GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004339324 | Skin | AK | regulation of protein binding | 36/1910 | 196/18723 | 3.52e-04 | 3.50e-03 | 36 |
GO:003582110 | Skin | AK | modulation of process of other organism | 23/1910 | 106/18723 | 3.64e-04 | 3.59e-03 | 23 |
GO:000717817 | Skin | AK | transmembrane receptor protein serine/threonine kinase signaling pathway | 57/1910 | 355/18723 | 3.69e-04 | 3.61e-03 | 57 |
GO:000268317 | Skin | AK | negative regulation of immune system process | 67/1910 | 434/18723 | 3.74e-04 | 3.63e-03 | 67 |
GO:003166727 | Skin | AK | response to nutrient levels | 72/1910 | 474/18723 | 3.74e-04 | 3.63e-03 | 72 |
GO:00991737 | Skin | AK | postsynapse organization | 32/1910 | 168/18723 | 3.77e-04 | 3.65e-03 | 32 |
GO:006101417 | Skin | AK | positive regulation of mRNA catabolic process | 20/1910 | 87/18723 | 3.90e-04 | 3.74e-03 | 20 |
GO:00425525 | Skin | AK | myelination | 27/1910 | 134/18723 | 4.20e-04 | 4.00e-03 | 27 |
GO:00183946 | Skin | AK | peptidyl-lysine acetylation | 32/1910 | 169/18723 | 4.20e-04 | 4.00e-03 | 32 |
GO:001908018 | Skin | AK | viral gene expression | 21/1910 | 94/18723 | 4.26e-04 | 4.05e-03 | 21 |
GO:00022447 | Skin | AK | hematopoietic progenitor cell differentiation | 24/1910 | 114/18723 | 4.40e-04 | 4.13e-03 | 24 |
GO:005077917 | Skin | AK | RNA destabilization | 20/1910 | 88/18723 | 4.57e-04 | 4.27e-03 | 20 |
GO:00435436 | Skin | AK | protein acylation | 42/1910 | 243/18723 | 4.59e-04 | 4.28e-03 | 42 |
GO:00028319 | Skin | AK | regulation of response to biotic stimulus | 53/1910 | 327/18723 | 4.63e-04 | 4.31e-03 | 53 |
GO:000020918 | Skin | AK | protein polyubiquitination | 41/1910 | 236/18723 | 4.78e-04 | 4.44e-03 | 41 |
GO:00085936 | Skin | AK | regulation of Notch signaling pathway | 21/1910 | 95/18723 | 4.96e-04 | 4.58e-03 | 21 |
GO:007135624 | Skin | AK | cellular response to tumor necrosis factor | 40/1910 | 229/18723 | 4.98e-04 | 4.58e-03 | 40 |
GO:000698417 | Skin | AK | ER-nucleus signaling pathway | 13/1910 | 46/18723 | 5.02e-04 | 4.61e-03 | 13 |
GO:00315719 | Skin | AK | mitotic G1 DNA damage checkpoint | 10/1910 | 30/18723 | 5.26e-04 | 4.79e-03 | 10 |
GO:00447889 | Skin | AK | modulation by host of viral process | 10/1910 | 30/18723 | 5.26e-04 | 4.79e-03 | 10 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517114 | Liver | NAFLD | Coronavirus disease - COVID-19 | 111/1043 | 232/8465 | 1.01e-41 | 3.32e-39 | 2.67e-39 | 111 |
hsa04610 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa0513014 | Liver | NAFLD | Pathogenic Escherichia coli infection | 45/1043 | 197/8465 | 2.31e-05 | 6.88e-04 | 5.54e-04 | 45 |
hsa0481010 | Liver | NAFLD | Regulation of actin cytoskeleton | 50/1043 | 229/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 50 |
hsa0517115 | Liver | NAFLD | Coronavirus disease - COVID-19 | 111/1043 | 232/8465 | 1.01e-41 | 3.32e-39 | 2.67e-39 | 111 |
hsa046101 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa0513015 | Liver | NAFLD | Pathogenic Escherichia coli infection | 45/1043 | 197/8465 | 2.31e-05 | 6.88e-04 | 5.54e-04 | 45 |
hsa0481011 | Liver | NAFLD | Regulation of actin cytoskeleton | 50/1043 | 229/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 50 |
hsa0517122 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0513022 | Liver | Cirrhotic | Pathogenic Escherichia coli infection | 88/2530 | 197/8465 | 6.48e-06 | 6.24e-05 | 3.84e-05 | 88 |
hsa0517132 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0513032 | Liver | Cirrhotic | Pathogenic Escherichia coli infection | 88/2530 | 197/8465 | 6.48e-06 | 6.24e-05 | 3.84e-05 | 88 |
hsa0517142 | Liver | HCC | Coronavirus disease - COVID-19 | 167/4020 | 232/8465 | 1.50e-14 | 4.19e-13 | 2.33e-13 | 167 |
hsa0513042 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F2 | SNV | Missense_Mutation | novel | c.1390N>T | p.Ala464Ser | p.A464S | P00734 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B6-A0RL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
F2 | SNV | Missense_Mutation | rs121918482 | c.1292N>A | p.Arg431His | p.R431H | P00734 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F2 | SNV | Missense_Mutation | | c.448N>T | p.Ala150Ser | p.A150S | P00734 | protein_coding | tolerated(0.47) | benign(0.06) | TCGA-E2-A15S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
F2 | insertion | In_Frame_Ins | novel | c.1074_1075insACCCAGCATGAGCTTTCCTGGGATTACTCATAT | p.Ser358_Tyr359insThrGlnHisGluLeuSerTrpAspTyrSerTyr | p.S358_Y359insTQHELSWDYSY | P00734 | protein_coding | | | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
F2 | deletion | Frame_Shift_Del | | c.1015_1025delNNNNNNNNNNN | p.Pro340GlufsTer55 | p.P340Efs*55 | P00734 | protein_coding | | | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
F2 | deletion | Frame_Shift_Del | novel | c.204delN | p.Glu69ArgfsTer52 | p.E69Rfs*52 | P00734 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
F2 | SNV | Missense_Mutation | rs144785536 | c.103C>T | p.Arg35Trp | p.R35W | P00734 | protein_coding | tolerated(0.11) | benign(0.093) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
F2 | SNV | Missense_Mutation | novel | c.1755N>T | p.Met585Ile | p.M585I | P00734 | protein_coding | tolerated(0.47) | benign(0.011) | TCGA-EK-A2RE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
F2 | SNV | Missense_Mutation | novel | c.225N>C | p.Glu75Asp | p.E75D | P00734 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
F2 | SNV | Missense_Mutation | rs775306348 | c.5C>T | p.Ala2Val | p.A2V | P00734 | protein_coding | tolerated_low_confidence(0.14) | benign(0.01) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | Anisindione | ANISINDIONE | |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | LEPIRUDIN | LEPIRUDIN | |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | ATryn antithrombin | | 24391399 |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | (-)-EPICATECHIN | (-)-EPICATECHIN | |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | hormonal contraceptives for systemic use | | 15208046,28750087,12069454,16769590 |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | Odiparcil | ODIPARCIL | |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | QUERCETIN | QUERCETIN | |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | AZD-0837 | ATECEGATRAN METOXIL | |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | | Hirudin | | |
2147 | F2 | PROTEASE, EXTERNAL SIDE OF PLASMA MEMBRANE, GROWTH FACTOR, DRUGGABLE GENOME, ENZYME | inhibitor | 178102998 | DABIGATRAN | |