Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CHMP4B_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CHMP4B_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CHMP4B_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CHMP4B_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CHMP4B_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CHMP4B_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CHMP4B_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CHMP4B_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CHMP4B_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CHMP4B_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19024104 | Stomach | CAG | mitotic cytokinetic process | 4/552 | 23/18723 | 4.24e-03 | 3.82e-02 | 4 |
GO:00453241 | Stomach | CAG | late endosome to vacuole transport | 4/552 | 25/18723 | 5.78e-03 | 4.73e-02 | 4 |
GO:00901692 | Stomach | CAG | regulation of spindle assembly | 4/552 | 25/18723 | 5.78e-03 | 4.73e-02 | 4 |
GO:004440341 | Stomach | WIM | biological process involved in symbiotic interaction | 25/426 | 290/18723 | 1.33e-08 | 1.82e-06 | 25 |
GO:001603241 | Stomach | WIM | viral process | 30/426 | 415/18723 | 2.74e-08 | 3.20e-06 | 30 |
GO:001905841 | Stomach | WIM | viral life cycle | 25/426 | 317/18723 | 7.70e-08 | 7.63e-06 | 25 |
GO:007099741 | Stomach | WIM | neuron death | 24/426 | 361/18723 | 3.01e-06 | 1.78e-04 | 24 |
GO:006024941 | Stomach | WIM | anatomical structure homeostasis | 22/426 | 314/18723 | 3.36e-06 | 1.93e-04 | 22 |
GO:000189441 | Stomach | WIM | tissue homeostasis | 20/426 | 268/18723 | 3.64e-06 | 2.03e-04 | 20 |
GO:003133041 | Stomach | WIM | negative regulation of cellular catabolic process | 18/426 | 262/18723 | 3.38e-05 | 1.17e-03 | 18 |
GO:000660541 | Stomach | WIM | protein targeting | 20/426 | 314/18723 | 3.70e-05 | 1.24e-03 | 20 |
GO:005212641 | Stomach | WIM | movement in host environment | 14/426 | 175/18723 | 4.92e-05 | 1.51e-03 | 14 |
GO:005170141 | Stomach | WIM | biological process involved in interaction with host | 15/426 | 203/18723 | 6.66e-05 | 1.96e-03 | 15 |
GO:007259441 | Stomach | WIM | establishment of protein localization to organelle | 23/426 | 422/18723 | 1.10e-04 | 2.92e-03 | 23 |
GO:00066204 | Stomach | WIM | posttranslational protein targeting to endoplasmic reticulum membrane | 4/426 | 12/18723 | 1.13e-04 | 2.97e-03 | 4 |
GO:190121411 | Stomach | WIM | regulation of neuron death | 19/426 | 319/18723 | 1.40e-04 | 3.55e-03 | 19 |
GO:000989541 | Stomach | WIM | negative regulation of catabolic process | 18/426 | 320/18723 | 4.15e-04 | 7.87e-03 | 18 |
GO:000690011 | Stomach | WIM | vesicle budding from membrane | 7/426 | 61/18723 | 4.55e-04 | 8.34e-03 | 7 |
GO:007097211 | Stomach | WIM | protein localization to endoplasmic reticulum | 7/426 | 74/18723 | 1.46e-03 | 1.97e-02 | 7 |
GO:00450471 | Stomach | WIM | protein targeting to ER | 5/426 | 42/18723 | 2.53e-03 | 2.92e-02 | 5 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP4B | SNV | Missense_Mutation | | c.559G>A | p.Glu187Lys | p.E187K | Q9H444 | protein_coding | tolerated(0.36) | benign(0.025) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP4B | insertion | Frame_Shift_Ins | novel | c.471_472insTTTGTATGTAG | p.Glu158PhefsTer15 | p.E158Ffs*15 | Q9H444 | protein_coding | | | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CHMP4B | insertion | Frame_Shift_Ins | novel | c.473_474insCCTTGATAGTGCCACCTGTAGG | p.Glu158AspfsTer10 | p.E158Dfs*10 | Q9H444 | protein_coding | | | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CHMP4B | insertion | Frame_Shift_Ins | novel | c.364_365insT | p.Asn122IlefsTer6 | p.N122Ifs*6 | Q9H444 | protein_coding | | | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CHMP4B | deletion | Frame_Shift_Del | novel | c.367delN | p.Met123TrpfsTer9 | p.M123Wfs*9 | Q9H444 | protein_coding | | | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CHMP4B | SNV | Missense_Mutation | novel | c.202N>A | p.Ala68Thr | p.A68T | Q9H444 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CHMP4B | SNV | Missense_Mutation | novel | c.5C>T | p.Ser2Leu | p.S2L | Q9H444 | protein_coding | deleterious(0) | benign(0) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CHMP4B | SNV | Missense_Mutation | novel | c.122N>G | p.Glu41Gly | p.E41G | Q9H444 | protein_coding | deleterious(0) | possibly_damaging(0.833) | TCGA-A6-6652-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | cetuximab | SD |
CHMP4B | SNV | Missense_Mutation | rs746089715 | c.497N>T | p.Ala166Val | p.A166V | Q9H444 | protein_coding | tolerated(0.11) | probably_damaging(0.962) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CHMP4B | deletion | Frame_Shift_Del | | c.62delN | p.Gln23ArgfsTer14 | p.Q23Rfs*14 | Q9H444 | protein_coding | | | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |