Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/EIF6_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/EIF6_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/EIF6_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/EIF6_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/EIF6_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/EIF6_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/EIF6_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/EIF6_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/EIF6_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/EIF6_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/EIF6_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005116811 | Stomach | CAG with IM | nuclear export | 19/1050 | 154/18723 | 1.02e-03 | 1.29e-02 | 19 |
GO:000641711 | Stomach | CAG with IM | regulation of translation | 43/1050 | 468/18723 | 1.03e-03 | 1.29e-02 | 43 |
GO:004343411 | Stomach | CAG with IM | response to peptide hormone | 39/1050 | 414/18723 | 1.09e-03 | 1.33e-02 | 39 |
GO:200037711 | Stomach | CAG with IM | regulation of reactive oxygen species metabolic process | 19/1050 | 157/18723 | 1.29e-03 | 1.53e-02 | 19 |
GO:004639411 | Stomach | CAG with IM | carboxylic acid biosynthetic process | 31/1050 | 314/18723 | 1.63e-03 | 1.80e-02 | 31 |
GO:001605311 | Stomach | CAG with IM | organic acid biosynthetic process | 31/1050 | 316/18723 | 1.81e-03 | 1.94e-02 | 31 |
GO:000609011 | Stomach | CAG with IM | pyruvate metabolic process | 14/1050 | 106/18723 | 2.38e-03 | 2.36e-02 | 14 |
GO:00421801 | Stomach | CAG with IM | cellular ketone metabolic process | 22/1050 | 211/18723 | 3.81e-03 | 3.35e-02 | 22 |
GO:00723301 | Stomach | CAG with IM | monocarboxylic acid biosynthetic process | 22/1050 | 214/18723 | 4.51e-03 | 3.77e-02 | 22 |
GO:00423041 | Stomach | CAG with IM | regulation of fatty acid biosynthetic process | 8/1050 | 49/18723 | 5.53e-03 | 4.35e-02 | 8 |
GO:00069136 | Stomach | CAG with IM | nucleocytoplasmic transport | 28/1050 | 301/18723 | 6.09e-03 | 4.68e-02 | 28 |
GO:00511696 | Stomach | CAG with IM | nuclear transport | 28/1050 | 301/18723 | 6.09e-03 | 4.68e-02 | 28 |
GO:0000054 | Stomach | CAG with IM | ribosomal subunit export from nucleus | 4/1050 | 14/18723 | 6.26e-03 | 4.75e-02 | 4 |
GO:0033750 | Stomach | CAG with IM | ribosome localization | 4/1050 | 14/18723 | 6.26e-03 | 4.75e-02 | 4 |
GO:004603421 | Stomach | CSG | ATP metabolic process | 70/1034 | 277/18723 | 9.81e-28 | 2.60e-24 | 70 |
GO:000609121 | Stomach | CSG | generation of precursor metabolites and energy | 83/1034 | 490/18723 | 2.95e-20 | 3.12e-17 | 83 |
GO:004225521 | Stomach | CSG | ribosome assembly | 18/1034 | 61/18723 | 2.70e-09 | 3.07e-07 | 18 |
GO:000915021 | Stomach | CSG | purine ribonucleotide metabolic process | 46/1034 | 368/18723 | 1.89e-07 | 1.26e-05 | 46 |
GO:000616321 | Stomach | CSG | purine nucleotide metabolic process | 48/1034 | 396/18723 | 2.61e-07 | 1.66e-05 | 48 |
GO:000925921 | Stomach | CSG | ribonucleotide metabolic process | 46/1034 | 385/18723 | 6.97e-07 | 3.75e-05 | 46 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF6 | SNV | Missense_Mutation | | c.427G>T | p.Ala143Ser | p.A143S | P56537 | protein_coding | tolerated(0.05) | benign(0.192) | TCGA-CM-6163-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | novel | c.268N>T | p.Asp90Tyr | p.D90Y | P56537 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | novel | c.268N>T | p.Asp90Tyr | p.D90Y | P56537 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | | c.205N>A | p.Gly69Ser | p.G69S | P56537 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | | c.368G>T | p.Arg123Met | p.R123M | P56537 | protein_coding | deleterious(0.01) | benign(0.142) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | | c.200G>T | p.Arg67Met | p.R67M | P56537 | protein_coding | deleterious(0) | possibly_damaging(0.838) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | rs144752898 | c.430G>A | p.Asp144Asn | p.D144N | P56537 | protein_coding | tolerated(0.42) | benign(0.009) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | rs773641573 | c.254N>A | p.Arg85His | p.R85H | P56537 | protein_coding | deleterious(0.01) | possibly_damaging(0.9) | TCGA-BG-A0M9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | novel | c.313N>A | p.Gly105Ser | p.G105S | P56537 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF6 | SNV | Missense_Mutation | rs768741006 | c.511G>A | p.Asp171Asn | p.D171N | P56537 | protein_coding | tolerated(0.07) | benign(0.151) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |