Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DNM2

Gene summary for DNM2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DNM2

Gene ID

1785

Gene namedynamin 2
Gene AliasCMT2M
Cytomap19p13.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

P50570


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1785DNM2HTA11_2487_2000001011HumanColorectumSER5.81e-066.22e-01-0.1808
1785DNM2HTA11_1938_2000001011HumanColorectumAD7.73e-034.93e-01-0.0811
1785DNM2HTA11_347_2000001011HumanColorectumAD1.01e-126.55e-01-0.1954
1785DNM2HTA11_411_2000001011HumanColorectumSER9.96e-111.32e+00-0.2602
1785DNM2HTA11_2112_2000001011HumanColorectumSER2.13e-078.58e-01-0.2196
1785DNM2HTA11_3361_2000001011HumanColorectumAD5.97e-086.46e-01-0.1207
1785DNM2HTA11_83_2000001011HumanColorectumSER8.68e-076.49e-01-0.1526
1785DNM2HTA11_696_2000001011HumanColorectumAD1.98e-229.09e-01-0.1464
1785DNM2HTA11_866_2000001011HumanColorectumAD9.16e-095.71e-01-0.1001
1785DNM2HTA11_1391_2000001011HumanColorectumAD3.56e-066.88e-01-0.059
1785DNM2HTA11_546_2000001011HumanColorectumAD4.16e-035.77e-01-0.0842
1785DNM2HTA11_99999970781_79442HumanColorectumMSS2.17e-21-6.53e-010.294
1785DNM2HTA11_99999971662_82457HumanColorectumMSS3.48e-02-2.35e-010.3859
1785DNM2HTA11_99999974143_84620HumanColorectumMSS6.66e-03-3.44e-010.3005
1785DNM2F007HumanColorectumFAP5.54e-04-2.86e-010.1176
1785DNM2A002-C-010HumanColorectumFAP1.59e-03-2.37e-010.242
1785DNM2A001-C-207HumanColorectumFAP5.01e-08-3.34e-010.1278
1785DNM2A015-C-203HumanColorectumFAP1.89e-36-3.39e-01-0.1294
1785DNM2A015-C-204HumanColorectumFAP5.78e-07-2.82e-01-0.0228
1785DNM2A014-C-040HumanColorectumFAP2.40e-09-4.97e-01-0.1184
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004800224Oral cavityEOLPantigen processing and presentation of peptide antigen24/221862/187235.49e-082.02e-0624
GO:000247824Oral cavityEOLPantigen processing and presentation of exogenous peptide antigen18/221838/187236.33e-082.30e-0618
GO:009758122Oral cavityEOLPlamellipodium organization30/221890/187236.89e-082.49e-0630
GO:000726522Oral cavityEOLPRas protein signal transduction74/2218337/187238.76e-083.09e-0674
GO:001604924Oral cavityEOLPcell growth97/2218482/187239.06e-083.15e-0697
GO:001988424Oral cavityEOLPantigen processing and presentation of exogenous antigen20/221847/187231.10e-073.71e-0620
GO:002260425Oral cavityEOLPregulation of cell morphogenesis69/2218309/187231.21e-074.01e-0669
GO:003003214Oral cavityEOLPlamellipodium assembly25/221872/187233.46e-071.01e-0525
GO:003010023Oral cavityEOLPregulation of endocytosis51/2218211/187234.24e-071.19e-0551
GO:007258321Oral cavityEOLPclathrin-dependent endocytosis19/221847/187236.00e-071.56e-0519
GO:003134621Oral cavityEOLPpositive regulation of cell projection organization74/2218353/187236.00e-071.56e-0574
GO:000689825Oral cavityEOLPreceptor-mediated endocytosis55/2218244/187231.64e-063.82e-0555
GO:007155916Oral cavityEOLPresponse to transforming growth factor beta56/2218256/187233.54e-067.58e-0556
GO:0010811110Oral cavityEOLPpositive regulation of cell-substrate adhesion33/2218123/187234.19e-068.76e-0533
GO:190274322Oral cavityEOLPregulation of lamellipodium organization19/221854/187236.95e-061.34e-0419
GO:007156016Oral cavityEOLPcellular response to transforming growth factor beta stimulus54/2218250/187237.76e-061.49e-0454
GO:004477222Oral cavityEOLPmitotic cell cycle phase transition81/2218424/187238.32e-061.59e-0481
GO:190274514Oral cavityEOLPpositive regulation of lamellipodium organization15/221837/187238.82e-061.65e-0415
GO:000689322Oral cavityEOLPGolgi to plasma membrane transport20/221860/187231.03e-051.84e-0420
