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Gene: LRP1 |
Gene summary for LRP1 |
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Gene information | Species | Human | Gene symbol | LRP1 | Gene ID | 4035 |
Gene name | LDL receptor related protein 1 | |
Gene Alias | A2MR | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q07954 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4035 | LRP1 | CA_HPV_3 | Human | Cervix | CC | 1.24e-03 | -1.44e-02 | 0.0414 |
4035 | LRP1 | CCI_1 | Human | Cervix | CC | 2.83e-03 | 9.08e-01 | 0.528 |
4035 | LRP1 | CCI_3 | Human | Cervix | CC | 7.50e-20 | 1.34e+00 | 0.516 |
4035 | LRP1 | sample3 | Human | Cervix | CC | 7.98e-24 | 4.17e-01 | 0.1387 |
4035 | LRP1 | T3 | Human | Cervix | CC | 1.68e-13 | 4.17e-01 | 0.1389 |
4035 | LRP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.12e-03 | 3.26e-01 | -0.1808 |
4035 | LRP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.69e-05 | 3.99e-01 | -0.0811 |
4035 | LRP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.82e-09 | 4.38e-01 | -0.1954 |
4035 | LRP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.93e-05 | 7.58e-01 | -0.2602 |
4035 | LRP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.40e-03 | 3.21e-01 | -0.1207 |
4035 | LRP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.14e-15 | 5.67e-01 | -0.1464 |
4035 | LRP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.86e-16 | 5.03e-01 | -0.1001 |
4035 | LRP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.71e-09 | 5.78e-01 | -0.059 |
4035 | LRP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.78e-06 | 5.47e-01 | -0.0842 |
4035 | LRP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.76e-10 | 4.06e-01 | 0.096 |
4035 | LRP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.26e-06 | 3.56e-01 | 0.0674 |
4035 | LRP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.52e-10 | 5.27e-01 | 0.3859 |
4035 | LRP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.16e-05 | 3.15e-01 | 0.3005 |
4035 | LRP1 | A015-C-203 | Human | Colorectum | FAP | 1.69e-03 | 4.88e-02 | -0.1294 |
4035 | LRP1 | A002-C-021 | Human | Colorectum | FAP | 3.69e-03 | 2.68e-01 | 0.1171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00303079 | Oral cavity | OSCC | positive regulation of cell growth | 92/7305 | 166/18723 | 1.27e-05 | 1.29e-04 | 92 |
GO:005189316 | Oral cavity | OSCC | regulation of focal adhesion assembly | 43/7305 | 66/18723 | 1.52e-05 | 1.52e-04 | 43 |
GO:009010916 | Oral cavity | OSCC | regulation of cell-substrate junction assembly | 43/7305 | 66/18723 | 1.52e-05 | 1.52e-04 | 43 |
GO:00421572 | Oral cavity | OSCC | lipoprotein metabolic process | 77/7305 | 135/18723 | 1.61e-05 | 1.60e-04 | 77 |
GO:003011110 | Oral cavity | OSCC | regulation of Wnt signaling pathway | 165/7305 | 328/18723 | 1.87e-05 | 1.80e-04 | 165 |
GO:003134610 | Oral cavity | OSCC | positive regulation of cell projection organization | 176/7305 | 353/18723 | 1.94e-05 | 1.87e-04 | 176 |
GO:015011617 | Oral cavity | OSCC | regulation of cell-substrate junction organization | 45/7305 | 71/18723 | 2.76e-05 | 2.56e-04 | 45 |
GO:004580710 | Oral cavity | OSCC | positive regulation of endocytosis | 59/7305 | 100/18723 | 3.99e-05 | 3.48e-04 | 59 |
GO:00507679 | Oral cavity | OSCC | regulation of neurogenesis | 179/7305 | 364/18723 | 4.49e-05 | 3.84e-04 | 179 |
GO:004352310 | Oral cavity | OSCC | regulation of neuron apoptotic process | 111/7305 | 212/18723 | 5.12e-05 | 4.27e-04 | 111 |
GO:000689810 | Oral cavity | OSCC | receptor-mediated endocytosis | 125/7305 | 244/18723 | 6.56e-05 | 5.32e-04 | 125 |
GO:190437716 | Oral cavity | OSCC | positive regulation of protein localization to cell periphery | 43/7305 | 69/18723 | 7.43e-05 | 5.81e-04 | 43 |
GO:000974320 | Oral cavity | OSCC | response to carbohydrate | 128/7305 | 253/18723 | 1.11e-04 | 8.16e-04 | 128 |
GO:00069196 | Oral cavity | OSCC | activation of cysteine-type endopeptidase activity involved in apoptotic process | 47/7305 | 78/18723 | 1.16e-04 | 8.42e-04 | 47 |
GO:190307815 | Oral cavity | OSCC | positive regulation of protein localization to plasma membrane | 39/7305 | 62/18723 | 1.19e-04 | 8.54e-04 | 39 |
GO:0051259 | Oral cavity | OSCC | protein complex oligomerization | 121/7305 | 238/18723 | 1.29e-04 | 9.21e-04 | 121 |
GO:004311210 | Oral cavity | OSCC | receptor metabolic process | 88/7305 | 166/18723 | 1.68e-04 | 1.15e-03 | 88 |
