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Gene: ATP6V0E1 |
Gene summary for ATP6V0E1 |
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Gene information | Species | Human | Gene symbol | ATP6V0E1 | Gene ID | 8992 |
Gene name | ATPase H+ transporting V0 subunit e1 | |
Gene Alias | ATP6H | |
Cytomap | 5q35.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O15342 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8992 | ATP6V0E1 | GSM4909286 | Human | Breast | IDC | 2.01e-36 | -6.07e-01 | 0.1081 |
8992 | ATP6V0E1 | GSM4909288 | Human | Breast | IDC | 2.69e-03 | -4.73e-01 | 0.0988 |
8992 | ATP6V0E1 | GSM4909294 | Human | Breast | IDC | 5.19e-06 | -2.81e-01 | 0.2022 |
8992 | ATP6V0E1 | GSM4909296 | Human | Breast | IDC | 4.37e-14 | -1.85e-01 | 0.1524 |
8992 | ATP6V0E1 | GSM4909297 | Human | Breast | IDC | 1.65e-23 | -3.65e-01 | 0.1517 |
8992 | ATP6V0E1 | GSM4909298 | Human | Breast | IDC | 5.09e-03 | 1.57e-01 | 0.1551 |
8992 | ATP6V0E1 | GSM4909301 | Human | Breast | IDC | 8.85e-03 | -2.50e-01 | 0.1577 |
8992 | ATP6V0E1 | GSM4909302 | Human | Breast | IDC | 1.06e-03 | 1.83e-01 | 0.1545 |
8992 | ATP6V0E1 | GSM4909308 | Human | Breast | IDC | 3.12e-09 | 3.26e-01 | 0.158 |
8992 | ATP6V0E1 | GSM4909309 | Human | Breast | IDC | 4.66e-04 | 1.36e-01 | 0.0483 |
8992 | ATP6V0E1 | GSM4909311 | Human | Breast | IDC | 6.18e-52 | -4.53e-01 | 0.1534 |
8992 | ATP6V0E1 | GSM4909312 | Human | Breast | IDC | 1.04e-14 | -2.75e-01 | 0.1552 |
8992 | ATP6V0E1 | GSM4909319 | Human | Breast | IDC | 2.48e-67 | -5.03e-01 | 0.1563 |
8992 | ATP6V0E1 | GSM4909320 | Human | Breast | IDC | 2.64e-06 | -3.53e-01 | 0.1575 |
8992 | ATP6V0E1 | GSM4909321 | Human | Breast | IDC | 1.18e-17 | -3.80e-02 | 0.1559 |
8992 | ATP6V0E1 | brca1 | Human | Breast | Precancer | 6.52e-30 | 5.60e-01 | -0.0338 |
8992 | ATP6V0E1 | brca2 | Human | Breast | Precancer | 1.75e-17 | 4.54e-01 | -0.024 |
8992 | ATP6V0E1 | brca3 | Human | Breast | Precancer | 1.77e-18 | 4.32e-01 | -0.0263 |
8992 | ATP6V0E1 | brca10 | Human | Breast | Precancer | 1.22e-09 | 3.43e-01 | -0.0029 |
8992 | ATP6V0E1 | M2 | Human | Breast | IDC | 3.17e-03 | -3.69e-01 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001624110 | Thyroid | PTC | regulation of macroautophagy | 84/5968 | 141/18723 | 1.04e-11 | 4.27e-10 | 84 |
GO:1902600111 | Thyroid | PTC | proton transmembrane transport | 72/5968 | 157/18723 | 1.64e-04 | 1.26e-03 | 72 |
GO:00070355 | Thyroid | PTC | vacuolar acidification | 15/5968 | 24/18723 | 1.95e-03 | 1.05e-02 | 15 |
GO:001623623 | Thyroid | ATC | macroautophagy | 169/6293 | 291/18723 | 6.56e-18 | 7.69e-16 | 169 |
GO:001050632 | Thyroid | ATC | regulation of autophagy | 180/6293 | 317/18723 | 1.34e-17 | 1.46e-15 | 180 |
GO:001624115 | Thyroid | ATC | regulation of macroautophagy | 86/6293 | 141/18723 | 2.35e-11 | 8.24e-10 | 86 |
GO:190260032 | Thyroid | ATC | proton transmembrane transport | 73/6293 | 157/18723 | 5.25e-04 | 3.06e-03 | 73 |
