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Gene: HP |
Gene summary for HP |
Gene summary. |
Gene information | Species | Human | Gene symbol | HP | Gene ID | 3240 |
Gene name | haptoglobin | |
Gene Alias | BP | |
Cytomap | 16q22.2 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P00738 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3240 | HP | NAFLD1 | Human | Liver | NAFLD | 1.17e-13 | 6.11e-01 | -0.04 |
3240 | HP | S43 | Human | Liver | Cirrhotic | 3.13e-22 | 9.97e-01 | -0.0187 |
3240 | HP | S44 | Human | Liver | HCC | 1.37e-05 | 1.27e+00 | -0.0083 |
3240 | HP | HCC1_Meng | Human | Liver | HCC | 1.73e-44 | -2.90e-01 | 0.0246 |
3240 | HP | HCC2_Meng | Human | Liver | HCC | 2.37e-21 | -7.46e-01 | 0.0107 |
3240 | HP | cirrhotic1 | Human | Liver | Cirrhotic | 2.90e-08 | -4.39e-01 | 0.0202 |
3240 | HP | cirrhotic2 | Human | Liver | Cirrhotic | 2.47e-17 | -2.31e-01 | 0.0201 |
3240 | HP | HCC1 | Human | Liver | HCC | 2.12e-30 | 7.24e+00 | 0.5336 |
3240 | HP | HCC2 | Human | Liver | HCC | 3.26e-37 | 8.39e+00 | 0.5341 |
3240 | HP | Pt13.a | Human | Liver | HCC | 2.41e-98 | 1.32e+00 | 0.021 |
3240 | HP | Pt13.b | Human | Liver | HCC | 4.73e-94 | 1.17e+00 | 0.0251 |
3240 | HP | Pt13.c | Human | Liver | HCC | 6.36e-69 | 1.56e+00 | 0.0076 |
3240 | HP | Pt14.b | Human | Liver | HCC | 5.05e-20 | 6.19e-01 | 0.018 |
3240 | HP | Pt14.d | Human | Liver | HCC | 6.00e-20 | 2.11e-01 | 0.0143 |
3240 | HP | S016 | Human | Liver | HCC | 1.72e-09 | -6.26e-01 | 0.2243 |
3240 | HP | S027 | Human | Liver | HCC | 9.81e-49 | 5.21e-01 | 0.2446 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315329 | Endometrium | AEH | actin cytoskeleton reorganization | 32/2100 | 107/18723 | 1.24e-07 | 5.80e-06 | 32 |
GO:011005316 | Endometrium | AEH | regulation of actin filament organization | 61/2100 | 278/18723 | 1.83e-07 | 8.11e-06 | 61 |
GO:007132210 | Endometrium | AEH | cellular response to carbohydrate stimulus | 41/2100 | 163/18723 | 4.55e-07 | 1.87e-05 | 41 |
GO:19048724 | Endometrium | AEH | regulation of telomerase RNA localization to Cajal body | 11/2100 | 18/18723 | 5.17e-07 | 2.01e-05 | 11 |
GO:19048744 | Endometrium | AEH | positive regulation of telomerase RNA localization to Cajal body | 10/2100 | 15/18723 | 5.44e-07 | 2.10e-05 | 10 |
GO:003103210 | Endometrium | AEH | actomyosin structure organization | 46/2100 | 196/18723 | 8.00e-07 | 2.91e-05 | 46 |
GO:00906704 | Endometrium | AEH | RNA localization to Cajal body | 11/2100 | 19/18723 | 1.10e-06 | 3.68e-05 | 11 |
GO:00906714 | Endometrium | AEH | telomerase RNA localization to Cajal body | 11/2100 | 19/18723 | 1.10e-06 | 3.68e-05 | 11 |
GO:00906724 | Endometrium | AEH | telomerase RNA localization | 11/2100 | 19/18723 | 1.10e-06 | 3.68e-05 | 11 |
GO:00906854 | Endometrium | AEH | RNA localization to nucleus | 11/2100 | 19/18723 | 1.10e-06 | 3.68e-05 | 11 |
GO:00713339 | Endometrium | AEH | cellular response to glucose stimulus | 38/2100 | 151/18723 | 1.17e-06 | 3.82e-05 | 38 |
GO:005101716 | Endometrium | AEH | actin filament bundle assembly | 39/2100 | 157/18723 | 1.21e-06 | 3.91e-05 | 39 |
GO:00713319 | Endometrium | AEH | cellular response to hexose stimulus | 38/2100 | 153/18723 | 1.65e-06 | 5.13e-05 | 38 |
GO:004259310 | Endometrium | AEH | glucose homeostasis | 55/2100 | 258/18723 | 1.87e-06 | 5.74e-05 | 55 |
GO:00713269 | Endometrium | AEH | cellular response to monosaccharide stimulus | 38/2100 | 154/18723 | 1.96e-06 | 5.93e-05 | 38 |
GO:003350010 | Endometrium | AEH | carbohydrate homeostasis | 55/2100 | 259/18723 | 2.12e-06 | 6.31e-05 | 55 |
GO:006157216 | Endometrium | AEH | actin filament bundle organization | 39/2100 | 161/18723 | 2.36e-06 | 6.86e-05 | 39 |
GO:19029049 | Endometrium | AEH | negative regulation of supramolecular fiber organization | 39/2100 | 167/18723 | 6.07e-06 | 1.50e-04 | 39 |
GO:003223115 | Endometrium | AEH | regulation of actin filament bundle assembly | 28/2100 | 105/18723 | 8.87e-06 | 2.09e-04 | 28 |
GO:003003815 | Endometrium | AEH | contractile actin filament bundle assembly | 28/2100 | 106/18723 | 1.08e-05 | 2.45e-04 | 28 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HP | SNV | Missense_Mutation | novel | c.593T>A | p.Leu198Gln | p.L198Q | P00738 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HP | insertion | Nonsense_Mutation | novel | c.594_595insTTTTAA | p.Leu198_Thr199insPheTer | p.L198_T199insF* | P00738 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HP | insertion | Frame_Shift_Ins | novel | c.593_594insTCTTGCCCAAATTCAG | p.Thr199LeufsTer9 | p.T199Lfs*9 | P00738 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
HP | insertion | Frame_Shift_Ins | novel | c.125_126insA | p.Tyr43LeufsTer11 | p.Y43Lfs*11 | P00738 | protein_coding | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
HP | insertion | In_Frame_Ins | novel | c.127_128insCAGGCA | p.Tyr43delinsSerGlyAsn | p.Y43delinsSGN | P00738 | protein_coding | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
HP | SNV | Missense_Mutation | novel | c.218A>C | p.Gln73Pro | p.Q73P | P00738 | protein_coding | tolerated(0.17) | benign(0.278) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HP | SNV | Missense_Mutation | novel | c.1153N>C | p.Glu385Gln | p.E385Q | P00738 | protein_coding | tolerated(0.09) | possibly_damaging(0.624) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
HP | SNV | Missense_Mutation | c.91G>A | p.Asp31Asn | p.D31N | P00738 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.709) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
HP | SNV | Missense_Mutation | c.140C>T | p.Ser47Leu | p.S47L | P00738 | protein_coding | tolerated(0.23) | benign(0) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HP | SNV | Missense_Mutation | c.791N>A | p.Pro264His | p.P264H | P00738 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | HEPATITIS B VACCINE | 8256500 | ||
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | 17 BETA-ESTRADIOL | 2078644 | ||
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | PYRIDOXINE | PYRIDOXINE | 6935482 | |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | AT1001 | 22731712 | ||
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | STREPTOZOTOCIN | STREPTOZOCIN | 16713232 | |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | VACCINE | 8228935 |
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