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Gene: ARFIP1 |
Gene summary for ARFIP1 |
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Gene information | Species | Human | Gene symbol | ARFIP1 | Gene ID | 27236 |
Gene name | ADP ribosylation factor interacting protein 1 | |
Gene Alias | HSU52521 | |
Cytomap | 4q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B4E273 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27236 | ARFIP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.06e-21 | -6.84e-01 | 0.0155 |
27236 | ARFIP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.23e-06 | -5.73e-01 | -0.1207 |
27236 | ARFIP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.64e-06 | -4.15e-01 | -0.1464 |
27236 | ARFIP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.29e-03 | -3.46e-01 | -0.1001 |
27236 | ARFIP1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.91e-02 | -6.40e-01 | -0.1462 |
27236 | ARFIP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.48e-16 | -6.04e-01 | 0.096 |
27236 | ARFIP1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.20e-02 | -5.84e-01 | 0.0446 |
27236 | ARFIP1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.00e-04 | -6.66e-01 | 0.0528 |
27236 | ARFIP1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.25e-06 | -5.21e-01 | 0.0338 |
27236 | ARFIP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.08e-18 | -5.44e-01 | 0.0674 |
27236 | ARFIP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.78e-03 | -3.17e-01 | 0.294 |
27236 | ARFIP1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.36e-04 | -3.37e-01 | 0.281 |
27236 | ARFIP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.35e-05 | -3.81e-01 | 0.3859 |
27236 | ARFIP1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.23e-05 | -5.57e-01 | 0.2585 |
27236 | ARFIP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.43e-26 | -6.83e-01 | 0.3005 |
27236 | ARFIP1 | A015-C-203 | Human | Colorectum | FAP | 7.88e-29 | -3.04e-01 | -0.1294 |
27236 | ARFIP1 | A015-C-204 | Human | Colorectum | FAP | 7.76e-05 | -2.00e-01 | -0.0228 |
27236 | ARFIP1 | A014-C-040 | Human | Colorectum | FAP | 4.96e-03 | -2.65e-01 | -0.1184 |
27236 | ARFIP1 | A002-C-201 | Human | Colorectum | FAP | 2.11e-16 | -4.06e-01 | 0.0324 |
27236 | ARFIP1 | A002-C-203 | Human | Colorectum | FAP | 3.36e-05 | -3.76e-03 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00432544 | Colorectum | FAP | regulation of protein-containing complex assembly | 101/2622 | 428/18723 | 5.18e-08 | 4.07e-06 | 101 |
GO:19029034 | Colorectum | FAP | regulation of supramolecular fiber organization | 92/2622 | 383/18723 | 8.48e-08 | 5.77e-06 | 92 |
GO:00081544 | Colorectum | FAP | actin polymerization or depolymerization | 60/2622 | 218/18723 | 1.15e-07 | 7.43e-06 | 60 |
GO:00322714 | Colorectum | FAP | regulation of protein polymerization | 62/2622 | 233/18723 | 2.64e-07 | 1.53e-05 | 62 |
GO:19029054 | Colorectum | FAP | positive regulation of supramolecular fiber organization | 57/2622 | 209/18723 | 3.28e-07 | 1.83e-05 | 57 |
GO:00514954 | Colorectum | FAP | positive regulation of cytoskeleton organization | 60/2622 | 226/18723 | 4.45e-07 | 2.37e-05 | 60 |
GO:00300414 | Colorectum | FAP | actin filament polymerization | 53/2622 | 191/18723 | 4.65e-07 | 2.46e-05 | 53 |
GO:00313344 | Colorectum | FAP | positive regulation of protein-containing complex assembly | 62/2622 | 237/18723 | 5.03e-07 | 2.61e-05 | 62 |
GO:00308334 | Colorectum | FAP | regulation of actin filament polymerization | 49/2622 | 172/18723 | 5.32e-07 | 2.69e-05 | 49 |
GO:00080644 | Colorectum | FAP | regulation of actin polymerization or depolymerization | 52/2622 | 188/18723 | 6.62e-07 | 3.20e-05 | 52 |
GO:00512584 | Colorectum | FAP | protein polymerization | 73/2622 | 297/18723 | 7.11e-07 | 3.32e-05 | 73 |
GO:00308324 | Colorectum | FAP | regulation of actin filament length | 52/2622 | 189/18723 | 7.91e-07 | 3.64e-05 | 52 |
GO:00164823 | Colorectum | FAP | cytosolic transport | 47/2622 | 168/18723 | 1.58e-06 | 6.72e-05 | 47 |
GO:00507083 | Colorectum | FAP | regulation of protein secretion | 66/2622 | 268/18723 | 2.21e-06 | 8.87e-05 | 66 |
GO:00322734 | Colorectum | FAP | positive regulation of protein polymerization | 40/2622 | 138/18723 | 3.55e-06 | 1.26e-04 | 40 |
GO:00308384 | Colorectum | FAP | positive regulation of actin filament polymerization | 31/2622 | 99/18723 | 7.77e-06 | 2.32e-04 | 31 |
GO:00161973 | Colorectum | FAP | endosomal transport | 56/2622 | 230/18723 | 1.79e-05 | 4.53e-04 | 56 |
GO:00093063 | Colorectum | FAP | protein secretion | 79/2622 | 359/18723 | 2.24e-05 | 5.31e-04 | 79 |
GO:00323864 | Colorectum | FAP | regulation of intracellular transport | 75/2622 | 337/18723 | 2.38e-05 | 5.60e-04 | 75 |
GO:00355923 | Colorectum | FAP | establishment of protein localization to extracellular region | 79/2622 | 360/18723 | 2.48e-05 | 5.77e-04 | 79 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARFIP1 | SNV | Missense_Mutation | c.507G>C | p.Lys169Asn | p.K169N | P53367 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARFIP1 | SNV | Missense_Mutation | novel | c.76G>A | p.Glu26Lys | p.E26K | P53367 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.98) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARFIP1 | SNV | Missense_Mutation | novel | c.1097N>G | p.Ala366Gly | p.A366G | P53367 | protein_coding | tolerated(0.3) | benign(0.077) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARFIP1 | SNV | Missense_Mutation | rs146931969 | c.1004N>G | p.Asn335Ser | p.N335S | P53367 | protein_coding | tolerated(0.07) | benign(0) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARFIP1 | SNV | Missense_Mutation | c.923N>A | p.Arg308His | p.R308H | P53367 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3975-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARFIP1 | SNV | Missense_Mutation | rs776711621 | c.811N>T | p.Arg271Cys | p.R271C | P53367 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ARFIP1 | SNV | Missense_Mutation | novel | c.1024N>A | p.Ala342Thr | p.A342T | P53367 | protein_coding | tolerated(0.1) | probably_damaging(0.96) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARFIP1 | SNV | Missense_Mutation | novel | c.572N>G | p.His191Arg | p.H191R | P53367 | protein_coding | deleterious(0.03) | benign(0.084) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARFIP1 | SNV | Missense_Mutation | c.302G>A | p.Gly101Asp | p.G101D | P53367 | protein_coding | tolerated(0.45) | benign(0) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ARFIP1 | SNV | Missense_Mutation | c.452N>T | p.Ser151Leu | p.S151L | P53367 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-D5-6532-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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