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Gene: BMP7 |
Gene summary for BMP7 |
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Gene information | Species | Human | Gene symbol | BMP7 | Gene ID | 655 |
Gene name | bone morphogenetic protein 7 | |
Gene Alias | OP-1 | |
Cytomap | 20q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K571 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
655 | BMP7 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 1.99e-01 | 0.0528 |
655 | BMP7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.40e-09 | 1.80e-01 | 0.294 |
655 | BMP7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.02e-55 | 1.15e+00 | 0.3859 |
655 | BMP7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.69e-51 | 7.99e-01 | 0.3005 |
655 | BMP7 | A001-C-119 | Human | Colorectum | FAP | 4.39e-03 | 2.33e-01 | -0.1557 |
655 | BMP7 | A015-C-005 | Human | Colorectum | FAP | 5.50e-03 | 1.91e-01 | -0.0336 |
655 | BMP7 | CRC-1-8810 | Human | Colorectum | CRC | 5.87e-11 | 4.35e-01 | 0.6257 |
655 | BMP7 | CRC-3-11773 | Human | Colorectum | CRC | 5.54e-31 | 7.56e-01 | 0.2564 |
655 | BMP7 | LZE4T | Human | Esophagus | ESCC | 4.78e-06 | 1.59e-01 | 0.0811 |
655 | BMP7 | LZE7T | Human | Esophagus | ESCC | 1.80e-04 | 4.93e-01 | 0.0667 |
655 | BMP7 | LZE8T | Human | Esophagus | ESCC | 4.93e-02 | 4.86e-03 | 0.067 |
655 | BMP7 | LZE22D1 | Human | Esophagus | HGIN | 4.82e-03 | 1.34e-01 | 0.0595 |
655 | BMP7 | LZE22T | Human | Esophagus | ESCC | 7.19e-03 | 2.23e-01 | 0.068 |
655 | BMP7 | LZE24T | Human | Esophagus | ESCC | 7.78e-05 | 3.05e-01 | 0.0596 |
655 | BMP7 | LZE21T | Human | Esophagus | ESCC | 1.29e-06 | 2.89e-01 | 0.0655 |
655 | BMP7 | P2T-E | Human | Esophagus | ESCC | 4.50e-38 | 9.78e-01 | 0.1177 |
655 | BMP7 | P4T-E | Human | Esophagus | ESCC | 8.17e-30 | 9.66e-01 | 0.1323 |
655 | BMP7 | P5T-E | Human | Esophagus | ESCC | 8.35e-12 | 3.30e-01 | 0.1327 |
655 | BMP7 | P8T-E | Human | Esophagus | ESCC | 1.34e-11 | 6.83e-03 | 0.0889 |
655 | BMP7 | P9T-E | Human | Esophagus | ESCC | 2.35e-15 | 2.90e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487545 | Thyroid | ATC | branching morphogenesis of an epithelial tube | 71/6293 | 151/18723 | 4.18e-04 | 2.50e-03 | 71 |
GO:000721915 | Thyroid | ATC | Notch signaling pathway | 79/6293 | 172/18723 | 5.08e-04 | 2.96e-03 | 79 |
GO:00609933 | Thyroid | ATC | kidney morphogenesis | 47/6293 | 93/18723 | 5.40e-04 | 3.13e-03 | 47 |
GO:004340926 | Thyroid | ATC | negative regulation of MAPK cascade | 82/6293 | 180/18723 | 5.51e-04 | 3.19e-03 | 82 |
GO:0001892111 | Thyroid | ATC | embryonic placenta development | 42/6293 | 82/18723 | 7.34e-04 | 4.11e-03 | 42 |
GO:004873811 | Thyroid | ATC | cardiac muscle tissue development | 103/6293 | 236/18723 | 7.93e-04 | 4.37e-03 | 103 |
GO:000758418 | Thyroid | ATC | response to nutrient | 78/6293 | 174/18723 | 1.31e-03 | 6.85e-03 | 78 |
GO:000320612 | Thyroid | ATC | cardiac chamber morphogenesis | 57/6293 | 121/18723 | 1.39e-03 | 7.20e-03 | 57 |
GO:006041111 | Thyroid | ATC | cardiac septum morphogenesis | 35/6293 | 68/18723 | 1.76e-03 | 8.71e-03 | 35 |
GO:0003197 | Thyroid | ATC | endocardial cushion development | 25/6293 | 45/18723 | 2.00e-03 | 9.59e-03 | 25 |
GO:0003203 | Thyroid | ATC | endocardial cushion morphogenesis | 21/6293 | 36/18723 | 2.01e-03 | 9.59e-03 | 21 |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
GO:00351074 | Thyroid | ATC | appendage morphogenesis | 63/6293 | 138/18723 | 2.13e-03 | 1.00e-02 | 63 |
GO:00351084 | Thyroid | ATC | limb morphogenesis | 63/6293 | 138/18723 | 2.13e-03 | 1.00e-02 | 63 |
GO:003505111 | Thyroid | ATC | cardiocyte differentiation | 70/6293 | 156/18723 | 2.18e-03 | 1.02e-02 | 70 |
GO:0009755110 | Thyroid | ATC | hormone-mediated signaling pathway | 83/6293 | 190/18723 | 2.34e-03 | 1.09e-02 | 83 |
GO:00487368 | Thyroid | ATC | appendage development | 76/6293 | 172/18723 | 2.41e-03 | 1.12e-02 | 76 |
GO:00601738 | Thyroid | ATC | limb development | 76/6293 | 172/18723 | 2.41e-03 | 1.12e-02 | 76 |
GO:003806122 | Thyroid | ATC | NIK/NF-kappaB signaling | 64/6293 | 143/18723 | 3.53e-03 | 1.57e-02 | 64 |
GO:00074113 | Thyroid | ATC | axon guidance | 96/6293 | 227/18723 | 3.74e-03 | 1.63e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043604 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043605 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043606 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa043904 | Colorectum | CRC | Hippo signaling pathway | 32/1091 | 157/8465 | 5.17e-03 | 2.72e-02 | 1.84e-02 | 32 |
hsa043607 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa043905 | Colorectum | CRC | Hippo signaling pathway | 32/1091 | 157/8465 | 5.17e-03 | 2.72e-02 | 1.84e-02 | 32 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
BMP7 | ACVR1_ACVR2A | BMP7_ACVR1_ACVR2A | BMP | Cervix | CC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Cervix | CC |
BMP7 | BMPR1A_ACVR2A | BMP7_BMPR1A_ACVR2A | BMP | Cervix | CC |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | Cervix | CC |
BMP7 | BMPR1B_ACVR2A | BMP7_BMPR1B_ACVR2A | BMP | Cervix | CC |
BMP7 | BMPR1B_BMPR2 | BMP7_BMPR1B_BMPR2 | BMP | Cervix | CC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Endometrium | AEH |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | Endometrium | AEH |
BMP7 | BMPR1B_BMPR2 | BMP7_BMPR1B_BMPR2 | BMP | Endometrium | AEH |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Esophagus | ESCC |
BMP7 | BMPR1A_ACVR2B | BMP7_BMPR1A_ACVR2B | BMP | Esophagus | ESCC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | HNSCC | OSCC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | HNSCC | Precancer |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | HNSCC | Precancer |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | THCA | ADJ |
BMP7 | BMPR1A_ACVR2A | BMP7_BMPR1A_ACVR2A | BMP | THCA | ADJ |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | THCA | ADJ |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | THCA | PTC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMP7 | insertion | In_Frame_Ins | novel | c.868_869insAACCAAAGCTTCAAATAATGAACCTCACAACAAACCATT | p.Ser290delinsLysProLysLeuGlnIleMetAsnLeuThrThrAsnHisCys | p.S290delinsKPKLQIMNLTTNHC | P18075 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BMP7 | insertion | Frame_Shift_Ins | novel | c.1044_1045insT | p.Ile349TyrfsTer4 | p.I349Yfs*4 | P18075 | protein_coding | TCGA-BH-A0GY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyotxan | SD | ||
BMP7 | deletion | Frame_Shift_Del | novel | c.237delN | p.Met81CysfsTer54 | p.M81Cfs*54 | P18075 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
BMP7 | SNV | Missense_Mutation | rs201575559 | c.449N>A | p.Arg150His | p.R150H | P18075 | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BMP7 | SNV | Missense_Mutation | c.517N>A | p.Glu173Lys | p.E173K | P18075 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BMP7 | SNV | Missense_Mutation | novel | c.1290N>G | p.Cys430Trp | p.C430W | P18075 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3850-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
BMP7 | SNV | Missense_Mutation | c.517N>A | p.Glu173Lys | p.E173K | P18075 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BMP7 | SNV | Missense_Mutation | c.391N>A | p.Asp131Asn | p.D131N | P18075 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BMP7 | SNV | Missense_Mutation | rs149261355 | c.556G>A | p.Asp186Asn | p.D186N | P18075 | protein_coding | tolerated(0.43) | benign(0.015) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BMP7 | SNV | Missense_Mutation | rs772689429 | c.1000G>A | p.Glu334Lys | p.E334K | P18075 | protein_coding | deleterious(0) | benign(0.325) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | pegaspargase | PEGASPARGASE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | methotrexate | METHOTREXATE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | cyclophosphamide | CYCLOPHOSPHAMIDE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | thioguanine | THIOGUANINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | prednisone | PREDNISONE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | dexamethasone | DEXAMETHASONE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | cytarabine | CYTARABINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | vincristine | VINCRISTINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | daunorubicin | DAUNORUBICIN | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | doxorubicin | DOXORUBICIN | 26590194 |
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