Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/ARF1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ARF1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ARF1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ARF1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ARF1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ARF1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ARF1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ARF1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ARF1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ARF1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ARF1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004580716 | Prostate | Tumor | positive regulation of endocytosis | 33/3246 | 100/18723 | 1.04e-04 | 1.00e-03 | 33 |
GO:006164013 | Prostate | Tumor | cytoskeleton-dependent cytokinesis | 33/3246 | 100/18723 | 1.04e-04 | 1.00e-03 | 33 |
GO:009706112 | Prostate | Tumor | dendritic spine organization | 29/3246 | 84/18723 | 1.09e-04 | 1.04e-03 | 29 |
GO:000028113 | Prostate | Tumor | mitotic cytokinesis | 25/3246 | 71/18723 | 2.24e-04 | 1.91e-03 | 25 |
GO:009917312 | Prostate | Tumor | postsynapse organization | 47/3246 | 168/18723 | 3.94e-04 | 3.03e-03 | 47 |
GO:007169214 | Prostate | Tumor | protein localization to extracellular region | 89/3246 | 368/18723 | 4.80e-04 | 3.57e-03 | 89 |
GO:000930615 | Prostate | Tumor | protein secretion | 87/3246 | 359/18723 | 5.15e-04 | 3.78e-03 | 87 |
GO:003559215 | Prostate | Tumor | establishment of protein localization to extracellular region | 87/3246 | 360/18723 | 5.65e-04 | 4.10e-03 | 87 |
GO:000704113 | Prostate | Tumor | lysosomal transport | 34/3246 | 114/18723 | 7.00e-04 | 4.92e-03 | 34 |
GO:003431511 | Prostate | Tumor | regulation of Arp2/3 complex-mediated actin nucleation | 10/3246 | 21/18723 | 1.33e-03 | 8.31e-03 | 10 |
GO:003250612 | Prostate | Tumor | cytokinetic process | 15/3246 | 39/18723 | 1.42e-03 | 8.80e-03 | 15 |
GO:005070814 | Prostate | Tumor | regulation of protein secretion | 66/3246 | 268/18723 | 1.49e-03 | 9.19e-03 | 66 |
GO:005071413 | Prostate | Tumor | positive regulation of protein secretion | 38/3246 | 137/18723 | 1.60e-03 | 9.71e-03 | 38 |
GO:000703312 | Prostate | Tumor | vacuole organization | 47/3246 | 180/18723 | 1.95e-03 | 1.13e-02 | 47 |
GO:003162313 | Prostate | Tumor | receptor internalization | 32/3246 | 113/18723 | 2.51e-03 | 1.40e-02 | 32 |
GO:190241012 | Prostate | Tumor | mitotic cytokinetic process | 10/3246 | 23/18723 | 3.08e-03 | 1.63e-02 | 10 |
GO:004825914 | Prostate | Tumor | regulation of receptor-mediated endocytosis | 31/3246 | 110/18723 | 3.15e-03 | 1.65e-02 | 31 |
GO:00609991 | Prostate | Tumor | positive regulation of dendritic spine development | 15/3246 | 42/18723 | 3.32e-03 | 1.73e-02 | 15 |
GO:190353211 | Prostate | Tumor | positive regulation of secretion by cell | 67/3246 | 282/18723 | 3.53e-03 | 1.82e-02 | 67 |
GO:000202812 | Prostate | Tumor | regulation of sodium ion transport | 26/3246 | 90/18723 | 4.54e-03 | 2.24e-02 | 26 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARF1 | SNV | Missense_Mutation | | c.446N>A | p.Arg149His | p.R149H | P84077 | protein_coding | tolerated_low_confidence(0.16) | benign(0.013) | TCGA-AR-A1AL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | SD |
ARF1 | SNV | Missense_Mutation | novel | c.409N>A | p.Ala137Thr | p.A137T | P84077 | protein_coding | tolerated_low_confidence(0.14) | benign(0.003) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ARF1 | SNV | Missense_Mutation | | c.55C>T | p.Arg19Cys | p.R19C | P84077 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.591) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARF1 | SNV | Missense_Mutation | novel | c.452G>A | p.Arg151Lys | p.R151K | P84077 | protein_coding | deleterious_low_confidence(0.04) | benign(0.097) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARF1 | SNV | Missense_Mutation | novel | c.224N>A | p.Arg75Gln | p.R75Q | P84077 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.604) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARF1 | SNV | Missense_Mutation | | c.11T>G | p.Ile4Ser | p.I4S | P84077 | protein_coding | tolerated_low_confidence(0.59) | benign(0.003) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
ARF1 | SNV | Missense_Mutation | | c.377N>G | p.Asn126Ser | p.N126S | P84077 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.987) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARF1 | SNV | Missense_Mutation | novel | c.451A>G | p.Arg151Gly | p.R151G | P84077 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.873) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARF1 | insertion | Frame_Shift_Ins | novel | c.48dupA | p.Glu17ArgfsTer22 | p.E17Rfs*22 | P84077 | protein_coding | | | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
ARF1 | SNV | Missense_Mutation | novel | c.397N>A | p.Ala133Thr | p.A133T | P84077 | protein_coding | deleterious_low_confidence(0.02) | benign(0.158) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |