Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ARL6IP1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ARL6IP1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ARL6IP1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ARL6IP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/ARL6IP1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ARL6IP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ARL6IP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ARL6IP1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ARL6IP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ARL6IP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004586122 | Liver | HCC | negative regulation of proteolysis | 186/7958 | 351/18723 | 4.19e-05 | 4.11e-04 | 186 |
GO:005134622 | Liver | HCC | negative regulation of hydrolase activity | 195/7958 | 379/18723 | 2.44e-04 | 1.82e-03 | 195 |
GO:00066121 | Liver | HCC | protein targeting to membrane | 75/7958 | 131/18723 | 4.58e-04 | 3.04e-03 | 75 |
GO:00717862 | Liver | HCC | endoplasmic reticulum tubular network organization | 15/7958 | 18/18723 | 4.74e-04 | 3.12e-03 | 15 |
GO:001095121 | Liver | HCC | negative regulation of endopeptidase activity | 129/7958 | 252/18723 | 3.17e-03 | 1.47e-02 | 129 |
GO:001046621 | Liver | HCC | negative regulation of peptidase activity | 132/7958 | 262/18723 | 5.82e-03 | 2.42e-02 | 132 |
GO:00066131 | Liver | HCC | cotranslational protein targeting to membrane | 20/7958 | 31/18723 | 1.11e-02 | 4.09e-02 | 20 |
GO:0090158 | Liver | HCC | endoplasmic reticulum membrane organization | 10/7958 | 13/18723 | 1.28e-02 | 4.61e-02 | 10 |
GO:004586132 | Liver | Cyst | negative regulation of proteolysis | 25/496 | 351/18723 | 8.03e-06 | 5.72e-04 | 25 |
GO:00347672 | Liver | Cyst | positive regulation of ion transmembrane transport | 15/496 | 167/18723 | 3.95e-05 | 2.19e-03 | 15 |
GO:005254732 | Liver | Cyst | regulation of peptidase activity | 28/496 | 461/18723 | 4.37e-05 | 2.40e-03 | 28 |
GO:003476411 | Liver | Cyst | positive regulation of transmembrane transport | 17/496 | 219/18723 | 7.88e-05 | 3.78e-03 | 17 |
GO:009015021 | Liver | Cyst | establishment of protein localization to membrane | 18/496 | 260/18723 | 2.09e-04 | 7.84e-03 | 18 |
GO:005254832 | Liver | Cyst | regulation of endopeptidase activity | 25/496 | 432/18723 | 2.35e-04 | 8.42e-03 | 25 |
GO:000660522 | Liver | Cyst | protein targeting | 20/496 | 314/18723 | 2.88e-04 | 9.60e-03 | 20 |
GO:001046631 | Liver | Cyst | negative regulation of peptidase activity | 17/496 | 262/18723 | 6.53e-04 | 1.82e-02 | 17 |
GO:00432702 | Liver | Cyst | positive regulation of ion transport | 17/496 | 275/18723 | 1.12e-03 | 2.86e-02 | 17 |
GO:001095131 | Liver | Cyst | negative regulation of endopeptidase activity | 16/496 | 252/18723 | 1.17e-03 | 2.95e-02 | 16 |
GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
GO:200011620 | Oral cavity | OSCC | regulation of cysteine-type endopeptidase activity | 152/7305 | 235/18723 | 1.14e-15 | 8.13e-14 | 152 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL6IP1 | SNV | Missense_Mutation | novel | c.568G>A | p.Glu190Lys | p.E190K | Q15041 | protein_coding | tolerated(0.26) | benign(0.212) | TCGA-B6-A402-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PD |
ARL6IP1 | SNV | Missense_Mutation | | c.37N>C | p.Ala13Pro | p.A13P | Q15041 | protein_coding | tolerated(0.07) | possibly_damaging(0.806) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ARL6IP1 | insertion | In_Frame_Ins | novel | c.94_95insATACAGAAAAGGAAACTGGCAGATTTTCATTCACATTCATTT | p.Met32delinsAsnThrGluLysGluThrGlyArgPheSerPheThrPheIleLeu | p.M32delinsNTEKETGRFSFTFIL | Q15041 | protein_coding | | | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL6IP1 | SNV | Missense_Mutation | | c.374G>A | p.Arg125His | p.R125H | Q15041 | protein_coding | deleterious(0.04) | probably_damaging(0.959) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARL6IP1 | SNV | Missense_Mutation | | c.142N>T | p.Ile48Phe | p.I48F | Q15041 | protein_coding | tolerated(0.11) | benign(0.255) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
ARL6IP1 | SNV | Missense_Mutation | novel | c.517G>C | p.Gly173Arg | p.G173R | Q15041 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARL6IP1 | SNV | Missense_Mutation | | c.600N>T | p.Lys200Asn | p.K200N | Q15041 | protein_coding | deleterious(0.02) | possibly_damaging(0.829) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ARL6IP1 | SNV | Missense_Mutation | novel | c.22N>G | p.Ser8Gly | p.S8G | Q15041 | protein_coding | tolerated(0.22) | benign(0.049) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARL6IP1 | SNV | Missense_Mutation | rs748922543 | c.427N>A | p.Val143Ile | p.V143I | Q15041 | protein_coding | tolerated(1) | benign(0.005) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARL6IP1 | SNV | Missense_Mutation | | c.390N>T | p.Lys130Asn | p.K130N | Q15041 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |