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Gene: AKAP8 |
Gene summary for AKAP8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | AKAP8 | Gene ID | 10270 |
| Gene name | A-kinase anchoring protein 8 | |
| Gene Alias | AKAP 95 | |
| Cytomap | 19p13.12 | |
| Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | O43823 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10270 | AKAP8 | LZE4T | Human | Esophagus | ESCC | 7.61e-03 | 7.80e-02 | 0.0811 |
| 10270 | AKAP8 | LZE7T | Human | Esophagus | ESCC | 1.43e-05 | 2.56e-01 | 0.0667 |
| 10270 | AKAP8 | LZE22T | Human | Esophagus | ESCC | 3.07e-03 | 2.14e-01 | 0.068 |
| 10270 | AKAP8 | LZE24T | Human | Esophagus | ESCC | 1.21e-08 | 2.23e-01 | 0.0596 |
| 10270 | AKAP8 | LZE21T | Human | Esophagus | ESCC | 1.52e-03 | 1.36e-01 | 0.0655 |
| 10270 | AKAP8 | P1T-E | Human | Esophagus | ESCC | 1.34e-06 | 4.00e-01 | 0.0875 |
| 10270 | AKAP8 | P2T-E | Human | Esophagus | ESCC | 2.17e-11 | 2.47e-01 | 0.1177 |
| 10270 | AKAP8 | P4T-E | Human | Esophagus | ESCC | 2.51e-19 | 3.59e-01 | 0.1323 |
| 10270 | AKAP8 | P5T-E | Human | Esophagus | ESCC | 4.74e-16 | 2.11e-01 | 0.1327 |
| 10270 | AKAP8 | P8T-E | Human | Esophagus | ESCC | 1.70e-15 | 3.06e-01 | 0.0889 |
| 10270 | AKAP8 | P9T-E | Human | Esophagus | ESCC | 7.68e-11 | 2.32e-01 | 0.1131 |
| 10270 | AKAP8 | P10T-E | Human | Esophagus | ESCC | 1.59e-13 | 2.72e-01 | 0.116 |
| 10270 | AKAP8 | P11T-E | Human | Esophagus | ESCC | 3.59e-11 | 3.96e-01 | 0.1426 |
| 10270 | AKAP8 | P12T-E | Human | Esophagus | ESCC | 1.85e-17 | 3.48e-01 | 0.1122 |
| 10270 | AKAP8 | P15T-E | Human | Esophagus | ESCC | 7.15e-13 | 2.96e-01 | 0.1149 |
| 10270 | AKAP8 | P16T-E | Human | Esophagus | ESCC | 1.18e-07 | 1.58e-01 | 0.1153 |
| 10270 | AKAP8 | P19T-E | Human | Esophagus | ESCC | 1.77e-08 | 3.11e-01 | 0.1662 |
| 10270 | AKAP8 | P20T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.53e-01 | 0.1124 |
| 10270 | AKAP8 | P21T-E | Human | Esophagus | ESCC | 3.72e-16 | 3.57e-01 | 0.1617 |
| 10270 | AKAP8 | P22T-E | Human | Esophagus | ESCC | 2.71e-11 | 9.93e-02 | 0.1236 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0007059 | Liver | HCC | chromosome segregation | 197/7958 | 346/18723 | 3.57e-08 | 7.87e-07 | 197 |
| GO:00064051 | Liver | HCC | RNA export from nucleus | 60/7958 | 84/18723 | 7.28e-08 | 1.48e-06 | 60 |
| GO:00064061 | Liver | HCC | mRNA export from nucleus | 44/7958 | 59/18723 | 5.61e-07 | 8.98e-06 | 44 |
| GO:00714271 | Liver | HCC | mRNA-containing ribonucleoprotein complex export from nucleus | 44/7958 | 59/18723 | 5.61e-07 | 8.98e-06 | 44 |
| GO:00315031 | Liver | HCC | protein-containing complex localization | 129/7958 | 220/18723 | 9.38e-07 | 1.42e-05 | 129 |
| GO:0098813 | Liver | HCC | nuclear chromosome segregation | 157/7958 | 281/18723 | 3.82e-06 | 4.95e-05 | 157 |
| GO:00717631 | Liver | HCC | nuclear membrane organization | 27/7958 | 33/18723 | 4.31e-06 | 5.50e-05 | 27 |
| GO:00069971 | Liver | HCC | nucleus organization | 82/7958 | 133/18723 | 6.32e-06 | 7.72e-05 | 82 |
| GO:0048285 | Liver | HCC | organelle fission | 254/7958 | 488/18723 | 1.07e-05 | 1.23e-04 | 254 |
