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Gene: ADM |
Gene summary for ADM |
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Gene information | Species | Human | Gene symbol | ADM | Gene ID | 133 |
Gene name | adrenomedullin | |
Gene Alias | AM | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P35318 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
133 | ADM | GSM4909282 | Human | Breast | IDC | 5.22e-03 | -2.85e-01 | -0.0288 |
133 | ADM | GSM4909285 | Human | Breast | IDC | 1.23e-09 | -3.62e-01 | 0.21 |
133 | ADM | GSM4909286 | Human | Breast | IDC | 4.79e-07 | -3.65e-01 | 0.1081 |
133 | ADM | GSM4909290 | Human | Breast | IDC | 1.20e-07 | -3.78e-01 | 0.2096 |
133 | ADM | GSM4909293 | Human | Breast | IDC | 1.09e-07 | -3.75e-01 | 0.1581 |
133 | ADM | GSM4909294 | Human | Breast | IDC | 7.44e-06 | -3.73e-01 | 0.2022 |
133 | ADM | GSM4909297 | Human | Breast | IDC | 5.62e-05 | -2.27e-01 | 0.1517 |
133 | ADM | GSM4909298 | Human | Breast | IDC | 3.90e-10 | -3.82e-01 | 0.1551 |
133 | ADM | GSM4909301 | Human | Breast | IDC | 1.30e-08 | -3.60e-01 | 0.1577 |
133 | ADM | GSM4909305 | Human | Breast | IDC | 6.31e-03 | -3.16e-01 | 0.0436 |
133 | ADM | GSM4909306 | Human | Breast | IDC | 1.86e-04 | -3.25e-01 | 0.1564 |
133 | ADM | GSM4909307 | Human | Breast | IDC | 1.51e-07 | -3.46e-01 | 0.1569 |
133 | ADM | GSM4909308 | Human | Breast | IDC | 2.69e-10 | -3.82e-01 | 0.158 |
133 | ADM | GSM4909311 | Human | Breast | IDC | 7.77e-09 | -3.51e-01 | 0.1534 |
133 | ADM | GSM4909312 | Human | Breast | IDC | 3.01e-07 | -3.36e-01 | 0.1552 |
133 | ADM | GSM4909313 | Human | Breast | IDC | 6.70e-03 | -2.86e-01 | 0.0391 |
133 | ADM | GSM4909319 | Human | Breast | IDC | 1.49e-12 | -3.90e-01 | 0.1563 |
133 | ADM | GSM4909320 | Human | Breast | IDC | 3.47e-02 | -3.63e-01 | 0.1575 |
133 | ADM | GSM4909321 | Human | Breast | IDC | 2.34e-05 | -3.11e-01 | 0.1559 |
133 | ADM | ctrl6 | Human | Breast | Precancer | 1.30e-23 | 1.15e+00 | -0.0061 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00192182 | Liver | HCC | regulation of steroid metabolic process | 55/7958 | 100/18723 | 7.79e-03 | 3.09e-02 | 55 |
GO:00075651 | Liver | HCC | female pregnancy | 99/7958 | 193/18723 | 8.24e-03 | 3.23e-02 | 99 |
GO:00315791 | Liver | HCC | membrane raft organization | 17/7958 | 25/18723 | 8.94e-03 | 3.45e-02 | 17 |
GO:00607114 | Liver | HCC | labyrinthine layer development | 27/7958 | 44/18723 | 8.98e-03 | 3.46e-02 | 27 |
GO:00346371 | Liver | HCC | cellular carbohydrate biosynthetic process | 44/7958 | 78/18723 | 9.13e-03 | 3.51e-02 | 44 |
GO:006102822 | Liver | HCC | establishment of endothelial barrier | 28/7958 | 46/18723 | 9.16e-03 | 3.52e-02 | 28 |
GO:00721754 | Liver | HCC | epithelial tube formation | 70/7958 | 132/18723 | 9.29e-03 | 3.57e-02 | 70 |
GO:000188512 | Liver | HCC | endothelial cell development | 37/7958 | 64/18723 | 9.63e-03 | 3.63e-02 | 37 |
GO:006145811 | Liver | HCC | reproductive system development | 205/7958 | 427/18723 | 1.16e-02 | 4.27e-02 | 205 |
GO:00351484 | Liver | HCC | tube formation | 77/7958 | 148/18723 | 1.20e-02 | 4.39e-02 | 77 |
GO:00514946 | Liver | HCC | negative regulation of cytoskeleton organization | 84/7958 | 163/18723 | 1.22e-02 | 4.43e-02 | 84 |
GO:003083712 | Liver | HCC | negative regulation of actin filament polymerization | 37/7958 | 65/18723 | 1.33e-02 | 4.77e-02 | 37 |
GO:00607134 | Liver | HCC | labyrinthine layer morphogenesis | 15/7958 | 22/18723 | 1.35e-02 | 4.80e-02 | 15 |
GO:00442641 | Liver | HCC | cellular polysaccharide metabolic process | 52/7958 | 96/18723 | 1.38e-02 | 4.91e-02 | 52 |
GO:190002632 | Liver | Cyst | positive regulation of substrate adhesion-dependent cell spreading | 7/496 | 41/18723 | 9.04e-05 | 4.22e-03 | 7 |
GO:190002432 | Liver | Cyst | regulation of substrate adhesion-dependent cell spreading | 8/496 | 57/18723 | 1.21e-04 | 5.28e-03 | 8 |
GO:004578522 | Liver | Cyst | positive regulation of cell adhesion | 25/496 | 437/18723 | 2.79e-04 | 9.40e-03 | 25 |
