Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/CAMK2D_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CAMK2D_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CAMK2D_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CAMK2D_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CAMK2D_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CAMK2D_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CAMK2D_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CAMK2D_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CAMK2D_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CAMK2D_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CAMK2D_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0086064 | Colorectum | MSS | cell communication by electrical coupling involved in cardiac conduction | 11/3467 | 25/18723 | 2.96e-03 | 2.28e-02 | 11 |
GO:00181071 | Colorectum | MSS | peptidyl-threonine phosphorylation | 34/3467 | 116/18723 | 3.08e-03 | 2.34e-02 | 34 |
GO:00182101 | Colorectum | MSS | peptidyl-threonine modification | 36/3467 | 125/18723 | 3.28e-03 | 2.49e-02 | 36 |
GO:0022898 | Colorectum | MSS | regulation of transmembrane transporter activity | 70/3467 | 278/18723 | 3.36e-03 | 2.54e-02 | 70 |
GO:00100382 | Colorectum | MSS | response to metal ion | 90/3467 | 373/18723 | 3.76e-03 | 2.76e-02 | 90 |
GO:00510511 | Colorectum | MSS | negative regulation of transport | 110/3467 | 470/18723 | 4.20e-03 | 3.04e-02 | 110 |
GO:0070252 | Colorectum | MSS | actin-mediated cell contraction | 29/3467 | 97/18723 | 4.38e-03 | 3.10e-02 | 29 |
GO:0086003 | Colorectum | MSS | cardiac muscle cell contraction | 23/3467 | 73/18723 | 5.22e-03 | 3.57e-02 | 23 |
GO:00030121 | Colorectum | MSS | muscle system process | 105/3467 | 452/18723 | 6.39e-03 | 4.26e-02 | 105 |
GO:00310562 | Colorectum | MSS | regulation of histone modification | 41/3467 | 152/18723 | 6.41e-03 | 4.27e-02 | 41 |
GO:0032412 | Colorectum | MSS | regulation of ion transmembrane transporter activity | 66/3467 | 267/18723 | 6.72e-03 | 4.38e-02 | 66 |
GO:00712412 | Colorectum | MSS | cellular response to inorganic substance | 57/3467 | 226/18723 | 7.27e-03 | 4.64e-02 | 57 |
GO:1901844 | Colorectum | MSS | regulation of cell communication by electrical coupling involved in cardiac conduction | 6/3467 | 11/18723 | 7.89e-03 | 4.84e-02 | 6 |
GO:00329704 | Colorectum | FAP | regulation of actin filament-based process | 105/2622 | 397/18723 | 3.15e-11 | 1.38e-08 | 105 |
GO:00300483 | Colorectum | FAP | actin filament-based movement | 44/2622 | 127/18723 | 3.48e-09 | 5.93e-07 | 44 |
GO:00160493 | Colorectum | FAP | cell growth | 112/2622 | 482/18723 | 2.40e-08 | 2.30e-06 | 112 |
GO:00020284 | Colorectum | FAP | regulation of sodium ion transport | 33/2622 | 90/18723 | 6.51e-08 | 4.54e-06 | 33 |
GO:00015583 | Colorectum | FAP | regulation of cell growth | 95/2622 | 414/18723 | 5.02e-07 | 2.61e-05 | 95 |
GO:19023054 | Colorectum | FAP | regulation of sodium ion transmembrane transport | 25/2622 | 68/18723 | 2.36e-06 | 9.21e-05 | 25 |
GO:00989014 | Colorectum | FAP | regulation of cardiac muscle cell action potential | 14/2622 | 27/18723 | 3.58e-06 | 1.26e-04 | 14 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMK2D | SNV | Missense_Mutation | novel | c.709N>A | p.Glu237Lys | p.E237K | | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
CAMK2D | SNV | Missense_Mutation | | c.911T>C | p.Ile304Thr | p.I304T | | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.953) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAMK2D | SNV | Missense_Mutation | | c.1514N>A | p.Gly505Glu | p.G505E | | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.597) | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAMK2D | insertion | Frame_Shift_Ins | novel | c.70dupG | p.Ala24GlyfsTer30 | p.A24Gfs*30 | | protein_coding | | | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAMK2D | deletion | Frame_Shift_Del | novel | c.1417delN | p.Asp473MetfsTer64 | p.D473Mfs*64 | | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
CAMK2D | SNV | Missense_Mutation | | c.920C>T | p.Thr307Ile | p.T307I | | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.675) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CAMK2D | SNV | Missense_Mutation | | c.289N>C | p.Glu97Gln | p.E97Q | | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.999) | TCGA-AA-A02H-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CAMK2D | SNV | Missense_Mutation | novel | c.1328C>G | p.Pro443Arg | p.P443R | | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.994) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CAMK2D | SNV | Missense_Mutation | novel | c.1327C>T | p.Pro443Ser | p.P443S | | protein_coding | tolerated_low_confidence(0.1) | probably_damaging(0.991) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CAMK2D | SNV | Missense_Mutation | | c.509N>T | p.Ala170Val | p.A170V | | protein_coding | tolerated_low_confidence(0.08) | probably_damaging(0.999) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | GEFITINIB | GEFITINIB | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | GW441756X | GW441756X | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | TAE-684 | TAE-684 | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | SP-600125 | SP-600125 | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | LY-2090314 | LY-2090314 | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | LINIFANIB | LINIFANIB | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | ILORASERTIB | ILORASERTIB | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | SOTRASTAURIN | SOTRASTAURIN | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | | PF-562271 | PF-00562271 | |
817 | CAMK2D | TRANSCRIPTION FACTOR, TRANSPORTER, ENZYME, ION CHANNEL, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | inhibitor | 249565838 | | |