GO:00321037 | Oral cavity | OSCC | positive regulation of response to external stimulus | 203/7305 | 427/18723 | 1.79e-04 | 1.22e-03 | 203 |
GO:005134618 | Oral cavity | OSCC | negative regulation of hydrolase activity | 182/7305 | 379/18723 | 1.98e-04 | 1.32e-03 | 182 |
GO:0140374 | Oral cavity | OSCC | antiviral innate immune response | 13/7305 | 15/18723 | 2.07e-04 | 1.36e-03 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050104 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa050105 | Colorectum | MSS | Alzheimer disease | 169/1875 | 384/8465 | 1.21e-22 | 1.01e-20 | 6.21e-21 | 169 |
hsa050108 | Colorectum | FAP | Alzheimer disease | 105/1404 | 384/8465 | 3.74e-08 | 1.04e-06 | 6.33e-07 | 105 |
hsa050109 | Colorectum | FAP | Alzheimer disease | 105/1404 | 384/8465 | 3.74e-08 | 1.04e-06 | 6.33e-07 | 105 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa049796 | Liver | NAFLD | Cholesterol metabolism | 20/1043 | 51/8465 | 9.73e-07 | 4.56e-05 | 3.67e-05 | 20 |
hsa0497911 | Liver | NAFLD | Cholesterol metabolism | 20/1043 | 51/8465 | 9.73e-07 | 4.56e-05 | 3.67e-05 | 20 |
hsa0501014 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa049792 | Liver | Cirrhotic | Cholesterol metabolism | 30/2530 | 51/8465 | 1.59e-05 | 1.39e-04 | 8.60e-05 | 30 |
hsa0501015 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa049793 | Liver | Cirrhotic | Cholesterol metabolism | 30/2530 | 51/8465 | 1.59e-05 | 1.39e-04 | 8.60e-05 | 30 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa049794 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
MDK | LRP1 | MDK_LRP1 | MK | Breast | DCIS |
MDK | LRP1 | MDK_LRP1 | MK | Breast | Healthy |
MDK | LRP1 | MDK_LRP1 | MK | Breast | IDC |
MDK | LRP1 | MDK_LRP1 | MK | Breast | Precancer |
MDK | LRP1 | MDK_LRP1 | MK | Cervix | ADJ |
MDK | LRP1 | MDK_LRP1 | MK | Cervix | CC |
MDK | LRP1 | MDK_LRP1 | MK | Cervix | Healthy |
MDK | LRP1 | MDK_LRP1 | MK | Cervix | Precancer |
MDK | LRP1 | MDK_LRP1 | MK | CRC | AD |
MDK | LRP1 | MDK_LRP1 | MK | CRC | ADJ |
MDK | LRP1 | MDK_LRP1 | MK | CRC | MSI-H |
MDK | LRP1 | MDK_LRP1 | MK | CRC | MSS |
MDK | LRP1 | MDK_LRP1 | MK | CRC | SER |
MDK | LRP1 | MDK_LRP1 | MK | Endometrium | ADJ |
MDK | LRP1 | MDK_LRP1 | MK | Endometrium | AEH |
MDK | LRP1 | MDK_LRP1 | MK | Endometrium | EEC |
MDK | LRP1 | MDK_LRP1 | MK | Endometrium | Healthy |
MDK | LRP1 | MDK_LRP1 | MK | Esophagus | ESCC |
MDK | LRP1 | MDK_LRP1 | MK | Esophagus | Healthy |
MDK | LRP1 | MDK_LRP1 | MK | GC | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRP1 | SNV | Missense_Mutation | novel | c.1064N>A | p.Gly355Glu | p.G355E | Q07954 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A1-A0SH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD |
LRP1 | SNV | Missense_Mutation | rs769600453 | c.11248N>T | p.Arg3750Trp | p.R3750W | Q07954 | protein_coding | deleterious(0.01) | possibly_damaging(0.545) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD |
LRP1 | SNV | Missense_Mutation | rs748577199 | c.2461N>C | p.Thr821Pro | p.T821P | Q07954 | protein_coding | tolerated(0.06) | benign(0.276) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
LRP1 | SNV | Missense_Mutation | c.8327C>T | p.Pro2776Leu | p.P2776L | Q07954 | protein_coding | tolerated(0.08) | benign(0.049) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD | |
LRP1 | SNV | Missense_Mutation | c.13037G>T | p.Arg4346Leu | p.R4346L | Q07954 | protein_coding | tolerated(0.14) | benign(0.069) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
LRP1 | SNV | Missense_Mutation | novel | c.2440N>C | p.Cys814Arg | p.C814R | Q07954 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
LRP1 | SNV | Missense_Mutation | novel | c.2441N>T | p.Cys814Phe | p.C814F | Q07954 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
LRP1 | SNV | Missense_Mutation | c.4843G>A | p.Asp1615Asn | p.D1615N | Q07954 | protein_coding | deleterious(0.03) | probably_damaging(0.985) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
LRP1 | SNV | Missense_Mutation | rs761146982 | c.5119N>G | p.Leu1707Val | p.L1707V | Q07954 | protein_coding | deleterious(0.05) | probably_damaging(0.967) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LRP1 | SNV | Missense_Mutation | c.13606N>A | p.Glu4536Lys | p.E4536K | Q07954 | protein_coding | deleterious(0.01) | benign(0.034) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4035 | LRP1 | KINASE, DRUGGABLE GENOME | ANTISENSE OLIGONUCLEOTIDES | 11095961 |
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