Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PPARA_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PPARA_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PPARA_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PPARA_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00511467 | Oral cavity | EOLP | striated muscle cell differentiation | 57/2218 | 283/18723 | 3.82e-05 | 5.25e-04 | 57 |
GO:00313482 | Oral cavity | EOLP | negative regulation of defense response | 53/2218 | 258/18723 | 4.05e-05 | 5.54e-04 | 53 |
GO:002240812 | Oral cavity | EOLP | negative regulation of cell-cell adhesion | 43/2218 | 196/18723 | 4.26e-05 | 5.79e-04 | 43 |
GO:003166823 | Oral cavity | EOLP | cellular response to extracellular stimulus | 51/2218 | 246/18723 | 4.36e-05 | 5.88e-04 | 51 |
GO:00486389 | Oral cavity | EOLP | regulation of developmental growth | 64/2218 | 330/18723 | 4.45e-05 | 5.96e-04 | 64 |
GO:004858815 | Oral cavity | EOLP | developmental cell growth | 49/2218 | 234/18723 | 4.67e-05 | 6.20e-04 | 49 |
GO:001470614 | Oral cavity | EOLP | striated muscle tissue development | 72/2218 | 384/18723 | 4.87e-05 | 6.43e-04 | 72 |
GO:000762317 | Oral cavity | EOLP | circadian rhythm | 45/2218 | 210/18723 | 5.24e-05 | 6.79e-04 | 45 |
GO:000717916 | Oral cavity | EOLP | transforming growth factor beta receptor signaling pathway | 43/2218 | 198/18723 | 5.48e-05 | 7.03e-04 | 43 |
GO:003292221 | Oral cavity | EOLP | circadian regulation of gene expression | 20/2218 | 68/18723 | 7.88e-05 | 9.51e-04 | 20 |
GO:19030382 | Oral cavity | EOLP | negative regulation of leukocyte cell-cell adhesion | 33/2218 | 141/18723 | 8.63e-05 | 1.02e-03 | 33 |
GO:004340123 | Oral cavity | EOLP | steroid hormone mediated signaling pathway | 32/2218 | 136/18723 | 9.85e-05 | 1.14e-03 | 32 |
GO:004506924 | Oral cavity | EOLP | regulation of viral genome replication | 23/2218 | 85/18723 | 9.95e-05 | 1.14e-03 | 23 |
GO:004259422 | Oral cavity | EOLP | response to starvation | 42/2218 | 197/18723 | 1.03e-04 | 1.17e-03 | 42 |
GO:190289324 | Oral cavity | EOLP | regulation of pri-miRNA transcription by RNA polymerase II | 17/2218 | 54/18723 | 1.05e-04 | 1.19e-03 | 17 |
GO:000609619 | Oral cavity | EOLP | glycolytic process | 22/2218 | 81/18723 | 1.32e-04 | 1.44e-03 | 22 |
GO:200037725 | Oral cavity | EOLP | regulation of reactive oxygen species metabolic process | 35/2218 | 157/18723 | 1.51e-04 | 1.62e-03 | 35 |
GO:000675719 | Oral cavity | EOLP | ATP generation from ADP | 22/2218 | 82/18723 | 1.60e-04 | 1.69e-03 | 22 |
GO:007259323 | Oral cavity | EOLP | reactive oxygen species metabolic process | 48/2218 | 239/18723 | 1.62e-04 | 1.70e-03 | 48 |
GO:00321023 | Oral cavity | EOLP | negative regulation of response to external stimulus | 75/2218 | 420/18723 | 1.74e-04 | 1.80e-03 | 75 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa049321 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa051601 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa049322 | Colorectum | SER | Non-alcoholic fatty liver disease | 75/1580 | 155/8465 | 2.16e-17 | 5.99e-16 | 4.35e-16 | 75 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa054153 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa049323 | Colorectum | SER | Non-alcoholic fatty liver disease | 75/1580 | 155/8465 | 2.16e-17 | 5.99e-16 | 4.35e-16 | 75 |
hsa049223 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa054158 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
hsa049328 | Colorectum | FAP | Non-alcoholic fatty liver disease | 54/1404 | 155/8465 | 1.98e-08 | 6.20e-07 | 3.77e-07 | 54 |
hsa049226 | Colorectum | FAP | Glucagon signaling pathway | 32/1404 | 107/8465 | 4.08e-04 | 3.10e-03 | 1.89e-03 | 32 |
hsa049312 | Colorectum | FAP | Insulin resistance | 32/1404 | 108/8465 | 4.90e-04 | 3.56e-03 | 2.16e-03 | 32 |
hsa04024 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa054159 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PPARA | MVA | Breast | Healthy | TNFRSF4,SH3TC1,SLFN11, etc. | 1.51e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
PPARA | MVA | Breast | Precancer | TNFRSF4,SH3TC1,SLFN11, etc. | 2.91e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
PPARA | PVA | Breast | Precancer | TNFRSF4,SH3TC1,SLFN11, etc. | 2.39e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
PPARA | cDC | Lung | IAC | CEP112,PIGL,AL683807.1, etc. | 1.94e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
PPARA | M1MAC | Prostate | Healthy | SLC18B1,PTPN9,TGFBR1, etc. | 1.52e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
PPARA | PTC | Thyroid | ADJ | CCDC69,SAA2,USP43, etc. | 2.14e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
PPARA | TFC | Thyroid | ATC | CCDC69,SAA2,USP43, etc. | 8.84e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ATC/regulons_activity_in_dotplot.png) |
PPARA | iATC | Thyroid | ATC | CCDC69,SAA2,USP43, etc. | 1.25e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ATC/regulons_activity_in_dotplot.png) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | T091317 | T091317 | 20350005 |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | simvastatin | SIMVASTATIN | 23930676,24598718,23252946 |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | BMS-687453 | CHEMBL1089501 | 20218621 |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | GTF505 | | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | ZYH-1 | | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | agonist | 135650110 | CLOFIBRATE | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | GFT14 | | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | agonist | 135650558 | LY-510929 | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | OLEIC ACID | OLEIC ACID | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | CIPROFIBRATE | CIPROFIBRATE | |