![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CA1 |
Gene summary for CA1 |
![]() |
Gene information | Species | Human | Gene symbol | CA1 | Gene ID | 759 |
Gene name | carbonic anhydrase 1 | |
Gene Alias | CA-I | |
Cytomap | 8q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006730 | UniProtAcc | P00915 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
759 | CA1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.47e-04 | -2.33e-01 | 0.0155 |
759 | CA1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.04e-27 | 2.26e+00 | -0.1954 |
759 | CA1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.31e-02 | 2.07e+00 | -0.2602 |
759 | CA1 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.28e-14 | 1.10e+00 | -0.1464 |
759 | CA1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.61e-02 | 6.63e-01 | -0.1001 |
759 | CA1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.28e-09 | 3.25e+00 | -0.1706 |
759 | CA1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.56e-25 | 3.91e+00 | -0.2061 |
759 | CA1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.01e-06 | 2.38e+00 | -0.1462 |
759 | CA1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.76e-04 | -2.43e-01 | 0.096 |
759 | CA1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.06e-05 | -2.30e-01 | 0.0674 |
759 | CA1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.27e-03 | -2.40e-01 | 0.294 |
759 | CA1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.49e-05 | -2.46e-01 | 0.3859 |
759 | CA1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.76e-05 | -2.45e-01 | 0.3005 |
759 | CA1 | A001-C-207 | Human | Colorectum | FAP | 6.53e-06 | -2.50e-01 | 0.1278 |
759 | CA1 | A002-C-201 | Human | Colorectum | FAP | 4.40e-09 | -2.50e-01 | 0.0324 |
759 | CA1 | A002-C-203 | Human | Colorectum | FAP | 9.63e-08 | -2.47e-01 | 0.2786 |
759 | CA1 | A001-C-119 | Human | Colorectum | FAP | 1.41e-04 | -2.50e-01 | -0.1557 |
759 | CA1 | A001-C-108 | Human | Colorectum | FAP | 2.16e-03 | -2.07e-01 | -0.0272 |
759 | CA1 | A002-C-205 | Human | Colorectum | FAP | 1.28e-05 | -2.21e-01 | -0.1236 |
759 | CA1 | A014-C-108 | Human | Colorectum | FAP | 2.37e-02 | -2.31e-01 | -0.124 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062828 | Thyroid | PTC | regulation of DNA repair | 65/5968 | 130/18723 | 1.25e-05 | 1.36e-04 | 65 |
GO:004657817 | Thyroid | PTC | regulation of Ras protein signal transduction | 88/5968 | 189/18723 | 1.62e-05 | 1.70e-04 | 88 |
GO:2001237113 | Thyroid | PTC | negative regulation of extrinsic apoptotic signaling pathway | 51/5968 | 97/18723 | 1.83e-05 | 1.88e-04 | 51 |
GO:004277010 | Thyroid | PTC | signal transduction in response to DNA damage | 81/5968 | 172/18723 | 2.07e-05 | 2.08e-04 | 81 |
GO:00459307 | Thyroid | PTC | negative regulation of mitotic cell cycle | 105/5968 | 235/18723 | 2.41e-05 | 2.39e-04 | 105 |
GO:20007566 | Thyroid | PTC | regulation of peptidyl-lysine acetylation | 36/5968 | 63/18723 | 2.98e-05 | 2.86e-04 | 36 |
GO:00070595 | Thyroid | PTC | chromosome segregation | 146/5968 | 346/18723 | 2.99e-05 | 2.87e-04 | 146 |
GO:00310626 | Thyroid | PTC | positive regulation of histone methylation | 26/5968 | 41/18723 | 3.23e-05 | 3.07e-04 | 26 |
GO:19019917 | Thyroid | PTC | negative regulation of mitotic cell cycle phase transition | 83/5968 | 179/18723 | 3.34e-05 | 3.17e-04 | 83 |
GO:00518659 | Thyroid | PTC | protein autoubiquitination | 40/5968 | 73/18723 | 4.17e-05 | 3.80e-04 | 40 |
GO:20010229 | Thyroid | PTC | positive regulation of response to DNA damage stimulus | 53/5968 | 105/18723 | 5.51e-05 | 4.89e-04 | 53 |
GO:00328866 | Thyroid | PTC | regulation of microtubule-based process | 105/5968 | 240/18723 | 6.91e-05 | 6.03e-04 | 105 |
GO:001657110 | Thyroid | PTC | histone methylation | 67/5968 | 141/18723 | 7.31e-05 | 6.31e-04 | 67 |
GO:190204120 | Thyroid | PTC | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 29/5968 | 49/18723 | 7.32e-05 | 6.31e-04 | 29 |
GO:00439663 | Thyroid | PTC | histone H3 acetylation | 34/5968 | 61/18723 | 9.78e-05 | 8.05e-04 | 34 |
GO:000647910 | Thyroid | PTC | protein methylation | 82/5968 | 181/18723 | 1.01e-04 | 8.21e-04 | 82 |
GO:000821310 | Thyroid | PTC | protein alkylation | 82/5968 | 181/18723 | 1.01e-04 | 8.21e-04 | 82 |
GO:0034612111 | Thyroid | PTC | response to tumor necrosis factor | 109/5968 | 253/18723 | 1.08e-04 | 8.69e-04 | 109 |
GO:00310606 | Thyroid | PTC | regulation of histone methylation | 37/5968 | 69/18723 | 1.46e-04 | 1.13e-03 | 37 |
GO:00350655 | Thyroid | PTC | regulation of histone acetylation | 30/5968 | 54/18723 | 2.68e-04 | 1.91e-03 | 30 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CA1 | SNV | Missense_Mutation | c.539T>G | p.Phe180Cys | p.F180C | P00915 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1FJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CA1 | SNV | Missense_Mutation | novel | c.83N>G | p.Asn28Ser | p.N28S | P00915 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CA1 | SNV | Missense_Mutation | novel | c.13G>A | p.Asp5Asn | p.D5N | P00915 | protein_coding | tolerated(0.97) | benign(0) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CA1 | SNV | Missense_Mutation | rs141945543 | c.715G>A | p.Ala239Thr | p.A239T | P00915 | protein_coding | tolerated(0.3) | benign(0.333) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
CA1 | SNV | Missense_Mutation | c.208N>C | p.Asn70His | p.N70H | P00915 | protein_coding | deleterious(0.02) | possibly_damaging(0.733) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CA1 | insertion | Frame_Shift_Ins | novel | c.192_193insG | p.His65AlafsTer8 | p.H65Afs*8 | P00915 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
CA1 | SNV | Missense_Mutation | c.40C>A | p.Pro14Thr | p.P14T | P00915 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CA1 | SNV | Missense_Mutation | c.358N>A | p.His120Asn | p.H120N | P00915 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
CA1 | SNV | Missense_Mutation | rs121909578 | c.740N>A | p.Arg247His | p.R247H | P00915 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CA1 | SNV | Missense_Mutation | novel | c.344N>G | p.Tyr115Cys | p.Y115C | P00915 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
759 | CA1 | DRUGGABLE GENOME, ENZYME | DICHLORPHENAMIDE | DICHLORPHENAMIDE | ||
759 | CA1 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1200814 | ACETAZOLAMIDE SODIUM | |
759 | CA1 | DRUGGABLE GENOME, ENZYME | ZONISAMIDE | ZONISAMIDE | ||
759 | CA1 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL166863 | POLMACOXIB | |
759 | CA1 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103435 | METHOCARBAMOL | |
759 | CA1 | DRUGGABLE GENOME, ENZYME | inhibitor | 178102191 | ||
759 | CA1 | DRUGGABLE GENOME, ENZYME | inhibitor | 381118859 | ||
759 | CA1 | DRUGGABLE GENOME, ENZYME | Ethoxzolamide | ETHOXZOLAMIDE | ||
759 | CA1 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103398 | ACETAZOLAMIDE | |
759 | CA1 | DRUGGABLE GENOME, ENZYME | activator | 178100344 | HISTIDINE |
Page: 1 2 3 4 5 6 |