![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: BAIAP2L2 |
Gene summary for BAIAP2L2 |
![]() |
Gene information | Species | Human | Gene symbol | BAIAP2L2 | Gene ID | 80115 |
Gene name | BAR/IMD domain containing adaptor protein 2 like 2 | |
Gene Alias | BAIAP2L2 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q6UXY1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80115 | BAIAP2L2 | Tumor | Human | Cervix | CC | 2.63e-57 | 9.64e-01 | 0.1241 |
80115 | BAIAP2L2 | sample3 | Human | Cervix | CC | 3.80e-69 | 1.00e+00 | 0.1387 |
80115 | BAIAP2L2 | T3 | Human | Cervix | CC | 1.31e-68 | 9.55e-01 | 0.1389 |
80115 | BAIAP2L2 | P4T-E | Human | Esophagus | ESCC | 2.81e-07 | 2.06e-01 | 0.1323 |
80115 | BAIAP2L2 | P5T-E | Human | Esophagus | ESCC | 8.96e-45 | 8.34e-01 | 0.1327 |
80115 | BAIAP2L2 | P9T-E | Human | Esophagus | ESCC | 6.89e-11 | 3.52e-01 | 0.1131 |
80115 | BAIAP2L2 | P11T-E | Human | Esophagus | ESCC | 4.74e-03 | 1.89e-01 | 0.1426 |
80115 | BAIAP2L2 | P17T-E | Human | Esophagus | ESCC | 2.14e-09 | 5.06e-01 | 0.1278 |
80115 | BAIAP2L2 | P19T-E | Human | Esophagus | ESCC | 4.64e-06 | 4.31e-01 | 0.1662 |
80115 | BAIAP2L2 | P20T-E | Human | Esophagus | ESCC | 1.17e-04 | 1.62e-01 | 0.1124 |
80115 | BAIAP2L2 | P21T-E | Human | Esophagus | ESCC | 2.85e-73 | 1.65e+00 | 0.1617 |
80115 | BAIAP2L2 | P23T-E | Human | Esophagus | ESCC | 6.05e-08 | 2.94e-01 | 0.108 |
80115 | BAIAP2L2 | P24T-E | Human | Esophagus | ESCC | 6.56e-15 | 3.55e-01 | 0.1287 |
80115 | BAIAP2L2 | P28T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.90e-01 | 0.1149 |
80115 | BAIAP2L2 | P30T-E | Human | Esophagus | ESCC | 9.20e-05 | 3.15e-01 | 0.137 |
80115 | BAIAP2L2 | P32T-E | Human | Esophagus | ESCC | 1.45e-46 | 1.18e+00 | 0.1666 |
80115 | BAIAP2L2 | P37T-E | Human | Esophagus | ESCC | 5.50e-16 | 4.67e-01 | 0.1371 |
80115 | BAIAP2L2 | P38T-E | Human | Esophagus | ESCC | 6.38e-15 | 5.53e-01 | 0.127 |
80115 | BAIAP2L2 | P39T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.67e-01 | 0.0894 |
80115 | BAIAP2L2 | P40T-E | Human | Esophagus | ESCC | 2.35e-12 | 4.70e-01 | 0.109 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032970110 | Oral cavity | LP | regulation of actin filament-based process | 133/4623 | 397/18723 | 4.21e-05 | 6.09e-04 | 133 |
GO:005149519 | Oral cavity | LP | positive regulation of cytoskeleton organization | 82/4623 | 226/18723 | 6.26e-05 | 8.46e-04 | 82 |
GO:0032535110 | Oral cavity | LP | regulation of cellular component size | 128/4623 | 383/18723 | 6.56e-05 | 8.80e-04 | 128 |
GO:003083818 | Oral cavity | LP | positive regulation of actin filament polymerization | 42/4623 | 99/18723 | 7.96e-05 | 1.03e-03 | 42 |
GO:003083319 | Oral cavity | LP | regulation of actin filament polymerization | 65/4623 | 172/18723 | 8.86e-05 | 1.11e-03 | 65 |
GO:0032956110 | Oral cavity | LP | regulation of actin cytoskeleton organization | 120/4623 | 358/18723 | 9.47e-05 | 1.18e-03 | 120 |
GO:0007015110 | Oral cavity | LP | actin filament organization | 143/4623 | 442/18723 | 1.44e-04 | 1.65e-03 | 143 |