| GO:0006998 | Liver | HCC | nuclear envelope organization | 34/7958 | 47/18723 | 3.27e-05 | 3.29e-04 | 34 |
| GO:0031058 | Liver | HCC | positive regulation of histone modification | 58/7958 | 92/18723 | 5.55e-05 | 5.21e-04 | 58 |
| GO:00468312 | Liver | HCC | regulation of RNA export from nucleus | 11/7958 | 12/18723 | 5.97e-04 | 3.75e-03 | 11 |
| GO:0098732 | Liver | HCC | macromolecule deacylation | 67/7958 | 116/18723 | 6.46e-04 | 3.99e-03 | 67 |
| GO:0000280 | Liver | HCC | nuclear division | 220/7958 | 439/18723 | 6.90e-04 | 4.25e-03 | 220 |
| GO:00356011 | Liver | HCC | protein deacylation | 64/7958 | 112/18723 | 1.23e-03 | 6.83e-03 | 64 |
| GO:0090311 | Liver | HCC | regulation of protein deacetylation | 30/7958 | 48/18723 | 4.10e-03 | 1.78e-02 | 30 |
| GO:0044839 | Liver | HCC | cell cycle G2/M phase transition | 79/7958 | 148/18723 | 4.82e-03 | 2.03e-02 | 79 |
| GO:00064761 | Liver | HCC | protein deacetylation | 55/7958 | 101/18723 | 1.01e-02 | 3.79e-02 | 55 |
| GO:00165704 | Lung | IAC | histone modification | 93/2061 | 463/18723 | 5.41e-09 | 8.03e-07 | 93 |
| GO:00069138 | Lung | IAC | nucleocytoplasmic transport | 63/2061 | 301/18723 | 3.50e-07 | 2.54e-05 | 63 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| AKAP8 | SNV | Missense_Mutation | rs764482753 | c.1192N>T | p.Arg398Cys | p.R398C | O43823 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| AKAP8 | SNV | Missense_Mutation | novel | c.1489C>T | p.Arg497Trp | p.R497W | O43823 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
| AKAP8 | SNV | Missense_Mutation | rs767177827 | c.1268C>G | p.Thr423Ser | p.T423S | O43823 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| AKAP8 | SNV | Missense_Mutation | c.1600A>C | p.Lys534Gln | p.K534Q | O43823 | protein_coding | deleterious(0.02) | probably_damaging(0.939) | TCGA-E2-A1L7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | |
| AKAP8 | SNV | Missense_Mutation | novel | c.1997N>C | p.Arg666Thr | p.R666T | O43823 | protein_coding | tolerated_low_confidence(0.6) | benign(0.005) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
| AKAP8 | SNV | Missense_Mutation | c.1581N>C | p.Leu527Phe | p.L527F | O43823 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| AKAP8 | SNV | Missense_Mutation | c.374C>T | p.Ser125Phe | p.S125F | O43823 | protein_coding | deleterious(0.05) | benign(0.072) | TCGA-EK-A3GN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| AKAP8 | SNV | Missense_Mutation | novel | c.1015T>G | p.Ser339Ala | p.S339A | O43823 | protein_coding | tolerated(0.09) | possibly_damaging(0.565) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| AKAP8 | SNV | Missense_Mutation | c.712N>T | p.Pro238Ser | p.P238S | O43823 | protein_coding | tolerated(0.08) | benign(0.062) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| AKAP8 | SNV | Missense_Mutation | c.2006N>T | p.Pro669Leu | p.P669L | O43823 | protein_coding | tolerated_low_confidence(0.3) | benign(0) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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