Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/LASP1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/LASP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/LASP1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/LASP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/LASP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/LASP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/LASP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009030717 | Thyroid | PTC | mitotic spindle assembly | 33/5968 | 65/18723 | 1.17e-03 | 6.81e-03 | 33 |
GO:00107175 | Thyroid | PTC | regulation of epithelial to mesenchymal transition | 46/5968 | 99/18723 | 1.66e-03 | 9.13e-03 | 46 |
GO:009016218 | Thyroid | PTC | establishment of epithelial cell polarity | 18/5968 | 31/18723 | 2.31e-03 | 1.22e-02 | 18 |
GO:00309536 | Thyroid | PTC | astral microtubule organization | 8/5968 | 10/18723 | 2.46e-03 | 1.27e-02 | 8 |
GO:19012034 | Thyroid | PTC | positive regulation of extracellular matrix assembly | 8/5968 | 10/18723 | 2.46e-03 | 1.27e-02 | 8 |
GO:00101713 | Thyroid | PTC | body morphogenesis | 23/5968 | 43/18723 | 2.66e-03 | 1.35e-02 | 23 |
GO:00002804 | Thyroid | PTC | nuclear division | 167/5968 | 439/18723 | 3.27e-03 | 1.60e-02 | 167 |
GO:00905049 | Thyroid | PTC | epiboly | 19/5968 | 35/18723 | 4.94e-03 | 2.29e-02 | 19 |
GO:00850293 | Thyroid | PTC | extracellular matrix assembly | 23/5968 | 45/18723 | 5.62e-03 | 2.55e-02 | 23 |
GO:19018793 | Thyroid | PTC | regulation of protein depolymerization | 39/5968 | 87/18723 | 7.59e-03 | 3.24e-02 | 39 |
GO:00443199 | Thyroid | PTC | wound healing, spreading of cells | 18/5968 | 34/18723 | 8.65e-03 | 3.62e-02 | 18 |
GO:00905059 | Thyroid | PTC | epiboly involved in wound healing | 18/5968 | 34/18723 | 8.65e-03 | 3.62e-02 | 18 |
GO:19018804 | Thyroid | PTC | negative regulation of protein depolymerization | 33/5968 | 72/18723 | 9.04e-03 | 3.75e-02 | 33 |
GO:006048514 | Thyroid | PTC | mesenchyme development | 112/5968 | 291/18723 | 9.48e-03 | 3.90e-02 | 112 |
GO:00514978 | Thyroid | PTC | negative regulation of stress fiber assembly | 17/5968 | 32/18723 | 1.02e-02 | 4.11e-02 | 17 |
GO:00432447 | Thyroid | PTC | regulation of protein-containing complex disassembly | 51/5968 | 121/18723 | 1.09e-02 | 4.37e-02 | 51 |
GO:19012012 | Thyroid | PTC | regulation of extracellular matrix assembly | 10/5968 | 16/18723 | 1.13e-02 | 4.49e-02 | 10 |
GO:00070207 | Thyroid | PTC | microtubule nucleation | 18/5968 | 35/18723 | 1.26e-02 | 4.90e-02 | 18 |
GO:002241124 | Thyroid | ATC | cellular component disassembly | 248/6293 | 443/18723 | 1.34e-22 | 3.69e-20 | 248 |
GO:014001416 | Thyroid | ATC | mitotic nuclear division | 171/6293 | 287/18723 | 1.13e-19 | 1.66e-17 | 171 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LASP1 | SNV | Missense_Mutation | novel | c.108N>T | p.Lys36Asn | p.K36N | Q14847 | protein_coding | tolerated(0.05) | benign(0.033) | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LASP1 | SNV | Missense_Mutation | | c.650N>C | p.Asp217Ala | p.D217A | Q14847 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
LASP1 | SNV | Missense_Mutation | | c.326N>A | p.Arg109Lys | p.R109K | Q14847 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
LASP1 | insertion | In_Frame_Ins | novel | c.233_234insAATACTATTCCTATT | p.Ser78delinsArgIleLeuPheLeuPhe | p.S78delinsRILFLF | Q14847 | protein_coding | | | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
LASP1 | insertion | In_Frame_Ins | novel | c.235_236insCAGATA | p.Glu79delinsAlaAspLys | p.E79delinsADK | Q14847 | protein_coding | | | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
LASP1 | SNV | Missense_Mutation | | c.90C>G | p.Phe30Leu | p.F30L | Q14847 | protein_coding | deleterious(0) | benign(0.442) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LASP1 | SNV | Missense_Mutation | | c.164C>T | p.Ala55Val | p.A55V | Q14847 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LASP1 | SNV | Missense_Mutation | | c.164N>T | p.Ala55Val | p.A55V | Q14847 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LASP1 | SNV | Missense_Mutation | novel | c.64N>A | p.Asp22Asn | p.D22N | Q14847 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LASP1 | SNV | Missense_Mutation | | c.616N>T | p.Arg206Trp | p.R206W | Q14847 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |