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Gene: RDX |
Gene summary for RDX |
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Gene information | Species | Human | Gene symbol | RDX | Gene ID | 5962 |
Gene name | radixin | |
Gene Alias | DFNB24 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | P35241 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5962 | RDX | LZE4T | Human | Esophagus | ESCC | 5.86e-15 | 4.55e-01 | 0.0811 |
5962 | RDX | LZE8T | Human | Esophagus | ESCC | 1.79e-07 | 1.06e-02 | 0.067 |
5962 | RDX | LZE20T | Human | Esophagus | ESCC | 1.81e-08 | 2.12e-01 | 0.0662 |
5962 | RDX | LZE24T | Human | Esophagus | ESCC | 8.62e-11 | 4.75e-01 | 0.0596 |
5962 | RDX | LZE6T | Human | Esophagus | ESCC | 4.29e-03 | -4.53e-02 | 0.0845 |
5962 | RDX | P1T-E | Human | Esophagus | ESCC | 1.88e-09 | 3.22e-01 | 0.0875 |
5962 | RDX | P2T-E | Human | Esophagus | ESCC | 1.70e-18 | 3.60e-01 | 0.1177 |
5962 | RDX | P4T-E | Human | Esophagus | ESCC | 1.40e-40 | 1.07e+00 | 0.1323 |
5962 | RDX | P5T-E | Human | Esophagus | ESCC | 9.33e-54 | 1.18e+00 | 0.1327 |
5962 | RDX | P8T-E | Human | Esophagus | ESCC | 1.00e-10 | 2.93e-01 | 0.0889 |
5962 | RDX | P9T-E | Human | Esophagus | ESCC | 6.81e-19 | 6.70e-01 | 0.1131 |
5962 | RDX | P10T-E | Human | Esophagus | ESCC | 1.38e-45 | 1.08e+00 | 0.116 |
5962 | RDX | P11T-E | Human | Esophagus | ESCC | 1.70e-27 | 1.43e+00 | 0.1426 |
5962 | RDX | P12T-E | Human | Esophagus | ESCC | 3.07e-38 | 9.01e-01 | 0.1122 |
5962 | RDX | P15T-E | Human | Esophagus | ESCC | 1.16e-15 | 4.37e-01 | 0.1149 |
5962 | RDX | P16T-E | Human | Esophagus | ESCC | 3.08e-22 | 4.33e-01 | 0.1153 |
5962 | RDX | P17T-E | Human | Esophagus | ESCC | 1.86e-05 | 6.31e-01 | 0.1278 |
5962 | RDX | P19T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.30e+00 | 0.1662 |
5962 | RDX | P20T-E | Human | Esophagus | ESCC | 1.17e-20 | 5.52e-01 | 0.1124 |
5962 | RDX | P21T-E | Human | Esophagus | ESCC | 1.49e-49 | 1.16e+00 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:004573222 | Liver | HCC | positive regulation of protein catabolic process | 163/7958 | 231/18723 | 4.00e-18 | 4.69e-16 | 163 |
GO:004348422 | Liver | HCC | regulation of RNA splicing | 113/7958 | 148/18723 | 4.32e-17 | 4.15e-15 | 113 |
GO:005068421 | Liver | HCC | regulation of mRNA processing | 106/7958 | 137/18723 | 7.64e-17 | 7.12e-15 | 106 |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
GO:190336422 | Liver | HCC | positive regulation of cellular protein catabolic process | 115/7958 | 155/18723 | 9.30e-16 | 7.19e-14 | 115 |
GO:003459922 | Liver | HCC | cellular response to oxidative stress | 183/7958 | 288/18723 | 3.65e-13 | 1.93e-11 | 183 |
GO:001648221 | Liver | HCC | cytosolic transport | 117/7958 | 168/18723 | 8.83e-13 | 4.48e-11 | 117 |
GO:001056322 | Liver | HCC | negative regulation of phosphorus metabolic process | 259/7958 | 442/18723 | 4.29e-12 | 1.92e-10 | 259 |
GO:004593622 | Liver | HCC | negative regulation of phosphate metabolic process | 258/7958 | 441/18723 | 6.00e-12 | 2.60e-10 | 258 |
GO:009719122 | Liver | HCC | extrinsic apoptotic signaling pathway | 143/7958 | 219/18723 | 6.99e-12 | 2.97e-10 | 143 |
GO:007265921 | Liver | HCC | protein localization to plasma membrane | 177/7958 | 284/18723 | 1.02e-11 | 4.18e-10 | 177 |
GO:000030222 | Liver | HCC | response to reactive oxygen species | 144/7958 | 222/18723 | 1.24e-11 | 5.09e-10 | 144 |
GO:200123412 | Liver | HCC | negative regulation of apoptotic signaling pathway | 145/7958 | 224/18723 | 1.33e-11 | 5.36e-10 | 145 |
GO:004232622 | Liver | HCC | negative regulation of phosphorylation | 227/7958 | 385/18723 | 3.98e-11 | 1.52e-09 | 227 |
