 163 |
GO:0060828110 | Thyroid | PTC | regulation of canonical Wnt signaling pathway | 123/5968 | 253/18723 | 1.83e-08 | 4.26e-07 | 123 |
GO:0060070110 | Thyroid | PTC | canonical Wnt signaling pathway | 141/5968 | 303/18723 | 5.71e-08 | 1.21e-06 | 141 |
GO:001810518 | Thyroid | PTC | peptidyl-serine phosphorylation | 143/5968 | 315/18723 | 2.94e-07 | 5.04e-06 | 143 |
GO:001820916 | Thyroid | PTC | peptidyl-serine modification | 151/5968 | 338/18723 | 4.61e-07 | 7.51e-06 | 151 |
GO:003017719 | Thyroid | PTC | positive regulation of Wnt signaling pathway | 72/5968 | 140/18723 | 1.16e-06 | 1.69e-05 | 72 |
GO:009026319 | Thyroid | PTC | positive regulation of canonical Wnt signaling pathway | 55/5968 | 106/18723 | 1.45e-05 | 1.55e-04 | 55 |
GO:001605525 | Thyroid | ATC | Wnt signaling pathway | 234/6293 | 444/18723 | 4.64e-17 | 4.31e-15 | 234 |
GO:019873825 | Thyroid | ATC | cell-cell signaling by wnt | 234/6293 | 446/18723 | 9.26e-17 | 8.25e-15 | 234 |
GO:003011125 | Thyroid | ATC | regulation of Wnt signaling pathway | 177/6293 | 328/18723 | 1.83e-14 | 1.05e-12 | 177 |
GO:006082825 | Thyroid | ATC | regulation of canonical Wnt signaling pathway | 134/6293 | 253/18723 | 1.49e-10 | 4.56e-09 | 134 |
GO:006007025 | Thyroid | ATC | canonical Wnt signaling pathway | 154/6293 | 303/18723 | 3.68e-10 | 1.02e-08 | 154 |
GO:0030177110 | Thyroid | ATC | positive regulation of Wnt signaling pathway | 80/6293 | 140/18723 | 8.75e-09 | 1.86e-07 | 80 |
GO:001810519 | Thyroid | ATC | peptidyl-serine phosphorylation | 153/6293 | 315/18723 | 2.28e-08 | 4.42e-07 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSNK1G3 | SNV | Missense_Mutation | c.439N>G | p.Ile147Val | p.I147V | Q9Y6M4 | protein_coding | tolerated(0.16) | benign(0.023) | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK1G3 | SNV | Missense_Mutation | novel | c.464N>T | p.Ser155Leu | p.S155L | Q9Y6M4 | protein_coding | deleterious(0.03) | benign(0.14) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
CSNK1G3 | SNV | Missense_Mutation | c.1018N>A | p.Asp340Asn | p.D340N | Q9Y6M4 | protein_coding | tolerated(0.06) | possibly_damaging(0.543) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
CSNK1G3 | SNV | Missense_Mutation | c.301N>G | p.Gln101Glu | p.Q101E | Q9Y6M4 | protein_coding | tolerated(0.19) | benign(0.042) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
CSNK1G3 | SNV | Missense_Mutation | c.710A>G | p.His237Arg | p.H237R | Q9Y6M4 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CSNK1G3 | SNV | Missense_Mutation | c.224C>A | p.Pro75His | p.P75H | Q9Y6M4 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK1G3 | SNV | Missense_Mutation | c.191A>G | p.Tyr64Cys | p.Y64C | Q9Y6M4 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK1G3 | SNV | Missense_Mutation | c.881N>C | p.Asp294Ala | p.D294A | Q9Y6M4 | protein_coding | deleterious(0.01) | possibly_damaging(0.829) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CSNK1G3 | SNV | Missense_Mutation | novel | c.245N>C | p.Gln82Pro | p.Q82P | Q9Y6M4 | protein_coding | deleterious(0) | possibly_damaging(0.875) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CSNK1G3 | SNV | Missense_Mutation | novel | c.760N>A | p.Ala254Thr | p.A254T | Q9Y6M4 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1456 | CSNK1G3 | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | TAK-715 | TAK-715 | ||
1456 | CSNK1G3 | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | CENISERTIB | CENISERTIB | ||
1456 | CSNK1G3 | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | inhibitor | 249565894 | ||
1456 | CSNK1G3 | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | SP-600125 | SP-600125 | ||
1456 | CSNK1G3 | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | PHA-767491 | CHEMBL225519 | ||
1456 | CSNK1G3 | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | GS 6201 | GS 6201 |
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