Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005122216 | Endometrium | EEC | positive regulation of protein transport | 66/2168 | 303/18723 | 2.55e-07 | 1.09e-05 | 66 |
GO:009719117 | Endometrium | EEC | extrinsic apoptotic signaling pathway | 52/2168 | 219/18723 | 2.91e-07 | 1.20e-05 | 52 |
GO:005109917 | Endometrium | EEC | positive regulation of binding | 44/2168 | 173/18723 | 3.08e-07 | 1.27e-05 | 44 |
GO:200123617 | Endometrium | EEC | regulation of extrinsic apoptotic signaling pathway | 40/2168 | 151/18723 | 3.33e-07 | 1.33e-05 | 40 |
GO:000716014 | Endometrium | EEC | cell-matrix adhesion | 54/2168 | 233/18723 | 3.98e-07 | 1.56e-05 | 54 |
GO:006056013 | Endometrium | EEC | developmental growth involved in morphogenesis | 54/2168 | 234/18723 | 4.60e-07 | 1.78e-05 | 54 |
GO:000740912 | Endometrium | EEC | axonogenesis | 82/2168 | 418/18723 | 1.03e-06 | 3.49e-05 | 82 |
GO:006082813 | Endometrium | EEC | regulation of canonical Wnt signaling pathway | 56/2168 | 253/18723 | 1.18e-06 | 3.90e-05 | 56 |
GO:004325417 | Endometrium | EEC | regulation of protein-containing complex assembly | 83/2168 | 428/18723 | 1.44e-06 | 4.64e-05 | 83 |
GO:004339315 | Endometrium | EEC | regulation of protein binding | 46/2168 | 196/18723 | 1.94e-06 | 5.80e-05 | 46 |
GO:003315715 | Endometrium | EEC | regulation of intracellular protein transport | 51/2168 | 229/18723 | 2.89e-06 | 8.09e-05 | 51 |
GO:000661114 | Endometrium | EEC | protein export from nucleus | 20/2168 | 57/18723 | 2.96e-06 | 8.25e-05 | 20 |
GO:190121617 | Endometrium | EEC | positive regulation of neuron death | 28/2168 | 97/18723 | 3.08e-06 | 8.48e-05 | 28 |
GO:004346714 | Endometrium | EEC | regulation of generation of precursor metabolites and energy | 34/2168 | 130/18723 | 3.36e-06 | 9.13e-05 | 34 |
GO:003133417 | Endometrium | EEC | positive regulation of protein-containing complex assembly | 52/2168 | 237/18723 | 3.68e-06 | 9.90e-05 | 52 |
GO:003001014 | Endometrium | EEC | establishment of cell polarity | 36/2168 | 143/18723 | 4.57e-06 | 1.15e-04 | 36 |
GO:003238815 | Endometrium | EEC | positive regulation of intracellular transport | 46/2168 | 202/18723 | 4.64e-06 | 1.16e-04 | 46 |
GO:003450413 | Endometrium | EEC | protein localization to nucleus | 60/2168 | 290/18723 | 5.09e-06 | 1.26e-04 | 60 |
GO:190305215 | Endometrium | EEC | positive regulation of proteolysis involved in cellular protein catabolic process | 34/2168 | 133/18723 | 5.80e-06 | 1.41e-04 | 34 |
GO:003238613 | Endometrium | EEC | regulation of intracellular transport | 67/2168 | 337/18723 | 6.13e-06 | 1.48e-04 | 67 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSK3B | SNV | Missense_Mutation | | c.46N>T | p.Pro16Ser | p.P16S | P49841 | protein_coding | tolerated_low_confidence(0.36) | benign(0.003) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSK3B | SNV | Missense_Mutation | novel | c.857C>G | p.Pro286Arg | p.P286R | P49841 | protein_coding | deleterious(0.03) | benign(0.162) | TCGA-C8-A8HR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
GSK3B | insertion | Nonsense_Mutation | novel | c.1146_1147insGAAACCGGGAGGCGGAGGTTGCATTGAGCCGAGATTGCGCC | p.Asn383GlufsTer9 | p.N383Efs*9 | P49841 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
GSK3B | insertion | In_Frame_Ins | novel | c.44_45insATCACAAGGAGAACTCTGTTTTGA | p.Lys15_Pro16insSerGlnGlyGluLeuCysPheGlu | p.K15_P16insSQGELCFE | P49841 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSK3B | deletion | Frame_Shift_Del | novel | c.850delN | p.Met284Ter | p.M284* | P49841 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
GSK3B | SNV | Missense_Mutation | novel | c.259G>A | p.Val87Ile | p.V87I | P49841 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GSK3B | SNV | Missense_Mutation | novel | c.683N>A | p.Ile228Asn | p.I228N | P49841 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GSK3B | SNV | Missense_Mutation | rs72548709 | c.995N>A | p.Arg332His | p.R332H | P49841 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GSK3B | SNV | Missense_Mutation | | c.713N>C | p.Ile238Thr | p.I238T | P49841 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GSK3B | SNV | Missense_Mutation | | c.901T>C | p.Trp301Arg | p.W301R | P49841 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | | PMID26161698-Compound-18 | | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | | Neu-120 | | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | | SOTRASTAURIN | SOTRASTAURIN | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | | CYC-116 | CYC-116 | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | | tideglusib | TIDEGLUSIB | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | inhibitor | 404859135 | | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | | ALSTERPAULLONE | ALSTERPAULLONE | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | inhibitor | CHEMBL1200826 | LITHIUM CARBONATE | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | | AMO-02 | | |
2932 | GSK3B | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME, CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR | | BETULINIC ACID | BETULINIC ACID | 19716700 |