GO:005125822 | Liver | HCC | protein polymerization | 182/7958 | 297/18723 | 4.17e-11 | 1.58e-09 | 182 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:199077821 | Liver | HCC | protein localization to cell periphery | 200/7958 | 333/18723 | 6.07e-11 | 2.23e-09 | 200 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa04530211 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0481028 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa0520537 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa04530310 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa04810112 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa0453022 | Liver | Cirrhotic | Tight junction | 82/2530 | 169/8465 | 2.14e-07 | 2.85e-06 | 1.76e-06 | 82 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0520510 | Liver | Cirrhotic | Proteoglycans in cancer | 85/2530 | 205/8465 | 2.37e-04 | 1.58e-03 | 9.75e-04 | 85 |
hsa0453032 | Liver | Cirrhotic | Tight junction | 82/2530 | 169/8465 | 2.14e-07 | 2.85e-06 | 1.76e-06 | 82 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0520511 | Liver | Cirrhotic | Proteoglycans in cancer | 85/2530 | 205/8465 | 2.37e-04 | 1.58e-03 | 9.75e-04 | 85 |
hsa0453042 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0520521 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0453052 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0520531 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0520526 | Oral cavity | OSCC | Proteoglycans in cancer | 128/3704 | 205/8465 | 4.00e-08 | 3.12e-07 | 1.59e-07 | 128 |
hsa0453030 | Oral cavity | OSCC | Tight junction | 102/3704 | 169/8465 | 8.68e-06 | 3.93e-05 | 2.00e-05 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RDX | SNV | Missense_Mutation | c.252C>G | p.Phe84Leu | p.F84L | P35241 | protein_coding | deleterious(0.01) | benign(0.224) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RDX | SNV | Missense_Mutation | c.1403N>T | p.Ser468Phe | p.S468F | P35241 | protein_coding | deleterious(0.03) | benign(0.409) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
RDX | SNV | Missense_Mutation | c.1495N>C | p.Glu499Gln | p.E499Q | P35241 | protein_coding | deleterious(0.02) | probably_damaging(0.932) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RDX | SNV | Missense_Mutation | c.344N>C | p.Ile115Thr | p.I115T | P35241 | protein_coding | deleterious(0) | possibly_damaging(0.693) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
RDX | SNV | Missense_Mutation | c.733A>T | p.Ile245Phe | p.I245F | P35241 | protein_coding | deleterious(0.02) | probably_damaging(0.936) | TCGA-S3-AA11-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | CR | |
RDX | insertion | Frame_Shift_Ins | novel | c.639_640insTCTCATTTGATAAATAC | p.Thr214SerfsTer11 | p.T214Sfs*11 | P35241 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
RDX | insertion | Frame_Shift_Ins | novel | c.583_584insACATAACT | p.Ala195AspfsTer7 | p.A195Dfs*7 | P35241 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RDX | insertion | In_Frame_Ins | novel | c.582_583insAAGTTACTA | p.Ile194_Ala195insLysLeuLeu | p.I194_A195insKLL | P35241 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RDX | SNV | Missense_Mutation | rs780179741 | c.1706N>A | p.Arg569Gln | p.R569Q | P35241 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RDX | SNV | Missense_Mutation | novel | c.1369N>A | p.Glu457Lys | p.E457K | P35241 | protein_coding | tolerated(0.46) | possibly_damaging(0.832) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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