Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000914128 | Thyroid | ATC | nucleoside triphosphate metabolic process | 63/6293 | 112/18723 | 6.90e-07 | 9.35e-06 | 63 |
GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
GO:000920527 | Thyroid | ATC | purine ribonucleoside triphosphate metabolic process | 49/6293 | 82/18723 | 1.07e-06 | 1.39e-05 | 49 |
GO:000616328 | Thyroid | ATC | purine nucleotide metabolic process | 177/6293 | 396/18723 | 2.39e-06 | 2.82e-05 | 177 |
GO:000919926 | Thyroid | ATC | ribonucleoside triphosphate metabolic process | 51/6293 | 89/18723 | 3.72e-06 | 4.12e-05 | 51 |
GO:000914527 | Thyroid | ATC | purine nucleoside triphosphate biosynthetic process | 41/6293 | 69/18723 | 9.68e-06 | 9.67e-05 | 41 |
GO:000915225 | Thyroid | ATC | purine ribonucleotide biosynthetic process | 84/6293 | 169/18723 | 1.05e-05 | 1.04e-04 | 84 |
GO:0009185111 | Thyroid | ATC | ribonucleoside diphosphate metabolic process | 57/6293 | 106/18723 | 1.48e-05 | 1.39e-04 | 57 |
GO:001931814 | Thyroid | ATC | hexose metabolic process | 111/6293 | 237/18723 | 1.51e-05 | 1.41e-04 | 111 |
GO:004639025 | Thyroid | ATC | ribose phosphate biosynthetic process | 92/6293 | 190/18723 | 1.57e-05 | 1.46e-04 | 92 |
GO:000920627 | Thyroid | ATC | purine ribonucleoside triphosphate biosynthetic process | 40/6293 | 68/18723 | 1.74e-05 | 1.59e-04 | 40 |
GO:000926025 | Thyroid | ATC | ribonucleotide biosynthetic process | 88/6293 | 182/18723 | 2.55e-05 | 2.20e-04 | 88 |
GO:000599615 | Thyroid | ATC | monosaccharide metabolic process | 118/6293 | 257/18723 | 2.56e-05 | 2.20e-04 | 118 |
GO:0009132111 | Thyroid | ATC | nucleoside diphosphate metabolic process | 64/6293 | 124/18723 | 2.59e-05 | 2.22e-04 | 64 |
GO:0009135112 | Thyroid | ATC | purine nucleoside diphosphate metabolic process | 55/6293 | 103/18723 | 2.70e-05 | 2.30e-04 | 55 |
GO:0009179112 | Thyroid | ATC | purine ribonucleoside diphosphate metabolic process | 55/6293 | 103/18723 | 2.70e-05 | 2.30e-04 | 55 |
GO:000914227 | Thyroid | ATC | nucleoside triphosphate biosynthetic process | 47/6293 | 85/18723 | 3.16e-05 | 2.63e-04 | 47 |
GO:004603126 | Thyroid | ATC | ADP metabolic process | 49/6293 | 90/18723 | 3.74e-05 | 3.05e-04 | 49 |
GO:000675426 | Thyroid | ATC | ATP biosynthetic process | 34/6293 | 57/18723 | 4.91e-05 | 3.90e-04 | 34 |
GO:000920126 | Thyroid | ATC | ribonucleoside triphosphate biosynthetic process | 41/6293 | 74/18723 | 9.32e-05 | 6.84e-04 | 41 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa01230 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa012301 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa012002 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa040662 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
hsa000102 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
hsa012302 | Colorectum | SER | Biosynthesis of amino acids | 23/1580 | 75/8465 | 8.11e-03 | 4.14e-02 | 3.01e-02 | 23 |
hsa012003 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa040663 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
hsa000103 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
hsa012303 | Colorectum | SER | Biosynthesis of amino acids | 23/1580 | 75/8465 | 8.11e-03 | 4.14e-02 | 3.01e-02 | 23 |
hsa012004 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa000104 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa040664 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa012005 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa000105 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa040665 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALDOA | SNV | Missense_Mutation | | c.641C>T | p.Ser214Leu | p.S214L | P04075 | protein_coding | deleterious(0) | possibly_damaging(0.833) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ALDOA | SNV | Missense_Mutation | | c.987G>C | p.Gln329His | p.Q329H | P04075 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
ALDOA | SNV | Missense_Mutation | | c.490N>C | p.Asp164His | p.D164H | P04075 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
ALDOA | SNV | Missense_Mutation | | c.562N>G | p.Arg188Gly | p.R188G | P04075 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-BH-A0HL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
ALDOA | SNV | Missense_Mutation | rs201658390 | c.929C>T | p.Ala310Val | p.A310V | P04075 | protein_coding | tolerated(0.12) | benign(0.091) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALDOA | SNV | Missense_Mutation | | c.817N>A | p.Asp273Asn | p.D273N | P04075 | protein_coding | deleterious(0) | benign(0.036) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALDOA | insertion | Frame_Shift_Ins | novel | c.678_679insT | p.Arg227SerfsTer18 | p.R227Sfs*18 | P04075 | protein_coding | | | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ALDOA | insertion | Nonsense_Mutation | novel | c.679_680insTCAGAAGCTCAGGGAAGTGAAGT | p.Arg227LeufsTer7 | p.R227Lfs*7 | P04075 | protein_coding | | | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ALDOA | insertion | Nonsense_Mutation | novel | c.1253_1254insGAGTCCACTGGTGCGGGCAGGAGACAGAATGGG | p.Tyr418delinsTer | p.Y418delins* | P04075 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
ALDOA | SNV | Missense_Mutation | rs756789043 | c.1249G>A | p.Ala417Thr | p.A417T | P04075 | protein_coding | tolerated(0.18) | possibly_damaging(0.868) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |