![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF580 |
Gene summary for ZNF580 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF580 | Gene ID | 51157 |
Gene name | zinc finger protein 580 | |
Gene Alias | ZNF580 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | Q9UK33 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51157 | ZNF580 | LZE4T | Human | Esophagus | ESCC | 3.96e-10 | 3.77e-01 | 0.0811 |
51157 | ZNF580 | LZE5T | Human | Esophagus | ESCC | 3.43e-02 | 3.00e-01 | 0.0514 |
51157 | ZNF580 | LZE20T | Human | Esophagus | ESCC | 4.30e-04 | 2.63e-01 | 0.0662 |
51157 | ZNF580 | LZE24T | Human | Esophagus | ESCC | 7.90e-23 | 5.14e-01 | 0.0596 |
51157 | ZNF580 | P1T-E | Human | Esophagus | ESCC | 2.91e-15 | 8.09e-01 | 0.0875 |
51157 | ZNF580 | P2T-E | Human | Esophagus | ESCC | 5.29e-54 | 8.11e-01 | 0.1177 |
51157 | ZNF580 | P4T-E | Human | Esophagus | ESCC | 2.08e-21 | 6.92e-01 | 0.1323 |
51157 | ZNF580 | P5T-E | Human | Esophagus | ESCC | 1.34e-18 | 3.52e-01 | 0.1327 |
51157 | ZNF580 | P8T-E | Human | Esophagus | ESCC | 9.72e-98 | 1.70e+00 | 0.0889 |
51157 | ZNF580 | P9T-E | Human | Esophagus | ESCC | 3.00e-12 | 4.53e-01 | 0.1131 |
51157 | ZNF580 | P10T-E | Human | Esophagus | ESCC | 3.51e-88 | 1.24e+00 | 0.116 |
51157 | ZNF580 | P11T-E | Human | Esophagus | ESCC | 7.67e-16 | 9.95e-01 | 0.1426 |
51157 | ZNF580 | P12T-E | Human | Esophagus | ESCC | 6.17e-56 | 1.03e+00 | 0.1122 |
51157 | ZNF580 | P15T-E | Human | Esophagus | ESCC | 5.93e-50 | 1.28e+00 | 0.1149 |
51157 | ZNF580 | P16T-E | Human | Esophagus | ESCC | 7.11e-43 | 6.62e-01 | 0.1153 |
51157 | ZNF580 | P17T-E | Human | Esophagus | ESCC | 1.23e-13 | 7.45e-01 | 0.1278 |
51157 | ZNF580 | P19T-E | Human | Esophagus | ESCC | 9.24e-09 | 9.50e-01 | 0.1662 |
51157 | ZNF580 | P20T-E | Human | Esophagus | ESCC | 5.77e-22 | 5.05e-01 | 0.1124 |
51157 | ZNF580 | P21T-E | Human | Esophagus | ESCC | 3.36e-42 | 7.39e-01 | 0.1617 |
51157 | ZNF580 | P22T-E | Human | Esophagus | ESCC | 1.27e-83 | 1.34e+00 | 0.1236 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00703019 | Skin | cSCC | cellular response to hydrogen peroxide | 40/4864 | 98/18723 | 9.33e-04 | 6.38e-03 | 40 |
GO:001063125 | Skin | cSCC | epithelial cell migration | 115/4864 | 357/18723 | 4.64e-03 | 2.37e-02 | 115 |
GO:009013225 | Skin | cSCC | epithelium migration | 115/4864 | 360/18723 | 6.20e-03 | 3.04e-02 | 115 |
GO:009013025 | Skin | cSCC | tissue migration | 115/4864 | 365/18723 | 9.81e-03 | 4.33e-02 | 115 |
GO:000166727 | Skin | cSCC | ameboidal-type cell migration | 146/4864 | 475/18723 | 1.05e-02 | 4.58e-02 | 146 |
GO:0006979113 | Thyroid | PTC | response to oxidative stress | 234/5968 | 446/18723 | 6.97e-20 | 9.77e-18 | 234 |
GO:0062197113 | Thyroid | PTC | cellular response to chemical stress | 180/5968 | 337/18723 | 1.36e-16 | 1.16e-14 | 180 |
GO:0034599113 | Thyroid | PTC | cellular response to oxidative stress | 151/5968 | 288/18723 | 2.82e-13 | 1.43e-11 | 151 |
GO:0000302113 | Thyroid | PTC | response to reactive oxygen species | 121/5968 | 222/18723 | 2.10e-12 | 9.26e-11 | 121 |
GO:0042542113 | Thyroid | PTC | response to hydrogen peroxide | 86/5968 | 146/18723 | 1.39e-11 | 5.60e-10 | 86 |
GO:0034614112 | Thyroid | PTC | cellular response to reactive oxygen species | 82/5968 | 155/18723 | 4.32e-08 | 9.27e-07 | 82 |
GO:007030116 | Thyroid | PTC | cellular response to hydrogen peroxide | 54/5968 | 98/18723 | 1.62e-06 | 2.27e-05 | 54 |
GO:0001667112 | Thyroid | PTC | ameboidal-type cell migration | 198/5968 | 475/18723 | 3.36e-06 | 4.34e-05 | 198 |
GO:0010634111 | Thyroid | PTC | positive regulation of epithelial cell migration | 85/5968 | 176/18723 | 3.83e-06 | 4.80e-05 | 85 |
GO:0010631111 | Thyroid | PTC | epithelial cell migration | 149/5968 | 357/18723 | 4.83e-05 | 4.33e-04 | 149 |
GO:0090132111 | Thyroid | PTC | epithelium migration | 149/5968 | 360/18723 | 7.89e-05 | 6.74e-04 | 149 |
GO:0090130111 | Thyroid | PTC | tissue migration | 150/5968 | 365/18723 | 1.13e-04 | 9.01e-04 | 150 |
GO:0010632111 | Thyroid | PTC | regulation of epithelial cell migration | 123/5968 | 292/18723 | 1.33e-04 | 1.05e-03 | 123 |
GO:001059516 | Thyroid | PTC | positive regulation of endothelial cell migration | 61/5968 | 133/18723 | 4.95e-04 | 3.25e-03 | 61 |
GO:003210316 | Thyroid | PTC | positive regulation of response to external stimulus | 167/5968 | 427/18723 | 8.31e-04 | 5.13e-03 | 167 |
Page: 1 2 3 4 5 6 7 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF580 | CAF | Cervix | ADJ | SLC25A11,SERTM1,FOXO6, etc. | 1.77e-01 | ![]() |
ZNF580 | MVA | Liver | Healthy | HES4,MCAM,COL18A1, etc. | 5.80e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |