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Gene: SLC25A5 |
Gene summary for SLC25A5 |
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Gene information | Species | Human | Gene symbol | SLC25A5 | Gene ID | 292 |
Gene name | solute carrier family 25 member 5 | |
Gene Alias | 2F1 | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0000422 | UniProtAcc | P05141 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
292 | SLC25A5 | GSM4909282 | Human | Breast | IDC | 1.72e-91 | 7.74e-01 | -0.0288 |
292 | SLC25A5 | GSM4909285 | Human | Breast | IDC | 3.62e-33 | 5.55e-01 | 0.21 |
292 | SLC25A5 | GSM4909286 | Human | Breast | IDC | 1.46e-08 | -1.30e-01 | 0.1081 |
292 | SLC25A5 | GSM4909287 | Human | Breast | IDC | 4.02e-02 | -2.84e-01 | 0.2057 |
292 | SLC25A5 | GSM4909292 | Human | Breast | IDC | 5.48e-05 | -7.79e-01 | 0.1236 |
292 | SLC25A5 | GSM4909293 | Human | Breast | IDC | 2.49e-12 | -3.55e-01 | 0.1581 |
292 | SLC25A5 | GSM4909294 | Human | Breast | IDC | 1.36e-10 | -2.46e-01 | 0.2022 |
292 | SLC25A5 | GSM4909296 | Human | Breast | IDC | 2.82e-23 | 1.29e-01 | 0.1524 |
292 | SLC25A5 | GSM4909297 | Human | Breast | IDC | 1.29e-29 | -3.74e-01 | 0.1517 |
292 | SLC25A5 | GSM4909298 | Human | Breast | IDC | 6.78e-10 | -2.90e-01 | 0.1551 |
292 | SLC25A5 | GSM4909301 | Human | Breast | IDC | 7.92e-15 | -4.64e-01 | 0.1577 |
292 | SLC25A5 | GSM4909302 | Human | Breast | IDC | 2.02e-03 | -2.79e-01 | 0.1545 |
292 | SLC25A5 | GSM4909306 | Human | Breast | IDC | 6.88e-04 | 2.85e-01 | 0.1564 |
292 | SLC25A5 | GSM4909308 | Human | Breast | IDC | 7.66e-04 | 3.00e-01 | 0.158 |
292 | SLC25A5 | GSM4909309 | Human | Breast | IDC | 2.93e-04 | -2.76e-01 | 0.0483 |
292 | SLC25A5 | GSM4909311 | Human | Breast | IDC | 5.42e-60 | -5.35e-01 | 0.1534 |
292 | SLC25A5 | GSM4909312 | Human | Breast | IDC | 1.79e-14 | -6.07e-04 | 0.1552 |
292 | SLC25A5 | GSM4909313 | Human | Breast | IDC | 1.12e-02 | -2.08e-01 | 0.0391 |
292 | SLC25A5 | GSM4909315 | Human | Breast | IDC | 1.57e-14 | -4.73e-01 | 0.21 |
292 | SLC25A5 | GSM4909316 | Human | Breast | IDC | 7.80e-05 | -4.13e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896113 | Thyroid | PTC | positive regulation of catabolic process | 278/5968 | 492/18723 | 3.35e-30 | 2.64e-27 | 278 |
GO:0031331113 | Thyroid | PTC | positive regulation of cellular catabolic process | 249/5968 | 427/18723 | 5.28e-30 | 3.58e-27 | 249 |
GO:2001233113 | Thyroid | PTC | regulation of apoptotic signaling pathway | 197/5968 | 356/18723 | 2.58e-20 | 3.69e-18 | 197 |
GO:0022411113 | Thyroid | PTC | cellular component disassembly | 232/5968 | 443/18723 | 1.36e-19 | 1.75e-17 | 232 |
GO:0016236110 | Thyroid | PTC | macroautophagy | 167/5968 | 291/18723 | 1.51e-19 | 1.91e-17 | 167 |
GO:000683928 | Thyroid | PTC | mitochondrial transport | 150/5968 | 254/18723 | 2.76e-19 | 3.34e-17 | 150 |
GO:0010506110 | Thyroid | PTC | regulation of autophagy | 172/5968 | 317/18723 | 8.76e-17 | 7.57e-15 | 172 |
GO:2001234113 | Thyroid | PTC | negative regulation of apoptotic signaling pathway | 124/5968 | 224/18723 | 2.57e-13 | 1.32e-11 | 124 |
GO:190300818 | Thyroid | PTC | organelle disassembly | 73/5968 | 114/18723 | 1.60e-12 | 7.12e-11 | 73 |
GO:0015931110 | Thyroid | PTC | nucleobase-containing compound transport | 120/5968 | 222/18723 | 5.45e-12 | 2.35e-10 | 120 |
GO:001624110 | Thyroid | PTC | regulation of macroautophagy | 84/5968 | 141/18723 | 1.04e-11 | 4.27e-10 | 84 |
GO:0000422110 | Thyroid | PTC | autophagy of mitochondrion | 55/5968 | 81/18723 | 2.95e-11 | 1.10e-09 | 55 |
GO:0061726110 | Thyroid | PTC | mitochondrion disassembly | 55/5968 | 81/18723 | 2.95e-11 | 1.10e-09 | 55 |
GO:000700624 | Thyroid | PTC | mitochondrial membrane organization | 68/5968 | 116/18723 | 2.47e-09 | 6.88e-08 | 68 |
GO:0010639112 | Thyroid | PTC | negative regulation of organelle organization | 163/5968 | 348/18723 | 3.04e-09 | 8.39e-08 | 163 |
GO:001050810 | Thyroid | PTC | positive regulation of autophagy | 70/5968 | 124/18723 | 1.30e-08 | 3.08e-07 | 70 |
GO:001082124 | Thyroid | PTC | regulation of mitochondrion organization | 78/5968 | 144/18723 | 2.38e-08 | 5.43e-07 | 78 |
GO:190314616 | Thyroid | PTC | regulation of autophagy of mitochondrion | 25/5968 | 33/18723 | 2.82e-07 | 4.86e-06 | 25 |
GO:0034101113 | Thyroid | PTC | erythrocyte homeostasis | 69/5968 | 129/18723 | 2.85e-07 | 4.90e-06 | 69 |
GO:199054225 | Thyroid | PTC | mitochondrial transmembrane transport | 57/5968 | 102/18723 | 4.49e-07 | 7.38e-06 | 57 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501714 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa042189 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0516618 | Breast | Precancer | Human T-cell leukemia virus 1 infection | 33/684 | 222/8465 | 4.29e-04 | 3.31e-03 | 2.53e-03 | 33 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501715 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0421814 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0516619 | Breast | Precancer | Human T-cell leukemia virus 1 infection | 33/684 | 222/8465 | 4.29e-04 | 3.31e-03 | 2.53e-03 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A5 | insertion | Frame_Shift_Ins | novel | c.249_250insA | p.Thr84AsnfsTer5 | p.T84Nfs*5 | P05141 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC25A5 | SNV | Missense_Mutation | novel | c.618N>T | p.Lys206Asn | p.K206N | P05141 | protein_coding | deleterious(0.05) | benign(0.033) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC25A5 | SNV | Missense_Mutation | c.858N>G | p.Phe286Leu | p.F286L | P05141 | protein_coding | tolerated(1) | benign(0.003) | TCGA-C5-A2M2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC25A5 | SNV | Missense_Mutation | novel | c.839N>A | p.Arg280Lys | p.R280K | P05141 | protein_coding | deleterious(0.01) | possibly_damaging(0.532) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
SLC25A5 | SNV | Missense_Mutation | c.439N>G | p.Lys147Glu | p.K147E | P05141 | protein_coding | deleterious(0) | possibly_damaging(0.488) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
SLC25A5 | SNV | Missense_Mutation | c.317G>T | p.Arg106Ile | p.R106I | P05141 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
SLC25A5 | SNV | Missense_Mutation | c.91N>T | p.Arg31Trp | p.R31W | P05141 | protein_coding | tolerated(0.09) | benign(0.209) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
SLC25A5 | SNV | Missense_Mutation | c.703N>T | p.Arg235Cys | p.R235C | P05141 | protein_coding | deleterious(0.05) | possibly_damaging(0.835) | TCGA-D5-6541-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC25A5 | SNV | Missense_Mutation | novel | c.288N>T | p.Lys96Asn | p.K96N | P05141 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC25A5 | SNV | Missense_Mutation | c.703C>T | p.Arg235Cys | p.R235C | P05141 | protein_coding | deleterious(0.05) | possibly_damaging(0.835) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
292 | SLC25A5 | DRUGGABLE GENOME, TRANSPORTER | CLODRONATE | CLODRONIC ACID | ||
292 | SLC25A5 | DRUGGABLE GENOME, TRANSPORTER | TRICHOSTATIN A | 10657244 | ||
292 | SLC25A5 | DRUGGABLE GENOME, TRANSPORTER | BUTYRATE | 10657244 |
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