GO:190290332 | Liver | Cyst | regulation of supramolecular fiber organization | 22/496 | 383/18723 | 6.04e-04 | 1.73e-02 | 22 |
GO:000701532 | Liver | Cyst | actin filament organization | 24/496 | 442/18723 | 7.70e-04 | 2.07e-02 | 24 |
GO:000188522 | Liver | Cyst | endothelial cell development | 7/496 | 64/18723 | 1.48e-03 | 3.49e-02 | 7 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | ADJ |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | DCIS |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Breast | DCIS |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | Healthy |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | IDC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Breast | IDC |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | Precancer |
ADM | CALCRL | ADM_CALCRL | CALCR | Cervix | ADJ |
ADM | CALCRL | ADM_CALCRL | CALCR | Cervix | CC |
ADM | CALCRL | ADM_CALCRL | CALCR | Cervix | Precancer |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Cervix | Precancer |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | ADJ |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | CRC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | FAP |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | ADJ |
ADM | CALCRL | ADM_CALCRL | CALCR | Endometrium | AEH |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | AEH |
ADM | CALCRL | ADM_CALCRL | CALCR | Endometrium | EEC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | EEC |
ADM | CALCRL | ADM_CALCRL | CALCR | Endometrium | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADM | SNV | Missense_Mutation | rs770053274 | c.224N>A | p.Gly75Asp | p.G75D | P35318 | protein_coding | tolerated(0.97) | benign(0.012) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ADM | SNV | Missense_Mutation | novel | c.215N>G | p.Asp72Gly | p.D72G | P35318 | protein_coding | deleterious(0.04) | possibly_damaging(0.478) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ADM | SNV | Missense_Mutation | c.448C>T | p.Arg150Cys | p.R150C | P35318 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADM | SNV | Missense_Mutation | c.20N>T | p.Ala7Val | p.A7V | P35318 | protein_coding | deleterious(0.02) | benign(0.078) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ADM | insertion | Frame_Shift_Ins | rs773405081 | c.523_524insC | p.Ser178GlufsTer19 | p.S178Efs*19 | P35318 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADM | insertion | Frame_Shift_Ins | rs773405081 | c.523_524insC | p.Ser178GlufsTer19 | p.S178Efs*19 | P35318 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADM | SNV | Missense_Mutation | c.155N>G | p.Tyr52Cys | p.Y52C | P35318 | protein_coding | tolerated(0.16) | possibly_damaging(0.819) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADM | SNV | Missense_Mutation | novel | c.553N>A | p.Leu185Ile | p.L185I | P35318 | protein_coding | deleterious_low_confidence(0) | benign(0.011) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADM | insertion | Frame_Shift_Ins | rs773405081 | c.523_524insC | p.Ser178GlufsTer19 | p.S178Efs*19 | P35318 | protein_coding | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADM | insertion | Frame_Shift_Ins | rs773405081 | c.530dupC | p.Ser178GlufsTer19 | p.S178Efs*19 | P35318 | protein_coding | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | PD-98059 | CHEMBL35482 | 10830296 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | NSC-87877 | CHEMBL472004 | 22884224 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | INDOMETHACIN | INDOMETHACIN | 10830296 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | NSC-106221 | CHEMBL2063510 | 22884224 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | paroxetine | PAROXETINE | 19636336 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | INSULIN | INSULIN | 12668590 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | TPA | ALTEPLASE | 10848972 |
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