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Gene: AKT1S1 |
Gene summary for AKT1S1 |
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Gene information | Species | Human | Gene symbol | AKT1S1 | Gene ID | 84335 |
Gene name | AKT1 substrate 1 | |
Gene Alias | Lobe | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | A0A024QZF6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84335 | AKT1S1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.29e-05 | 1.33e-01 | 0.0155 |
84335 | AKT1S1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.03e-06 | 2.24e-01 | -0.1808 |
84335 | AKT1S1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.43e-08 | 2.43e-01 | -0.0811 |
84335 | AKT1S1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.84e-03 | 1.45e-01 | -0.1088 |
84335 | AKT1S1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.93e-13 | 2.74e-01 | -0.1954 |
84335 | AKT1S1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.90e-02 | 2.44e-01 | -0.2196 |
84335 | AKT1S1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.34e-03 | 1.69e-01 | -0.1207 |
84335 | AKT1S1 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.35e-06 | 2.31e-01 | -0.1526 |
84335 | AKT1S1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.32e-10 | 2.13e-01 | -0.1464 |
84335 | AKT1S1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.25e-05 | 1.27e-01 | -0.1001 |
84335 | AKT1S1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.72e-12 | 2.80e-01 | -0.059 |
84335 | AKT1S1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.29e-03 | 2.14e-01 | -0.1706 |
84335 | AKT1S1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.32e-06 | 1.89e-01 | 0.096 |
84335 | AKT1S1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.81e-04 | 2.58e-01 | 0.0131 |
84335 | AKT1S1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.36e-03 | 1.87e-01 | -0.0177 |
84335 | AKT1S1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.64e-05 | 3.00e-01 | 0.0171 |
84335 | AKT1S1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.64e-04 | 1.64e-01 | 0.0338 |
84335 | AKT1S1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.19e-14 | 2.65e-01 | 0.0674 |
84335 | AKT1S1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.25e-06 | 2.38e-01 | 0.0112 |
84335 | AKT1S1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.45e-04 | 3.33e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045936110 | Oral cavity | LP | negative regulation of phosphate metabolic process | 152/4623 | 441/18723 | 2.10e-06 | 4.77e-05 | 152 |
GO:1901214110 | Oral cavity | LP | regulation of neuron death | 115/4623 | 319/18723 | 3.39e-06 | 7.19e-05 | 115 |
GO:005140218 | Oral cavity | LP | neuron apoptotic process | 91/4623 | 246/18723 | 1.07e-05 | 1.94e-04 | 91 |
GO:0042326110 | Oral cavity | LP | negative regulation of phosphorylation | 131/4623 | 385/18723 | 2.10e-05 | 3.46e-04 | 131 |
GO:003367318 | Oral cavity | LP | negative regulation of kinase activity | 86/4623 | 237/18723 | 4.19e-05 | 6.07e-04 | 86 |
GO:0001933110 | Oral cavity | LP | negative regulation of protein phosphorylation | 117/4623 | 342/18723 | 4.34e-05 | 6.22e-04 | 117 |
GO:000646919 | Oral cavity | LP | negative regulation of protein kinase activity | 78/4623 | 212/18723 | 5.45e-05 | 7.55e-04 | 78 |
GO:0032535110 | Oral cavity | LP | regulation of cellular component size | 128/4623 | 383/18723 | 6.56e-05 | 8.80e-04 | 128 |
GO:004352316 | Oral cavity | LP | regulation of neuron apoptotic process | 73/4623 | 212/18723 | 8.87e-04 | 7.64e-03 | 73 |
GO:004593628 | Skin | cSCC | negative regulation of phosphate metabolic process | 160/4864 | 441/18723 | 8.89e-07 | 1.63e-05 | 160 |
GO:001056328 | Skin | cSCC | negative regulation of phosphorus metabolic process | 160/4864 | 442/18723 | 1.04e-06 | 1.85e-05 | 160 |
GO:007099729 | Skin | cSCC | neuron death | 133/4864 | 361/18723 | 2.91e-06 | 4.58e-05 | 133 |
GO:004232626 | Skin | cSCC | negative regulation of phosphorylation | 137/4864 | 385/18723 | 1.63e-05 | 1.99e-04 | 137 |
GO:000193326 | Skin | cSCC | negative regulation of protein phosphorylation | 123/4864 | 342/18723 | 2.48e-05 | 2.82e-04 | 123 |
GO:005134829 | Skin | cSCC | negative regulation of transferase activity | 100/4864 | 268/18723 | 2.60e-05 | 2.94e-04 | 100 |
GO:190121426 | Skin | cSCC | regulation of neuron death | 112/4864 | 319/18723 | 1.71e-04 | 1.48e-03 | 112 |
GO:0032535111 | Skin | cSCC | regulation of cellular component size | 131/4864 | 383/18723 | 1.89e-04 | 1.59e-03 | 131 |
GO:005140225 | Skin | cSCC | neuron apoptotic process | 88/4864 | 246/18723 | 4.04e-04 | 3.16e-03 | 88 |
GO:0006469110 | Skin | cSCC | negative regulation of protein kinase activity | 74/4864 | 212/18723 | 2.36e-03 | 1.37e-02 | 74 |
GO:0033673110 | Skin | cSCC | negative regulation of kinase activity | 81/4864 | 237/18723 | 2.95e-03 | 1.64e-02 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04213 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa04211 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa042131 | Colorectum | AD | Longevity regulating pathway - multiple species | 27/2092 | 62/8465 | 8.72e-04 | 5.96e-03 | 3.80e-03 | 27 |
hsa042111 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa042132 | Colorectum | SER | Longevity regulating pathway - multiple species | 20/1580 | 62/8465 | 7.15e-03 | 3.77e-02 | 2.74e-02 | 20 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa042133 | Colorectum | SER | Longevity regulating pathway - multiple species | 20/1580 | 62/8465 | 7.15e-03 | 3.77e-02 | 2.74e-02 | 20 |
hsa047144 | Colorectum | MSS | Thermogenesis | 113/1875 | 232/8465 | 1.52e-19 | 4.62e-18 | 2.83e-18 | 113 |
hsa051314 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKT1S1 | SNV | Missense_Mutation | novel | c.668N>T | p.Ser223Leu | p.S223L | Q96B36 | protein_coding | tolerated(0.09) | probably_damaging(0.978) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AKT1S1 | SNV | Missense_Mutation | c.305N>A | p.Pro102Gln | p.P102Q | Q96B36 | protein_coding | tolerated(0.42) | possibly_damaging(0.881) | TCGA-FU-A57G-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
AKT1S1 | SNV | Missense_Mutation | rs374227857 | c.661N>T | p.Arg221Trp | p.R221W | Q96B36 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AKT1S1 | SNV | Missense_Mutation | novel | c.548G>C | p.Gly183Ala | p.G183A | Q96B36 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AKT1S1 | SNV | Missense_Mutation | c.337N>A | p.Pro113Thr | p.P113T | Q96B36 | protein_coding | tolerated(0.13) | benign(0.06) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AKT1S1 | SNV | Missense_Mutation | rs375398248 | c.233C>T | p.Ala78Val | p.A78V | Q96B36 | protein_coding | tolerated(0.22) | benign(0.14) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AKT1S1 | SNV | Missense_Mutation | rs142575650 | c.659N>T | p.Ala220Val | p.A220V | Q96B36 | protein_coding | tolerated(0.15) | benign(0.086) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
AKT1S1 | SNV | Missense_Mutation | novel | c.335N>T | p.Ser112Ile | p.S112I | Q96B36 | protein_coding | deleterious(0.01) | possibly_damaging(0.737) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
AKT1S1 | SNV | Missense_Mutation | novel | c.474N>T | p.Gln158His | p.Q158H | Q96B36 | protein_coding | deleterious(0.03) | possibly_damaging(0.555) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AKT1S1 | SNV | Missense_Mutation | novel | c.221T>C | p.Leu74Pro | p.L74P | Q96B36 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
84335 | AKT1S1 | KINASE, DRUGGABLE GENOME | GEDATOLISIB | GEDATOLISIB | 20166697 | |
84335 | AKT1S1 | KINASE, DRUGGABLE GENOME | inhibitor | OSI-027 | OSI-027 | |
84335 | AKT1S1 | KINASE, DRUGGABLE GENOME | inhibitor | AZD8055 | AZD-8055 | |
84335 | AKT1S1 | KINASE, DRUGGABLE GENOME | inhibitor | MLN0128 | SAPANISERTIB |
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