Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ADAMTS9_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ADAMTS9_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ADAMTS9_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ADAMTS9_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158916 | Prostate | Tumor | cell-substrate adhesion | 109/3246 | 363/18723 | 1.41e-09 | 6.71e-08 | 109 |
GO:009013217 | Prostate | Tumor | epithelium migration | 105/3246 | 360/18723 | 1.57e-08 | 5.62e-07 | 105 |
GO:009013017 | Prostate | Tumor | tissue migration | 106/3246 | 365/18723 | 1.73e-08 | 6.10e-07 | 106 |
GO:001063117 | Prostate | Tumor | epithelial cell migration | 104/3246 | 357/18723 | 1.97e-08 | 6.91e-07 | 104 |
GO:000166718 | Prostate | Tumor | ameboidal-type cell migration | 130/3246 | 475/18723 | 2.36e-08 | 8.09e-07 | 130 |
GO:001063217 | Prostate | Tumor | regulation of epithelial cell migration | 85/3246 | 292/18723 | 3.91e-07 | 8.63e-06 | 85 |
GO:000716015 | Prostate | Tumor | cell-matrix adhesion | 71/3246 | 233/18723 | 5.40e-07 | 1.16e-05 | 71 |
GO:006053714 | Prostate | Tumor | muscle tissue development | 107/3246 | 403/18723 | 1.93e-06 | 3.34e-05 | 107 |
GO:004354214 | Prostate | Tumor | endothelial cell migration | 76/3246 | 279/18723 | 2.19e-05 | 2.80e-04 | 76 |
GO:001470613 | Prostate | Tumor | striated muscle tissue development | 98/3246 | 384/18723 | 2.96e-05 | 3.56e-04 | 98 |
GO:005127114 | Prostate | Tumor | negative regulation of cellular component movement | 92/3246 | 367/18723 | 1.03e-04 | 9.99e-04 | 92 |
GO:00031701 | Prostate | Tumor | heart valve development | 24/3246 | 65/18723 | 1.28e-04 | 1.19e-03 | 24 |
GO:200014614 | Prostate | Tumor | negative regulation of cell motility | 89/3246 | 359/18723 | 1.99e-04 | 1.74e-03 | 89 |
GO:001059413 | Prostate | Tumor | regulation of endothelial cell migration | 61/3246 | 232/18723 | 3.81e-04 | 2.96e-03 | 61 |
GO:004001313 | Prostate | Tumor | negative regulation of locomotion | 94/3246 | 391/18723 | 4.20e-04 | 3.21e-03 | 94 |
GO:003033613 | Prostate | Tumor | negative regulation of cell migration | 84/3246 | 344/18723 | 4.95e-04 | 3.66e-03 | 84 |
GO:00031791 | Prostate | Tumor | heart valve morphogenesis | 20/3246 | 55/18723 | 5.74e-04 | 4.13e-03 | 20 |
GO:00487382 | Prostate | Tumor | cardiac muscle tissue development | 57/3246 | 236/18723 | 4.67e-03 | 2.29e-02 | 57 |
GO:190134212 | Prostate | Tumor | regulation of vasculature development | 79/3246 | 348/18723 | 5.84e-03 | 2.71e-02 | 79 |
GO:004576512 | Prostate | Tumor | regulation of angiogenesis | 77/3246 | 342/18723 | 7.92e-03 | 3.52e-02 | 77 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS9 | SNV | Missense_Mutation | | c.1226N>A | p.Gly409Glu | p.G409E | Q9P2N4 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAMTS9 | SNV | Missense_Mutation | | c.5698N>C | p.Ser1900Pro | p.S1900P | Q9P2N4 | protein_coding | tolerated(0.13) | possibly_damaging(0.718) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
ADAMTS9 | SNV | Missense_Mutation | novel | c.2728N>G | p.Gln910Glu | p.Q910E | Q9P2N4 | protein_coding | tolerated(0.07) | benign(0.096) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
ADAMTS9 | SNV | Missense_Mutation | | c.3422N>T | p.Ser1141Leu | p.S1141L | Q9P2N4 | protein_coding | tolerated(0.1) | benign(0.044) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ADAMTS9 | SNV | Missense_Mutation | rs775861579 | c.4717N>A | p.Glu1573Lys | p.E1573K | Q9P2N4 | protein_coding | tolerated(0.94) | benign(0.044) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
ADAMTS9 | SNV | Missense_Mutation | rs749861523 | c.4837N>A | p.Glu1613Lys | p.E1613K | Q9P2N4 | protein_coding | tolerated(0.87) | benign(0.007) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADAMTS9 | SNV | Missense_Mutation | novel | c.5272A>G | p.Ile1758Val | p.I1758V | Q9P2N4 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AO-A1KT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
ADAMTS9 | SNV | Missense_Mutation | | c.4658G>A | p.Arg1553Gln | p.R1553Q | Q9P2N4 | protein_coding | tolerated(0.29) | benign(0) | TCGA-B6-A408-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
ADAMTS9 | SNV | Missense_Mutation | | c.4495C>T | p.Pro1499Ser | p.P1499S | Q9P2N4 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ADAMTS9 | SNV | Missense_Mutation | | c.2533N>T | p.Ile845Phe | p.I845F | Q9P2N4 | protein_coding | deleterious(0.01) | probably_damaging(0.914) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |