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Gene: AIP |
Gene summary for AIP |
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Gene information | Species | Human | Gene symbol | AIP | Gene ID | 9049 |
Gene name | aryl hydrocarbon receptor interacting protein | |
Gene Alias | ARA9 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | O00170 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9049 | AIP | LZE2T | Human | Esophagus | ESCC | 7.16e-03 | 3.44e-01 | 0.082 |
9049 | AIP | LZE4T | Human | Esophagus | ESCC | 5.21e-13 | 4.56e-01 | 0.0811 |
9049 | AIP | LZE7T | Human | Esophagus | ESCC | 3.52e-12 | 6.40e-01 | 0.0667 |
9049 | AIP | LZE8T | Human | Esophagus | ESCC | 1.44e-09 | 3.03e-01 | 0.067 |
9049 | AIP | LZE20T | Human | Esophagus | ESCC | 8.87e-12 | 5.75e-01 | 0.0662 |
9049 | AIP | LZE22D1 | Human | Esophagus | HGIN | 5.76e-05 | 1.16e-01 | 0.0595 |
9049 | AIP | LZE22T | Human | Esophagus | ESCC | 1.07e-02 | 6.36e-01 | 0.068 |
9049 | AIP | LZE24T | Human | Esophagus | ESCC | 9.48e-25 | 7.38e-01 | 0.0596 |
9049 | AIP | LZE21T | Human | Esophagus | ESCC | 2.31e-02 | 2.23e-01 | 0.0655 |
9049 | AIP | LZE6T | Human | Esophagus | ESCC | 3.11e-11 | 5.41e-01 | 0.0845 |
9049 | AIP | P1T-E | Human | Esophagus | ESCC | 2.44e-08 | 6.42e-01 | 0.0875 |
9049 | AIP | P2T-E | Human | Esophagus | ESCC | 3.84e-34 | 5.80e-01 | 0.1177 |
9049 | AIP | P4T-E | Human | Esophagus | ESCC | 1.14e-51 | 1.28e+00 | 0.1323 |
9049 | AIP | P5T-E | Human | Esophagus | ESCC | 2.70e-52 | 1.01e+00 | 0.1327 |
9049 | AIP | P8T-E | Human | Esophagus | ESCC | 4.31e-69 | 1.17e+00 | 0.0889 |
9049 | AIP | P9T-E | Human | Esophagus | ESCC | 1.19e-29 | 6.04e-01 | 0.1131 |
9049 | AIP | P10T-E | Human | Esophagus | ESCC | 2.84e-30 | 5.74e-01 | 0.116 |
9049 | AIP | P11T-E | Human | Esophagus | ESCC | 2.80e-20 | 9.70e-01 | 0.1426 |
9049 | AIP | P12T-E | Human | Esophagus | ESCC | 1.62e-44 | 7.04e-01 | 0.1122 |
9049 | AIP | P15T-E | Human | Esophagus | ESCC | 4.79e-40 | 1.19e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004348811 | Liver | Cirrhotic | regulation of mRNA stability | 69/4634 | 158/18723 | 1.44e-07 | 3.87e-06 | 69 |
GO:004348711 | Liver | Cirrhotic | regulation of RNA stability | 73/4634 | 170/18723 | 1.44e-07 | 3.87e-06 | 73 |
GO:00072494 | Liver | Cirrhotic | I-kappaB kinase/NF-kappaB signaling | 108/4634 | 281/18723 | 2.21e-07 | 5.64e-06 | 108 |
GO:004873212 | Liver | Cirrhotic | gland development | 154/4634 | 436/18723 | 4.03e-07 | 9.42e-06 | 154 |
GO:003133012 | Liver | Cirrhotic | negative regulation of cellular catabolic process | 101/4634 | 262/18723 | 4.57e-07 | 1.05e-05 | 101 |
GO:006101311 | Liver | Cirrhotic | regulation of mRNA catabolic process | 70/4634 | 166/18723 | 5.91e-07 | 1.30e-05 | 70 |
GO:004593612 | Liver | Cirrhotic | negative regulation of phosphate metabolic process | 154/4634 | 441/18723 | 8.78e-07 | 1.83e-05 | 154 |
GO:001056312 | Liver | Cirrhotic | negative regulation of phosphorus metabolic process | 154/4634 | 442/18723 | 1.02e-06 | 2.11e-05 | 154 |
GO:00703012 | Liver | Cirrhotic | cellular response to hydrogen peroxide | 46/4634 | 98/18723 | 1.49e-06 | 2.93e-05 | 46 |
GO:00070292 | Liver | Cirrhotic | endoplasmic reticulum organization | 42/4634 | 87/18723 | 1.67e-06 | 3.22e-05 | 42 |
GO:00431225 | Liver | Cirrhotic | regulation of I-kappaB kinase/NF-kappaB signaling | 95/4634 | 249/18723 | 1.68e-06 | 3.22e-05 | 95 |
GO:006104112 | Liver | Cirrhotic | regulation of wound healing | 58/4634 | 134/18723 | 1.95e-06 | 3.65e-05 | 58 |
GO:004232612 | Liver | Cirrhotic | negative regulation of phosphorylation | 135/4634 | 385/18723 | 3.17e-06 | 5.58e-05 | 135 |
GO:00106397 | Liver | Cirrhotic | negative regulation of organelle organization | 124/4634 | 348/18723 | 3.20e-06 | 5.60e-05 | 124 |
GO:000020911 | Liver | Cirrhotic | protein polyubiquitination | 89/4634 | 236/18723 | 6.09e-06 | 9.80e-05 | 89 |
GO:00086256 | Liver | Cirrhotic | extrinsic apoptotic signaling pathway via death domain receptors | 39/4634 | 82/18723 | 6.14e-06 | 9.82e-05 | 39 |
GO:003424911 | Liver | Cirrhotic | negative regulation of cellular amide metabolic process | 100/4634 | 273/18723 | 7.34e-06 | 1.13e-04 | 100 |
GO:20012377 | Liver | Cirrhotic | negative regulation of extrinsic apoptotic signaling pathway | 44/4634 | 97/18723 | 7.61e-06 | 1.15e-04 | 44 |
GO:190303412 | Liver | Cirrhotic | regulation of response to wounding | 67/4634 | 167/18723 | 7.99e-06 | 1.21e-04 | 67 |
GO:00073463 | Liver | Cirrhotic | regulation of mitotic cell cycle | 154/4634 | 457/18723 | 8.73e-06 | 1.29e-04 | 154 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AIP | SNV | Missense_Mutation | rs574205552 | c.133G>A | p.Asp45Asn | p.D45N | O00170 | protein_coding | tolerated(0.47) | benign(0) | TCGA-C8-A12O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AIP | SNV | Missense_Mutation | c.52N>C | p.Ile18Leu | p.I18L | O00170 | protein_coding | tolerated(1) | benign(0.001) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AIP | SNV | Missense_Mutation | rs4930199 | c.920G>A | p.Arg307Gln | p.R307Q | O00170 | protein_coding | tolerated(0.22) | benign(0.022) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AIP | SNV | Missense_Mutation | novel | c.190N>G | p.Ile64Val | p.I64V | O00170 | protein_coding | tolerated(0.57) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
AIP | SNV | Missense_Mutation | c.504N>T | p.Trp168Cys | p.W168C | O00170 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AIP | SNV | Missense_Mutation | rs752553438 | c.160N>T | p.Arg54Trp | p.R54W | O00170 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AIP | SNV | Missense_Mutation | novel | c.138N>T | p.Glu46Asp | p.E46D | O00170 | protein_coding | tolerated(0.15) | benign(0.011) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
AIP | SNV | Missense_Mutation | novel | c.336N>T | p.Lys112Asn | p.K112N | O00170 | protein_coding | deleterious(0) | benign(0.107) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
AIP | SNV | Missense_Mutation | novel | c.505G>A | p.Ala169Thr | p.A169T | O00170 | protein_coding | tolerated(0.32) | probably_damaging(0.947) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AIP | SNV | Missense_Mutation | novel | c.474G>C | p.Glu158Asp | p.E158D | O00170 | protein_coding | tolerated(0.17) | benign(0.249) | TCGA-CN-4730-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9049 | AIP | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | TCDD | 10986286 |
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