GO:190211521Oral cavityEOLPregulation of organelle assembly43/2218186/187231.11e-051.94e-0443
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04144ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa05100ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa04666ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa04961ColorectumADEndocrine and other factor-regulated calcium reabsorption24/209253/84658.49e-045.93e-033.78e-0324
hsa041441ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa051001ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa051321ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa046661ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa049611ColorectumADEndocrine and other factor-regulated calcium reabsorption24/209253/84658.49e-045.93e-033.78e-0324
hsa051002ColorectumSERBacterial invasion of epithelial cells36/158077/84651.56e-083.45e-072.50e-0736
hsa041442ColorectumSEREndocytosis81/1580251/84651.14e-072.36e-061.71e-0681
hsa046662ColorectumSERFc gamma R-mediated phagocytosis39/158097/84655.84e-079.70e-067.04e-0639
hsa051322ColorectumSERSalmonella infection77/1580249/84651.56e-062.35e-051.71e-0577
hsa049612ColorectumSEREndocrine and other factor-regulated calcium reabsorption19/158053/84652.32e-031.75e-021.27e-0219
hsa051003ColorectumSERBacterial invasion of epithelial cells36/158077/84651.56e-083.45e-072.50e-0736
hsa041443ColorectumSEREndocytosis81/1580251/84651.14e-072.36e-061.71e-0681
hsa046663ColorectumSERFc gamma R-mediated phagocytosis39/158097/84655.84e-079.70e-067.04e-0639
hsa051323ColorectumSERSalmonella infection77/1580249/84651.56e-062.35e-051.71e-0577
hsa049613ColorectumSEREndocrine and other factor-regulated calcium reabsorption19/158053/84652.32e-031.75e-021.27e-0219
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DNM2SNVMissense_Mutationnovelc.1285N>Cp.Asp429Hisp.D429HP50570protein_codingdeleterious(0)probably_damaging(1)TCGA-AC-A2QI-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycytoxanCR
DNM2SNVMissense_Mutationnovelc.873N>Tp.Glu291Aspp.E291DP50570protein_codingtolerated(1)benign(0.007)TCGA-E9-A1RF-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapytamoxiphenSD
DNM2insertionFrame_Shift_Insnovelc.1822_1823insTGCCCAGCCAAAACTTTTTTTATAAAAAp.Asp608ValfsTer116p.D608Vfs*116P50570protein_codingTCGA-A2-A0CX-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
DNM2SNVMissense_Mutationnovelc.646N>Ap.Ala216Thrp.A216TP50570protein_codingdeleterious(0)probably_damaging(0.999)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DNM2SNVMissense_Mutationnovelc.2509N>Tp.Arg837Trpp.R837WP50570protein_codingdeleterious_low_confidence(0)possibly_damaging(0.639)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DNM2SNVMissense_Mutationc.1584N>Gp.Ile528Metp.I528MP50570protein_codingdeleterious(0.03)possibly_damaging(0.766)TCGA-C5-A1BQ-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinCR
DNM2SNVMissense_Mutationnovelc.766N>Gp.Arg256Glyp.R256GP50570protein_codingdeleterious(0.01)probably_damaging(0.997)TCGA-VS-A9UO-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DNM2SNVMissense_Mutationnovelc.767N>Cp.Arg256Thrp.R256TP50570protein_codingtolerated(0.06)probably_damaging(0.997)TCGA-VS-A9UO-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DNM2SNVMissense_Mutationc.886N>Ap.Leu296Ilep.L296IP50570protein_codingtolerated(0.2)possibly_damaging(0.823)TCGA-A6-5661-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
DNM2SNVMissense_Mutationrs749953105c.2170C>Tp.Arg724Cysp.R724CP50570protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AA-3864-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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