Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: AUTS2

Gene summary for AUTS2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

AUTS2

Gene ID

26053

Gene nameactivator of transcription and developmental regulator AUTS2
Gene AliasFBRSL2
Cytomap7q11.22
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q8WXX7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
26053AUTS2CA_HPV_3HumanCervixCC2.42e-036.60e-020.0414
26053AUTS2CCI_2HumanCervixCC2.38e-058.16e-010.5249
26053AUTS2CCI_3HumanCervixCC4.81e-271.44e+000.516
26053AUTS2T1HumanCervixCC7.26e-063.69e-010.0918
26053AUTS2HTA11_1938_2000001011HumanColorectumAD1.36e-065.31e-01-0.0811
26053AUTS2HTA11_78_2000001011HumanColorectumAD2.18e-035.24e-01-0.1088
26053AUTS2HTA11_347_2000001011HumanColorectumAD8.59e-156.74e-01-0.1954
26053AUTS2HTA11_6818_2000001011HumanColorectumAD2.59e-057.23e-010.0112
26053AUTS2HTA11_6818_2000001021HumanColorectumAD7.40e-086.89e-010.0588
26053AUTS2HTA11_99999974143_84620HumanColorectumMSS9.45e-16-5.47e-010.3005
26053AUTS2A015-C-203HumanColorectumFAP4.60e-23-1.87e-01-0.1294
26053AUTS2A015-C-204HumanColorectumFAP1.14e-02-2.15e-01-0.0228
26053AUTS2A002-C-201HumanColorectumFAP1.88e-08-2.72e-010.0324
26053AUTS2A002-C-203HumanColorectumFAP1.63e-032.75e-010.2786
26053AUTS2A001-C-119HumanColorectumFAP2.97e-03-3.70e-01-0.1557
26053AUTS2A001-C-108HumanColorectumFAP1.15e-12-5.55e-02-0.0272
26053AUTS2A002-C-205HumanColorectumFAP1.54e-15-1.55e-01-0.1236
26053AUTS2A015-C-006HumanColorectumFAP8.08e-10-3.04e-01-0.0994
26053AUTS2A015-C-106HumanColorectumFAP2.66e-087.31e-03-0.0511
26053AUTS2A002-C-114HumanColorectumFAP2.23e-15-4.69e-01-0.1561
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00160494ColorectumCRCcell growth95/2078482/187231.51e-082.75e-0695
GO:00072653ColorectumCRCRas protein signal transduction70/2078337/187231.49e-071.66e-0570
GO:00975815ColorectumCRClamellipodium organization28/207890/187232.43e-072.27e-0528
GO:00605603ColorectumCRCdevelopmental growth involved in morphogenesis53/2078234/187232.88e-072.54e-0553
GO:00315324ColorectumCRCactin cytoskeleton reorganization31/2078107/187233.36e-072.83e-0531
GO:00074094ColorectumCRCaxonogenesis81/2078418/187233.60e-072.99e-0581
GO:19027435ColorectumCRCregulation of lamellipodium organization20/207854/187235.62e-074.00e-0520
GO:19027455ColorectumCRCpositive regulation of lamellipodium organization16/207837/187236.56e-074.50e-0516
GO:00615644ColorectumCRCaxon development86/2078467/187231.48e-068.12e-0586
GO:00465782ColorectumCRCregulation of Ras protein signal transduction43/2078189/187233.26e-061.47e-0443
GO:00485883ColorectumCRCdevelopmental cell growth50/2078234/187233.73e-061.61e-0450
GO:00105924ColorectumCRCpositive regulation of lamellipodium assembly13/207829/187234.55e-061.87e-0413
GO:00300323ColorectumCRClamellipodium assembly22/207872/187236.40e-062.47e-0422
GO:00313464ColorectumCRCpositive regulation of cell projection organization67/2078353/187237.45e-062.72e-0467
GO:19901382ColorectumCRCneuron projection extension39/2078172/187239.95e-063.31e-0439
GO:00486753ColorectumCRCaxon extension30/2078120/187231.40e-054.40e-0430
GO:00105914ColorectumCRCregulation of lamellipodium assembly15/207842/187232.41e-056.81e-0415
GO:00165702ColorectumCRChistone modification75/2078463/187234.95e-047.06e-0375
GO:01200324ColorectumCRCregulation of plasma membrane bounded cell projection assembly35/2078186/187231.22e-031.38e-0235
GO:00604913ColorectumCRCregulation of cell projection assembly35/2078188/187231.48e-031.58e-0235
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
AUTS2SNVMissense_Mutationnovelc.3679C>Ap.Leu1227Metp.L1227MQ8WXX7protein_codingdeleterious(0.05)probably_damaging(0.998)TCGA-A8-A09Q-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozoleSD
AUTS2SNVMissense_Mutationc.1429N>Gp.Leu477Valp.L477VQ8WXX7protein_codingdeleterious(0)benign(0.359)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
AUTS2SNVMissense_Mutationc.2284N>Cp.Gly762Argp.G762RQ8WXX7protein_codingdeleterious(0)probably_damaging(0.942)TCGA-BH-A0BZ-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinCR
AUTS2SNVMissense_Mutationc.2285N>Tp.Gly762Valp.G762VQ8WXX7protein_codingdeleterious(0)probably_damaging(0.999)TCGA-BH-A0BZ-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinCR
AUTS2SNVMissense_Mutationc.2335N>Tp.Asp779Tyrp.D779YQ8WXX7protein_codingdeleterious(0)probably_damaging(0.983)TCGA-BH-A0DH-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
AUTS2SNVMissense_Mutationnovelc.3664C>Gp.Pro1222Alap.P1222AQ8WXX7protein_codingdeleterious(0)probably_damaging(0.941)TCGA-OL-A5RW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
AUTS2insertionNonsense_Mutationnovelc.2058_2059insTAGGCAGTTGTATCCAGCACTGCGGGCGGAAATGATTCCATp.Leu687Terp.L687*Q8WXX7protein_codingTCGA-A8-A06Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
AUTS2SNVMissense_Mutationc.1549N>Tp.Pro517Serp.P517SQ8WXX7protein_codingtolerated(0.21)probably_damaging(0.93)TCGA-EK-A3GK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
AUTS2SNVMissense_Mutationc.2674G>Cp.Glu892Glnp.E892QQ8WXX7protein_codingdeleterious(0.01)possibly_damaging(0.542)TCGA-JX-A3Q0-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
AUTS2SNVMissense_Mutationc.1150G>Ap.Ala384Thrp.A384TQ8WXX7protein_codingtolerated(0.29)benign(0.001)TCGA-A6-5665-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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