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Gene: DDX1 |
Gene summary for DDX1 |
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Gene information | Species | Human | Gene symbol | DDX1 | Gene ID | 1653 |
Gene name | DEAD-box helicase 1 | |
Gene Alias | DBP-RB | |
Cytomap | 2p24.3 | |
Gene Type | protein-coding | GO ID | GO:0000245 | UniProtAcc | A3RJH1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1653 | DDX1 | LZE2T | Human | Esophagus | ESCC | 1.99e-02 | 4.31e-01 | 0.082 |
1653 | DDX1 | LZE4T | Human | Esophagus | ESCC | 1.19e-10 | 4.16e-01 | 0.0811 |
1653 | DDX1 | LZE7T | Human | Esophagus | ESCC | 3.17e-05 | 3.15e-01 | 0.0667 |
1653 | DDX1 | LZE8T | Human | Esophagus | ESCC | 8.09e-03 | 7.79e-02 | 0.067 |
1653 | DDX1 | LZE20T | Human | Esophagus | ESCC | 1.02e-04 | 4.22e-02 | 0.0662 |
1653 | DDX1 | LZE22T | Human | Esophagus | ESCC | 7.06e-03 | 3.14e-01 | 0.068 |
1653 | DDX1 | LZE24T | Human | Esophagus | ESCC | 1.96e-08 | 2.56e-01 | 0.0596 |
1653 | DDX1 | P1T-E | Human | Esophagus | ESCC | 7.30e-06 | 3.18e-01 | 0.0875 |
1653 | DDX1 | P2T-E | Human | Esophagus | ESCC | 3.19e-30 | 6.22e-01 | 0.1177 |
1653 | DDX1 | P4T-E | Human | Esophagus | ESCC | 1.57e-22 | 6.00e-01 | 0.1323 |
1653 | DDX1 | P5T-E | Human | Esophagus | ESCC | 5.32e-13 | 2.61e-01 | 0.1327 |
1653 | DDX1 | P8T-E | Human | Esophagus | ESCC | 2.45e-21 | 3.62e-01 | 0.0889 |
1653 | DDX1 | P9T-E | Human | Esophagus | ESCC | 3.80e-15 | 3.76e-01 | 0.1131 |
1653 | DDX1 | P10T-E | Human | Esophagus | ESCC | 2.64e-36 | 5.99e-01 | 0.116 |
1653 | DDX1 | P11T-E | Human | Esophagus | ESCC | 1.50e-13 | 5.19e-01 | 0.1426 |
1653 | DDX1 | P12T-E | Human | Esophagus | ESCC | 1.70e-33 | 6.09e-01 | 0.1122 |
1653 | DDX1 | P15T-E | Human | Esophagus | ESCC | 1.73e-13 | 1.94e-01 | 0.1149 |
1653 | DDX1 | P16T-E | Human | Esophagus | ESCC | 1.53e-13 | 2.62e-01 | 0.1153 |
1653 | DDX1 | P17T-E | Human | Esophagus | ESCC | 3.51e-06 | 2.66e-01 | 0.1278 |
1653 | DDX1 | P19T-E | Human | Esophagus | ESCC | 7.37e-04 | 4.47e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315037 | Thyroid | PTC | protein-containing complex localization | 107/5968 | 220/18723 | 1.47e-07 | 2.82e-06 | 107 |
GO:00064058 | Thyroid | PTC | RNA export from nucleus | 50/5968 | 84/18723 | 1.59e-07 | 3.03e-06 | 50 |
GO:004312226 | Thyroid | PTC | regulation of I-kappaB kinase/NF-kappaB signaling | 118/5968 | 249/18723 | 2.04e-07 | 3.63e-06 | 118 |
GO:00714267 | Thyroid | PTC | ribonucleoprotein complex export from nucleus | 46/5968 | 76/18723 | 2.48e-07 | 4.32e-06 | 46 |
GO:000724926 | Thyroid | PTC | I-kappaB kinase/NF-kappaB signaling | 130/5968 | 281/18723 | 2.78e-07 | 4.80e-06 | 130 |
GO:000961520 | Thyroid | PTC | response to virus | 162/5968 | 367/18723 | 4.52e-07 | 7.41e-06 | 162 |
GO:0030518111 | Thyroid | PTC | intracellular steroid hormone receptor signaling pathway | 63/5968 | 116/18723 | 4.53e-07 | 7.41e-06 | 63 |
GO:004312320 | Thyroid | PTC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 91/5968 | 186/18723 | 8.76e-07 | 1.33e-05 | 91 |
GO:0071383112 | Thyroid | PTC | cellular response to steroid hormone stimulus | 98/5968 | 204/18723 | 9.83e-07 | 1.47e-05 | 98 |
GO:0000381111 | Thyroid | PTC | regulation of alternative mRNA splicing, via spliceosome | 37/5968 | 60/18723 | 1.93e-06 | 2.64e-05 | 37 |
GO:004340124 | Thyroid | PTC | steroid hormone mediated signaling pathway | 69/5968 | 136/18723 | 3.57e-06 | 4.58e-05 | 69 |
GO:000183715 | Thyroid | PTC | epithelial to mesenchymal transition | 76/5968 | 157/18723 | 1.10e-05 | 1.21e-04 | 76 |
GO:00064066 | Thyroid | PTC | mRNA export from nucleus | 34/5968 | 59/18723 | 3.88e-05 | 3.57e-04 | 34 |
GO:00714276 | Thyroid | PTC | mRNA-containing ribonucleoprotein complex export from nucleus | 34/5968 | 59/18723 | 3.88e-05 | 3.57e-04 | 34 |
GO:00105868 | Thyroid | PTC | miRNA metabolic process | 19/5968 | 27/18723 | 4.57e-05 | 4.11e-04 | 19 |
GO:00004636 | Thyroid | PTC | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 12/5968 | 15/18723 | 1.75e-04 | 1.33e-03 | 12 |
GO:0030521111 | Thyroid | PTC | androgen receptor signaling pathway | 25/5968 | 44/18723 | 5.43e-04 | 3.48e-03 | 25 |
GO:004876215 | Thyroid | PTC | mesenchymal cell differentiation | 99/5968 | 236/18723 | 6.72e-04 | 4.22e-03 | 99 |
GO:00002459 | Thyroid | PTC | spliceosomal complex assembly | 39/5968 | 79/18723 | 8.86e-04 | 5.40e-03 | 39 |
GO:00063026 | Thyroid | PTC | double-strand break repair | 103/5968 | 251/18723 | 1.30e-03 | 7.40e-03 | 103 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX1 | SNV | Missense_Mutation | c.2095N>A | p.Gly699Arg | p.G699R | Q92499 | protein_coding | tolerated(0.22) | benign(0.303) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
DDX1 | SNV | Missense_Mutation | novel | c.1433G>C | p.Gly478Ala | p.G478A | Q92499 | protein_coding | tolerated(0.09) | benign(0.255) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DDX1 | SNV | Missense_Mutation | novel | c.449C>T | p.Ser150Phe | p.S150F | Q92499 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-EW-A423-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
DDX1 | SNV | Missense_Mutation | novel | c.351G>T | p.Lys117Asn | p.K117N | Q92499 | protein_coding | tolerated(0.06) | possibly_damaging(0.787) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DDX1 | SNV | Missense_Mutation | c.1925N>A | p.Arg642Lys | p.R642K | Q92499 | protein_coding | tolerated(0.82) | benign(0.003) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
DDX1 | SNV | Missense_Mutation | c.238N>G | p.Thr80Ala | p.T80A | Q92499 | protein_coding | tolerated(0.59) | benign(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
DDX1 | SNV | Missense_Mutation | c.387G>A | p.Met129Ile | p.M129I | Q92499 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DDX1 | SNV | Missense_Mutation | c.1757N>G | p.Tyr586Cys | p.Y586C | Q92499 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
DDX1 | SNV | Missense_Mutation | novel | c.1274N>C | p.Phe425Ser | p.F425S | Q92499 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DDX1 | SNV | Missense_Mutation | c.1859N>T | p.Ala620Val | p.A620V | Q92499 | protein_coding | deleterious(0.01) | possibly_damaging(0.776) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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