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Gene: PDCD6 |
Gene summary for PDCD6 |
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Gene information | Species | Human | Gene symbol | PDCD6 | Gene ID | 10016 |
Gene name | programmed cell death 6 | |
Gene Alias | ALG-2 | |
Cytomap | 5p15.33 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | O75340 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10016 | PDCD6 | GSM4909281 | Human | Breast | IDC | 1.61e-02 | 2.51e-01 | 0.21 |
10016 | PDCD6 | GSM4909282 | Human | Breast | IDC | 1.04e-11 | 4.15e-01 | -0.0288 |
10016 | PDCD6 | GSM4909285 | Human | Breast | IDC | 2.91e-31 | 6.81e-01 | 0.21 |
10016 | PDCD6 | GSM4909288 | Human | Breast | IDC | 3.09e-02 | 8.18e-02 | 0.0988 |
10016 | PDCD6 | GSM4909290 | Human | Breast | IDC | 4.62e-03 | 2.82e-01 | 0.2096 |
10016 | PDCD6 | GSM4909291 | Human | Breast | IDC | 2.29e-05 | 3.55e-01 | 0.1753 |
10016 | PDCD6 | GSM4909293 | Human | Breast | IDC | 7.23e-123 | 1.22e+00 | 0.1581 |
10016 | PDCD6 | GSM4909294 | Human | Breast | IDC | 4.03e-10 | 3.25e-01 | 0.2022 |
10016 | PDCD6 | GSM4909296 | Human | Breast | IDC | 3.29e-11 | 1.60e-01 | 0.1524 |
10016 | PDCD6 | GSM4909297 | Human | Breast | IDC | 3.01e-07 | -3.60e-02 | 0.1517 |
10016 | PDCD6 | GSM4909298 | Human | Breast | IDC | 6.37e-07 | 2.93e-01 | 0.1551 |
10016 | PDCD6 | GSM4909304 | Human | Breast | IDC | 1.07e-06 | 2.28e-01 | 0.1636 |
10016 | PDCD6 | GSM4909308 | Human | Breast | IDC | 2.18e-02 | 2.21e-01 | 0.158 |
10016 | PDCD6 | GSM4909311 | Human | Breast | IDC | 1.24e-22 | -3.30e-01 | 0.1534 |
10016 | PDCD6 | GSM4909312 | Human | Breast | IDC | 1.80e-10 | -5.38e-02 | 0.1552 |
10016 | PDCD6 | GSM4909316 | Human | Breast | IDC | 1.55e-07 | 3.61e-01 | 0.21 |
10016 | PDCD6 | GSM4909317 | Human | Breast | IDC | 2.50e-20 | 5.49e-01 | 0.1355 |
10016 | PDCD6 | GSM4909318 | Human | Breast | IDC | 1.58e-08 | 5.55e-01 | 0.2031 |
10016 | PDCD6 | GSM4909319 | Human | Breast | IDC | 3.04e-31 | -1.81e-01 | 0.1563 |
10016 | PDCD6 | GSM4909320 | Human | Breast | IDC | 1.24e-05 | -2.12e-01 | 0.1575 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003086613 | Prostate | Tumor | cortical actin cytoskeleton organization | 15/3246 | 40/18723 | 1.91e-03 | 1.11e-02 | 15 |
GO:000690313 | Prostate | Tumor | vesicle targeting | 16/3246 | 45/18723 | 2.59e-03 | 1.43e-02 | 16 |
GO:00108241 | Prostate | Tumor | regulation of centrosome duplication | 16/3246 | 45/18723 | 2.59e-03 | 1.43e-02 | 16 |
GO:003508813 | Prostate | Tumor | establishment or maintenance of apical/basal cell polarity | 17/3246 | 49/18723 | 2.61e-03 | 1.43e-02 | 17 |
GO:006124513 | Prostate | Tumor | establishment or maintenance of bipolar cell polarity | 17/3246 | 49/18723 | 2.61e-03 | 1.43e-02 | 17 |
GO:012019215 | Prostate | Tumor | tight junction assembly | 23/3246 | 74/18723 | 2.69e-03 | 1.48e-02 | 23 |
GO:000704317 | Prostate | Tumor | cell-cell junction assembly | 39/3246 | 146/18723 | 2.93e-03 | 1.58e-02 | 39 |
GO:004820712 | Prostate | Tumor | vesicle targeting, rough ER to cis-Golgi | 7/3246 | 13/18723 | 3.02e-03 | 1.61e-02 | 7 |
GO:004820812 | Prostate | Tumor | COPII vesicle coating | 7/3246 | 13/18723 | 3.02e-03 | 1.61e-02 | 7 |
GO:190241012 | Prostate | Tumor | mitotic cytokinetic process | 10/3246 | 23/18723 | 3.08e-03 | 1.63e-02 | 10 |
GO:190353211 | Prostate | Tumor | positive regulation of secretion by cell | 67/3246 | 282/18723 | 3.53e-03 | 1.82e-02 | 67 |
GO:000651312 | Prostate | Tumor | protein monoubiquitination | 21/3246 | 67/18723 | 3.61e-03 | 1.86e-02 | 21 |
GO:012019315 | Prostate | Tumor | tight junction organization | 24/3246 | 80/18723 | 3.69e-03 | 1.89e-02 | 24 |
GO:003625712 | Prostate | Tumor | multivesicular body organization | 12/3246 | 31/18723 | 3.92e-03 | 1.99e-02 | 12 |
GO:006195212 | Prostate | Tumor | midbody abscission | 8/3246 | 17/18723 | 4.45e-03 | 2.20e-02 | 8 |
GO:004519713 | Prostate | Tumor | establishment or maintenance of epithelial cell apical/basal polarity | 15/3246 | 44/18723 | 5.49e-03 | 2.61e-02 | 15 |
GO:003970212 | Prostate | Tumor | viral budding via host ESCRT complex | 9/3246 | 21/18723 | 5.54e-03 | 2.61e-02 | 9 |
GO:004819912 | Prostate | Tumor | vesicle targeting, to, from or within Golgi | 9/3246 | 21/18723 | 5.54e-03 | 2.61e-02 | 9 |
GO:190134212 | Prostate | Tumor | regulation of vasculature development | 79/3246 | 348/18723 | 5.84e-03 | 2.71e-02 | 79 |
GO:004660511 | Prostate | Tumor | regulation of centrosome cycle | 16/3246 | 49/18723 | 6.74e-03 | 3.07e-02 | 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDCD6 | SNV | Missense_Mutation | novel | c.154N>G | p.Leu52Val | p.L52V | O75340 | protein_coding | deleterious(0) | possibly_damaging(0.544) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PDCD6 | deletion | Frame_Shift_Del | c.221delG | p.Arg74LeufsTer7 | p.R74Lfs*7 | O75340 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PDCD6 | SNV | Missense_Mutation | rs370878298 | c.541N>A | p.Glu181Lys | p.E181K | O75340 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-C5-A7XC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | rs545985005 | c.302C>T | p.Thr101Met | p.T101M | O75340 | protein_coding | tolerated(0.08) | benign(0.262) | TCGA-VS-A8QC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
PDCD6 | SNV | Missense_Mutation | rs139334790 | c.500N>A | p.Arg167His | p.R167H | O75340 | protein_coding | deleterious(0.05) | benign(0.017) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | c.235N>A | p.Gly79Ser | p.G79S | O75340 | protein_coding | tolerated(0.22) | benign(0.015) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PDCD6 | SNV | Missense_Mutation | rs767684079 | c.427C>T | p.Arg143Trp | p.R143W | O75340 | protein_coding | deleterious(0.03) | possibly_damaging(0.85) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | rs373052818 | c.367N>A | p.Gly123Ser | p.G123S | O75340 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | novel | c.448N>A | p.Asp150Asn | p.D150N | O75340 | protein_coding | tolerated(0.22) | possibly_damaging(0.852) | TCGA-AD-6548-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | rs139334790 | c.500N>A | p.Arg167His | p.R167H | O75340 | protein_coding | deleterious(0.05) | benign(0.017) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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