GO:000703512 | Thyroid | ATC | vacuolar acidification | 15/6293 | 24/18723 | 3.52e-03 | 1.56e-02 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0511014 | Breast | Precancer | Vibrio cholerae infection | 14/684 | 50/8465 | 2.67e-05 | 2.64e-04 | 2.02e-04 | 14 |
hsa0414518 | Breast | Precancer | Phagosome | 27/684 | 152/8465 | 7.37e-05 | 6.85e-04 | 5.25e-04 | 27 |
hsa0532312 | Breast | Precancer | Rheumatoid arthritis | 19/684 | 93/8465 | 1.30e-04 | 1.14e-03 | 8.73e-04 | 19 |
hsa051206 | Breast | Precancer | Epithelial cell signaling in Helicobacter pylori infection | 14/684 | 70/8465 | 1.21e-03 | 7.99e-03 | 6.12e-03 | 14 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0511015 | Breast | Precancer | Vibrio cholerae infection | 14/684 | 50/8465 | 2.67e-05 | 2.64e-04 | 2.02e-04 | 14 |
hsa0414519 | Breast | Precancer | Phagosome | 27/684 | 152/8465 | 7.37e-05 | 6.85e-04 | 5.25e-04 | 27 |
hsa0532313 | Breast | Precancer | Rheumatoid arthritis | 19/684 | 93/8465 | 1.30e-04 | 1.14e-03 | 8.73e-04 | 19 |
hsa0512013 | Breast | Precancer | Epithelial cell signaling in Helicobacter pylori infection | 14/684 | 70/8465 | 1.21e-03 | 7.99e-03 | 6.12e-03 | 14 |
hsa0019023 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0511022 | Breast | IDC | Vibrio cholerae infection | 17/867 | 50/8465 | 4.82e-06 | 6.82e-05 | 5.10e-05 | 17 |
hsa0414522 | Breast | IDC | Phagosome | 34/867 | 152/8465 | 8.00e-06 | 9.99e-05 | 7.48e-05 | 34 |
hsa0532321 | Breast | IDC | Rheumatoid arthritis | 21/867 | 93/8465 | 3.69e-04 | 3.15e-03 | 2.36e-03 | 21 |
hsa0512022 | Breast | IDC | Epithelial cell signaling in Helicobacter pylori infection | 16/867 | 70/8465 | 1.56e-03 | 1.13e-02 | 8.42e-03 | 16 |
hsa0019033 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0511032 | Breast | IDC | Vibrio cholerae infection | 17/867 | 50/8465 | 4.82e-06 | 6.82e-05 | 5.10e-05 | 17 |
hsa0414532 | Breast | IDC | Phagosome | 34/867 | 152/8465 | 8.00e-06 | 9.99e-05 | 7.48e-05 | 34 |
hsa0532331 | Breast | IDC | Rheumatoid arthritis | 21/867 | 93/8465 | 3.69e-04 | 3.15e-03 | 2.36e-03 | 21 |
hsa0512032 | Breast | IDC | Epithelial cell signaling in Helicobacter pylori infection | 16/867 | 70/8465 | 1.56e-03 | 1.13e-02 | 8.42e-03 | 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP6V0E1 | SNV | Missense_Mutation | novel | c.148N>T | p.Leu50Phe | p.L50F | O15342 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP6V0E1 | SNV | Missense_Mutation | c.10C>G | p.His4Asp | p.H4D | O15342 | protein_coding | tolerated(0.49) | benign(0.013) | TCGA-AO-A0JE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ATP6V0E1 | SNV | Missense_Mutation | novel | c.143N>A | p.Cys48Tyr | p.C48Y | O15342 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ATP6V0E1 | SNV | Missense_Mutation | c.16C>G | p.Leu6Val | p.L6V | O15342 | protein_coding | tolerated(0.09) | benign(0.139) | TCGA-EL-A3GS-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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