GO:000806418 | Oral cavity | LP | regulation of actin polymerization or depolymerization | 69/4623 | 188/18723 | 1.55e-04 | 1.76e-03 | 69 |
GO:003083217 | Oral cavity | LP | regulation of actin filament length | 69/4623 | 189/18723 | 1.86e-04 | 2.05e-03 | 69 |
GO:003004119 | Oral cavity | LP | actin filament polymerization | 69/4623 | 191/18723 | 2.65e-04 | 2.75e-03 | 69 |
GO:000815419 | Oral cavity | LP | actin polymerization or depolymerization | 76/4623 | 218/18723 | 4.67e-04 | 4.42e-03 | 76 |
GO:0110053110 | Oral cavity | LP | regulation of actin filament organization | 92/4623 | 278/18723 | 9.25e-04 | 7.85e-03 | 92 |
GO:0051017110 | Oral cavity | LP | actin filament bundle assembly | 53/4623 | 157/18723 | 6.54e-03 | 3.83e-02 | 53 |
GO:003153217 | Oral cavity | LP | actin cytoskeleton reorganization | 38/4623 | 107/18723 | 7.93e-03 | 4.36e-02 | 38 |
GO:00070156 | Stomach | GC | actin filament organization | 67/1159 | 442/18723 | 7.96e-12 | 2.20e-09 | 67 |
GO:00432546 | Stomach | GC | regulation of protein-containing complex assembly | 58/1159 | 428/18723 | 1.48e-08 | 1.32e-06 | 58 |
GO:00313346 | Stomach | GC | positive regulation of protein-containing complex assembly | 39/1159 | 237/18723 | 2.00e-08 | 1.63e-06 | 39 |
GO:19029036 | Stomach | GC | regulation of supramolecular fiber organization | 53/1159 | 383/18723 | 3.07e-08 | 2.39e-06 | 53 |
GO:00329706 | Stomach | GC | regulation of actin filament-based process | 54/1159 | 397/18723 | 4.11e-08 | 2.85e-06 | 54 |
GO:00615726 | Stomach | GC | actin filament bundle organization | 30/1159 | 161/18723 | 5.07e-08 | 3.40e-06 | 30 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BAIAP2L2 | SNV | Missense_Mutation | c.331N>A | p.Asp111Asn | p.D111N | Q6UXY1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
BAIAP2L2 | SNV | Missense_Mutation | rs201026822 | c.115N>T | p.Arg39Cys | p.R39C | Q6UXY1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
BAIAP2L2 | SNV | Missense_Mutation | rs764609892 | c.211C>G | p.Leu71Val | p.L71V | Q6UXY1 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAIAP2L2 | SNV | Missense_Mutation | c.548G>A | p.Arg183His | p.R183H | Q6UXY1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BAIAP2L2 | SNV | Missense_Mutation | c.1031N>A | p.Leu344Gln | p.L344Q | Q6UXY1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BAIAP2L2 | SNV | Missense_Mutation | c.544N>T | p.Arg182Trp | p.R182W | Q6UXY1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BAIAP2L2 | SNV | Missense_Mutation | novel | c.424C>T | p.Arg142Cys | p.R142C | Q6UXY1 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
BAIAP2L2 | insertion | In_Frame_Ins | novel | c.1223_1224insAACACCCAT | p.Pro407_Met408insIleThrPro | p.P407_M408insITP | Q6UXY1 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
BAIAP2L2 | SNV | Missense_Mutation | rs201411605 | c.1175N>A | p.Pro392His | p.P392H | Q6UXY1 | protein_coding | tolerated(0.25) | possibly_damaging(0.753) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BAIAP2L2 | SNV | Missense_Mutation | rs761059410 | c.1547G>A | p.Arg516His | p.R516H | Q6UXY1 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |