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Gene: CDC37 |
Gene summary for CDC37 |
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Gene information | Species | Human | Gene symbol | CDC37 | Gene ID | 11140 |
Gene name | cell division cycle 37, HSP90 cochaperone | |
Gene Alias | P50CDC37 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000079 | UniProtAcc | A0A024R7B7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11140 | CDC37 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.77e-04 | 2.51e-01 | 0.0155 |
11140 | CDC37 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.25e-11 | 7.99e-01 | -0.0811 |
11140 | CDC37 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.77e-13 | 5.76e-01 | -0.1954 |
11140 | CDC37 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.75e-05 | 1.03e+00 | -0.2602 |
11140 | CDC37 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.91e-02 | 7.41e-01 | -0.2196 |
11140 | CDC37 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.80e-03 | 5.44e-01 | -0.1207 |
11140 | CDC37 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.34e-16 | 7.11e-01 | -0.1464 |
11140 | CDC37 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.59e-18 | 9.91e-01 | -0.059 |
11140 | CDC37 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.04e-04 | 8.36e-01 | -0.1706 |
11140 | CDC37 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.70e-03 | 6.15e-01 | -0.1462 |
11140 | CDC37 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.24e-11 | 5.63e-01 | 0.096 |
11140 | CDC37 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.43e-02 | 3.98e-01 | 0.0338 |
11140 | CDC37 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.53e-13 | 7.11e-01 | 0.0674 |
11140 | CDC37 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.78e-07 | 5.54e-01 | 0.0588 |
11140 | CDC37 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.20e-20 | 8.27e-01 | 0.294 |
11140 | CDC37 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.16e-16 | 9.84e-01 | 0.281 |
11140 | CDC37 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.54e-22 | 1.05e+00 | 0.3859 |
11140 | CDC37 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.53e-05 | 4.97e-01 | 0.3005 |
11140 | CDC37 | A015-C-203 | Human | Colorectum | FAP | 7.83e-09 | 4.61e-02 | -0.1294 |
11140 | CDC37 | A001-C-108 | Human | Colorectum | FAP | 7.35e-03 | 1.07e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000042217 | Esophagus | ESCC | autophagy of mitochondrion | 63/8552 | 81/18723 | 3.41e-09 | 7.24e-08 | 63 |
GO:006172617 | Esophagus | ESCC | mitochondrion disassembly | 63/8552 | 81/18723 | 3.41e-09 | 7.24e-08 | 63 |
GO:003434013 | Esophagus | ESCC | response to type I interferon | 48/8552 | 58/18723 | 6.18e-09 | 1.26e-07 | 48 |
GO:00603375 | Esophagus | ESCC | type I interferon signaling pathway | 41/8552 | 50/18723 | 1.35e-07 | 2.17e-06 | 41 |
GO:00713575 | Esophagus | ESCC | cellular response to type I interferon | 42/8552 | 52/18723 | 2.15e-07 | 3.30e-06 | 42 |
GO:19040294 | Esophagus | ESCC | regulation of cyclin-dependent protein kinase activity | 69/8552 | 98/18723 | 6.04e-07 | 7.91e-06 | 69 |
GO:00000794 | Esophagus | ESCC | regulation of cyclin-dependent protein serine/threonine kinase activity | 66/8552 | 94/18723 | 1.24e-06 | 1.53e-05 | 66 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:00607595 | Esophagus | ESCC | regulation of response to cytokine stimulus | 103/8552 | 162/18723 | 3.14e-06 | 3.53e-05 | 103 |
GO:00019595 | Esophagus | ESCC | regulation of cytokine-mediated signaling pathway | 95/8552 | 150/18723 | 9.48e-06 | 9.04e-05 | 95 |
GO:00603385 | Esophagus | ESCC | regulation of type I interferon-mediated signaling pathway | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
GO:006191215 | Esophagus | ESCC | selective autophagy | 47/8552 | 68/18723 | 7.81e-05 | 5.80e-04 | 47 |
GO:00603336 | Esophagus | ESCC | interferon-gamma-mediated signaling pathway | 22/8552 | 27/18723 | 1.49e-04 | 9.92e-04 | 22 |
GO:00343418 | Esophagus | ESCC | response to interferon-gamma | 86/8552 | 141/18723 | 1.74e-04 | 1.14e-03 | 86 |
GO:00450885 | Esophagus | ESCC | regulation of innate immune response | 125/8552 | 218/18723 | 3.34e-04 | 1.96e-03 | 125 |
GO:00987806 | Esophagus | ESCC | response to mitochondrial depolarisation | 16/8552 | 19/18723 | 6.45e-04 | 3.43e-03 | 16 |
GO:000042315 | Esophagus | ESCC | mitophagy | 21/8552 | 28/18723 | 1.57e-03 | 7.33e-03 | 21 |
GO:19049233 | Esophagus | ESCC | regulation of autophagy of mitochondrion in response to mitochondrial depolarization | 12/8552 | 14/18723 | 2.51e-03 | 1.08e-02 | 12 |
GO:00713466 | Esophagus | ESCC | cellular response to interferon-gamma | 69/8552 | 118/18723 | 3.44e-03 | 1.41e-02 | 69 |
GO:19049254 | Esophagus | ESCC | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04151 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041511 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0415113 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0415123 | Oral cavity | EOLP | PI3K-Akt signaling pathway | 73/1218 | 354/8465 | 7.03e-04 | 2.69e-03 | 1.59e-03 | 73 |
hsa0415133 | Oral cavity | EOLP | PI3K-Akt signaling pathway | 73/1218 | 354/8465 | 7.03e-04 | 2.69e-03 | 1.59e-03 | 73 |
hsa0415141 | Oral cavity | NEOLP | PI3K-Akt signaling pathway | 79/1112 | 354/8465 | 8.42e-07 | 9.92e-06 | 6.24e-06 | 79 |
hsa0415151 | Oral cavity | NEOLP | PI3K-Akt signaling pathway | 79/1112 | 354/8465 | 8.42e-07 | 9.92e-06 | 6.24e-06 | 79 |
hsa041515 | Prostate | BPH | PI3K-Akt signaling pathway | 104/1718 | 354/8465 | 2.07e-05 | 1.55e-04 | 9.61e-05 | 104 |
hsa0415112 | Prostate | BPH | PI3K-Akt signaling pathway | 104/1718 | 354/8465 | 2.07e-05 | 1.55e-04 | 9.61e-05 | 104 |
hsa0415122 | Prostate | Tumor | PI3K-Akt signaling pathway | 105/1791 | 354/8465 | 7.42e-05 | 5.30e-04 | 3.28e-04 | 105 |
hsa0415132 | Prostate | Tumor | PI3K-Akt signaling pathway | 105/1791 | 354/8465 | 7.42e-05 | 5.30e-04 | 3.28e-04 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC37 | SNV | Missense_Mutation | novel | c.650N>C | p.Gln217Pro | p.Q217P | Q16543 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CDC37 | SNV | Missense_Mutation | rs779190160 | c.691N>T | p.Arg231Trp | p.R231W | Q16543 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CDC37 | SNV | Missense_Mutation | c.56N>T | p.Thr19Met | p.T19M | Q16543 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-B6-A0I2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDC37 | SNV | Missense_Mutation | c.449C>T | p.Thr150Ile | p.T150I | Q16543 | protein_coding | tolerated(0.07) | possibly_damaging(0.673) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
CDC37 | SNV | Missense_Mutation | c.1027N>A | p.Val343Ile | p.V343I | Q16543 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-D8-A1JB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CDC37 | deletion | Frame_Shift_Del | novel | c.462delN | p.Lys154AsnfsTer44 | p.K154Nfs*44 | Q16543 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CDC37 | SNV | Missense_Mutation | novel | c.166N>A | p.Glu56Lys | p.E56K | Q16543 | protein_coding | tolerated(0.15) | benign(0.295) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
CDC37 | SNV | Missense_Mutation | rs751173951 | c.1004N>A | p.Arg335His | p.R335H | Q16543 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
CDC37 | SNV | Missense_Mutation | c.358N>G | p.Ser120Gly | p.S120G | Q16543 | protein_coding | tolerated(0.07) | possibly_damaging(0.579) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDC37 | SNV | Missense_Mutation | c.207N>T | p.Lys69Asn | p.K69N | Q16543 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11140 | CDC37 | KINASE | SODIUM MOLYBDATE | SODIUM MOLYBDATE | 21486005 | |
11140 | CDC37 | KINASE | GELDANAMYCIN | GELDANAMYCIN | 21486005 |
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