Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CLIC4_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CLIC4_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CLIC4_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CLIC4_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CLIC4_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CLIC4_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CLIC4_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007124817 | Oral cavity | EOLP | cellular response to metal ion | 35/2218 | 197/18723 | 9.17e-03 | 4.17e-02 | 35 |
GO:000716333 | Oral cavity | NEOLP | establishment or maintenance of cell polarity | 53/2005 | 218/18723 | 7.21e-09 | 3.82e-07 | 53 |
GO:005127115 | Oral cavity | NEOLP | negative regulation of cellular component movement | 70/2005 | 367/18723 | 1.10e-06 | 2.90e-05 | 70 |
GO:200014615 | Oral cavity | NEOLP | negative regulation of cell motility | 68/2005 | 359/18723 | 2.01e-06 | 4.77e-05 | 68 |
GO:01500631 | Oral cavity | NEOLP | visual system development | 70/2005 | 375/18723 | 2.46e-06 | 5.64e-05 | 70 |
GO:000165411 | Oral cavity | NEOLP | eye development | 69/2005 | 371/18723 | 3.30e-06 | 7.40e-05 | 69 |
GO:003033614 | Oral cavity | NEOLP | negative regulation of cell migration | 65/2005 | 344/18723 | 3.65e-06 | 7.97e-05 | 65 |
GO:00488801 | Oral cavity | NEOLP | sensory system development | 70/2005 | 381/18723 | 4.38e-06 | 9.42e-05 | 70 |
GO:000315823 | Oral cavity | NEOLP | endothelium development | 33/2005 | 136/18723 | 4.94e-06 | 1.04e-04 | 33 |
GO:000206424 | Oral cavity | NEOLP | epithelial cell development | 45/2005 | 220/18723 | 1.45e-05 | 2.54e-04 | 45 |
GO:004001314 | Oral cavity | NEOLP | negative regulation of locomotion | 69/2005 | 391/18723 | 2.05e-05 | 3.41e-04 | 69 |
GO:003021631 | Oral cavity | NEOLP | keratinocyte differentiation | 32/2005 | 139/18723 | 2.16e-05 | 3.57e-04 | 32 |
GO:001003833 | Oral cavity | NEOLP | response to metal ion | 66/2005 | 373/18723 | 2.83e-05 | 4.34e-04 | 66 |
GO:004544622 | Oral cavity | NEOLP | endothelial cell differentiation | 27/2005 | 118/18723 | 1.03e-04 | 1.24e-03 | 27 |
GO:000854431 | Oral cavity | NEOLP | epidermis development | 57/2005 | 324/18723 | 1.13e-04 | 1.35e-03 | 57 |
GO:004358831 | Oral cavity | NEOLP | skin development | 48/2005 | 263/18723 | 1.56e-04 | 1.77e-03 | 48 |
GO:0043010 | Oral cavity | NEOLP | camera-type eye development | 55/2005 | 322/18723 | 3.20e-04 | 3.11e-03 | 55 |
GO:000991331 | Oral cavity | NEOLP | epidermal cell differentiation | 38/2005 | 202/18723 | 3.92e-04 | 3.64e-03 | 38 |
GO:000188524 | Oral cavity | NEOLP | endothelial cell development | 16/2005 | 64/18723 | 9.25e-04 | 7.19e-03 | 16 |
GO:003526413 | Oral cavity | NEOLP | multicellular organism growth | 25/2005 | 132/18723 | 3.27e-03 | 1.95e-02 | 25 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLIC4 | SNV | Missense_Mutation | rs779954576 | c.257N>T | p.Thr86Met | p.T86M | Q9Y696 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLIC4 | SNV | Missense_Mutation | novel | c.16N>A | p.Pro6Thr | p.P6T | Q9Y696 | protein_coding | deleterious_low_confidence(0.03) | benign(0.151) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
CLIC4 | SNV | Missense_Mutation | | c.647G>A | p.Gly216Asp | p.G216D | Q9Y696 | protein_coding | deleterious(0) | possibly_damaging(0.826) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLIC4 | SNV | Missense_Mutation | | c.283C>A | p.Leu95Ile | p.L95I | Q9Y696 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CLIC4 | SNV | Missense_Mutation | novel | c.468N>G | p.Asn156Lys | p.N156K | Q9Y696 | protein_coding | tolerated(0.29) | benign(0.054) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CLIC4 | SNV | Missense_Mutation | rs144375143 | c.617G>A | p.Arg206His | p.R206H | Q9Y696 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CLIC4 | SNV | Missense_Mutation | | c.375N>A | p.Phe125Leu | p.F125L | Q9Y696 | protein_coding | deleterious(0.04) | benign(0.166) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
CLIC4 | SNV | Missense_Mutation | | c.109T>C | p.Phe37Leu | p.F37L | Q9Y696 | protein_coding | deleterious(0.04) | probably_damaging(0.92) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLIC4 | SNV | Missense_Mutation | novel | c.307N>G | p.Lys103Glu | p.K103E | Q9Y696 | protein_coding | tolerated(0.11) | possibly_damaging(0.795) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLIC4 | deletion | Frame_Shift_Del | | c.612delA | p.Lys204AsnfsTer11 | p.K204Nfs*11 | Q9Y696 | protein_coding | | | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |