Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CHP2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CHP2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CHP2_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19045894 | Colorectum | CRC | regulation of protein import | 16/2078 | 63/18723 | 1.13e-03 | 1.31e-02 | 16 |
GO:00170385 | Colorectum | CRC | protein import | 38/2078 | 206/18723 | 1.14e-03 | 1.31e-02 | 38 |
GO:00423074 | Colorectum | CRC | positive regulation of protein import into nucleus | 12/2078 | 41/18723 | 1.23e-03 | 1.38e-02 | 12 |
GO:00511705 | Colorectum | CRC | import into nucleus | 31/2078 | 159/18723 | 1.25e-03 | 1.41e-02 | 31 |
GO:00066065 | Colorectum | CRC | protein import into nucleus | 30/2078 | 155/18723 | 1.67e-03 | 1.73e-02 | 30 |
GO:0097720 | Colorectum | CRC | calcineurin-mediated signaling | 13/2078 | 48/18723 | 1.72e-03 | 1.77e-02 | 13 |
GO:0033173 | Colorectum | CRC | calcineurin-NFAT signaling cascade | 12/2078 | 43/18723 | 1.93e-03 | 1.96e-02 | 12 |
GO:19045913 | Colorectum | CRC | positive regulation of protein import | 12/2078 | 43/18723 | 1.93e-03 | 1.96e-02 | 12 |
GO:00480161 | Colorectum | CRC | inositol phosphate-mediated signaling | 14/2078 | 55/18723 | 2.21e-03 | 2.15e-02 | 14 |
GO:0070884 | Colorectum | CRC | regulation of calcineurin-NFAT signaling cascade | 10/2078 | 34/18723 | 2.96e-03 | 2.66e-02 | 10 |
GO:0106056 | Colorectum | CRC | regulation of calcineurin-mediated signaling | 10/2078 | 35/18723 | 3.74e-03 | 3.14e-02 | 10 |
GO:19001805 | Colorectum | CRC | regulation of protein localization to nucleus | 26/2078 | 136/18723 | 3.91e-03 | 3.24e-02 | 26 |
GO:00353062 | Colorectum | CRC | positive regulation of dephosphorylation | 14/2078 | 59/18723 | 4.42e-03 | 3.47e-02 | 14 |
GO:00109215 | Colorectum | CRC | regulation of phosphatase activity | 18/2078 | 84/18723 | 4.43e-03 | 3.47e-02 | 18 |
GO:00100386 | Stomach | GC | response to metal ion | 52/1159 | 373/18723 | 3.24e-08 | 2.44e-06 | 52 |
GO:19049516 | Stomach | GC | positive regulation of establishment of protein localization | 39/1159 | 319/18723 | 3.79e-05 | 9.76e-04 | 39 |
GO:00712416 | Stomach | GC | cellular response to inorganic substance | 30/1159 | 226/18723 | 6.50e-05 | 1.46e-03 | 30 |
GO:00712486 | Stomach | GC | cellular response to metal ion | 27/1159 | 197/18723 | 8.57e-05 | 1.79e-03 | 27 |
GO:00512226 | Stomach | GC | positive regulation of protein transport | 36/1159 | 303/18723 | 1.33e-04 | 2.49e-03 | 36 |
GO:00725946 | Stomach | GC | establishment of protein localization to organelle | 43/1159 | 422/18723 | 9.14e-04 | 1.11e-02 | 43 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHP2 | SNV | Missense_Mutation | rs138042112 | c.523N>A | p.Val175Met | p.V175M | O43745 | protein_coding | tolerated(0.08) | benign(0) | TCGA-A1-A0SG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
CHP2 | SNV | Missense_Mutation | novel | c.326N>C | p.Leu109Pro | p.L109P | O43745 | protein_coding | deleterious(0.04) | benign(0.071) | TCGA-AC-A62V-01 | Breast | breast invasive carcinoma | Male | <65 | III/IV | Targeted Molecular therapy | denosumab | PD |
CHP2 | SNV | Missense_Mutation | novel | c.462G>T | p.Glu154Asp | p.E154D | O43745 | protein_coding | tolerated(0.45) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHP2 | SNV | Missense_Mutation | rs773423633 | c.475N>T | p.Arg159Cys | p.R159C | O43745 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHP2 | SNV | Missense_Mutation | | c.479N>T | p.Thr160Met | p.T160M | O43745 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
CHP2 | SNV | Missense_Mutation | novel | c.289G>T | p.Asp97Tyr | p.D97Y | O43745 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHP2 | SNV | Missense_Mutation | rs756892483 | c.512N>T | p.Ala171Val | p.A171V | O43745 | protein_coding | tolerated(0.28) | benign(0.027) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHP2 | SNV | Missense_Mutation | novel | c.344A>C | p.Lys115Thr | p.K115T | O43745 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
CHP2 | SNV | Missense_Mutation | rs368850634 | c.289N>A | p.Asp97Asn | p.D97N | O43745 | protein_coding | tolerated(0.32) | benign(0.013) | TCGA-AX-A06D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
CHP2 | SNV | Missense_Mutation | rs751008002 | c.578N>A | p.Arg193Gln | p.R193Q | O43745 | protein_coding | deleterious(0.02) | benign(0.34) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |